The conditions for low and highly substituted water-soluble carboxymethyl cellulose synthesis based on microcrystalline and powder cellulose by the suspension method have been investigated. Accordingly, it was obtained CMC water-soluble samples with 0.38-0.40 substitution degree based on microcrystalline and powder cellulose. And at one stage, there were obtained CMC samples with a high degree of substitution (1.4) by carboxymethylation so called polyanionic cellulose.