SOLUTION OF SOCIAL PROBLEMS IN
MANAGEMENT AND ECONOMY
International scientific-online conference
79
ALZHEIMER'S DISEASE AND THE RESEARCH METHODS OF
SCIENTISTS ON THIS DISEASE
Akbaraliyev Xojiakbar Shuhrat o‘g‘li
Alfraganus University Faculty of Medicine
2nd year student of the Pharmacy Department
Madatova Nazira Abdugaffarovna
Alfraganus University Faculty of Medicine
Associate Professor, Department of Pharmacy and Chemistry
https://doi.org/10.5281/zenodo.16267081
Abstract:
Alzheimer's disease is a disease that has been incurable for many
years. In this scientific article, we will compare the research methods of
scientists on Alzheimer's disease and examine how useful these research
methods are for patients.
Keywords:
DEMENTIA, Cognitive, neurology, chronological, MRI, episodic
memory, dementia, neurofibrillary, plaque.
Introduction:
During Alzheimer's disease, a number of pathological
processes occur in the div. For example, proteins are formed incorrectly in
brain tissue - the accumulation of amyloid beta and tau proteins. Plaques are
formed from small peptides. Senile plaques also appear. In addition, there is a
"loss" of neurons and synaptic connections. This leads to atrophy of certain
areas of the cerebral cortex. Simply put, there is a massive loss of nerve cells.
There is a lack of substances necessary for the transmission of nerve impulses.
The disease progresses gradually.
Every seven seconds, someone in the world is
diagnosed with Alzheimer's disease. Alzheimer's disease, which deprives a
person of mental abilities, especially memory, is threatening not only the elderly,
but also some young people in recent years. Alzheimer's disease is a disease
described by ancient doctors, but German psychiatrist Alois Alzheimer was
finally able to determine its causes, course and symptoms in 1901. Six years
later, he studied the course of the disease in detail in one of his patients. Since
then, the disease has been named after him. This disease usually occurs in
people over 65 years old. However, early-onset Alzheimer's disease also exists,
and this form of the disease is rare. It was ranked among the global diseases in
2006, with 26.6 million people suffering from the disease. There are also
suggestions that this number may increase fourfold by 2050.
Relevance of the scientific work:
Alzheimer's disease is one of the most
incurable diseases in the world. Earlier this year, scientists from the Hefei
Academy of Sciences in China introduced a new multi-tasking learning system
called DEMENTIA for early detection and progression assessment of Alzheimer's
SOLUTION OF SOCIAL PROBLEMS IN
MANAGEMENT AND ECONOMY
International scientific-online conference
80
disease. The researchers explained that Alzheimer's disease is becoming an
increasingly urgent problem as the population ages, and early diagnosis is key to
improving the condition of patients. One of the first signs of cognitive decline is
speech impairment. In recent months, scientists at Stanford University have
developed an innovative blood test that can assess the biological age of key
organs. "We have developed an age index for your organs based on blood. Using
this index, we can assess the age of an organ today and predict the likelihood of
developing a disease related to that organ in ten years," said Tony Wiss-Corey,
Ph.D., professor of neurology and neurological sciences.
Methods:
The scientific article notes that human organs can age at different
rates and times. The study, based on the study of protein profiles, allows you to
identify differences between the chronological and biological age of the kidneys,
muscles, heart, lungs and other organs. However, scientists have long
emphasized that the main indicator of life expectancy is brain age. Experts from
the American Center for Memory and Alzheimer's Disease followed 404 elderly
people for 7 years, wearing special "smart" watches to monitor physical activity.
In addition, the participants regularly underwent MRI scans of the brain and
passed memory and thinking tests. The participants spent an average of about
13 hours a day sitting or lying down. The results showed that those who
remained inactive for longer periods of time had impaired episodic memory,
decreased volume in certain parts of the brain, and also showed changes
characteristic of the early stages of Alzheimer's disease.
Results:
Turning to recent data, experts from the World Health
Organization (WHO) have identified the main risk factors for Alzheimer's
disease. There are several hypotheses about the causes of Alzheimer's disease,
the most common of which are forms of dementia. The disease is characterized
by the accumulation of amyloid plaques and neurofibrillary tangles in brain
tissue. However, it is still not clear what causes these changes. A person cannot
change hereditary conditions, but he can change his habits to prevent the
disease. WHO has named several factors that contribute to the development of
Alzheimer's disease. Analyzing many years of research on neurodegenerative
diseases, scientists have concluded that lack of physical activity, unhealthy diet
and excessive alcohol consumption increase the risk of diseases such as
Alzheimer's.
Cognitive impairment can also develop against the background of other
diseases and health conditions: diabetes, high blood pressure, high cholesterol
and obesity. Health experts also warn about the connection between Alzheimer's
SOLUTION OF SOCIAL PROBLEMS IN
MANAGEMENT AND ECONOMY
International scientific-online conference
81
disease and hearing loss and depression. In addition, social isolation and mental
inactivity can also trigger the development of the disease, the WHO noted.
Summary:
Alzheimer's disease, these research methods conducted by
scientists may not be a complete cure for the disease, but they can help patients
slow the progression of the disease. Although the disease is mainly prevalent in
the United States, scientists around the world are conducting research and
studies on this disease. We hope that Alzheimer's disease will not become one of
the diseases for which no cure has been found in the near future
Foydanilgan adabiyotlar ro’yxati:
1.
Clinical Psychiatry: A Textbook For Students And Physicians (Reprint).
Andoza:Нп3. ISBN 1-4325-0833-4.
2.
Alzheimer's Association. Recognized de mentia!care!training!programs.
Accessed February 2, 2024.
3.
https://daryo.uz/search?q=ALSGEYMER&type=news&date=2025-07-
09+05%3A40&utm=from_article_bottom_hashtags.
4.
World Health Organization (WHO). (2023). Dementia and Alzheimer’s
Disease Report.
