Distribution Of PPARG Gene Pro12Ala Polymorphism
Abstract
The present study reports for the first time the genotypic distribution of PPARG Pro12Ala polymorphism in group of Uzbek athletes. The human peroxisome proliferator-activated receptor gamma (PPARγ) is involved in lipid storage, glucose homeostasis and adipocyte differentiation. Pro-allele contributes to the development of high physical performance in sports where you need extra physical stamina, and Ala-allele - in sports based on the strength and speed. An analysis of the distribution frequency of genotypes of the PPARG gene, based on the general model of inheritance, in the group of athletes involved in football, was statistically significant compare to control (p =0.004). These results suggest that the presence of PPARG Ala allele, which increases the sensitivity of muscle tissue to insulin, and thus enhancing its anabolic effect on skeletal muscle, predisposes the development and display of speed-power qualities. In addition, we are studied frequencies of Pro/Ala genotypes in Uzbek population in comparison with Russian, Ukrainian, Italian, Bosnian and Herzegovinian, and Ethiopian samples. In conclusion, the present data seem to suggest that some selective factors such as climate could have influenced the present distribution of the Ala allele.
Similar Articles
-
The Analysis Of Influence Of Productions Of Open Mountain Works On Environment At Formation Of Various Zones On Deep Open-Cast Mines
The American Journal of Applied sciences: No. 12 (2020) / Nasirov Utkir Fatidinovich, Ochilov Shukhratulla Atoevich, Umirzoqov Azamat Abdurashidovich, -
Main Features Of The Geodynamic Evolution Of Domesozoic Formations And Metallogenic Zoning Of Endogenous Gold Mineralization Of The Tien-Shan Origenic Vein System
The American Journal of Applied sciences: No. 10 (2020) / Movlanov J.J. , S.M. Koloskova, -
Charge State Of Impurity Atoms In Semiconductors Studyed By The Emission Mössbauer Spectroscopy Method
The American Journal of Applied sciences: No. 5 (2021) / Ergash Yuldashevich Turaev, Jasurbek Jumaev , Shahlo Karimova, -
Application Of Mössbauer Spectroscopy To Determine The Parameters Of The EFG Tensor At Barium Nodes For УBA2CU3O7-X
The American Journal of Applied sciences: No. 5 (2021) / E.Yu. Turaev, S.Ya. Shaimardonova , Sh.S. Zamonova , A.O Khodzhamov, -
Methods For Generation Of Cluster Particles Of Different Stochiometry
The American Journal of Applied sciences: No. 12 (2020) / Khozhiev Sh.T., Kosimov I.O., Murodkobilov D.M., Gaibnazarov B.B. , Bekmirzaev.J.N. , -
Perspective Of Using Muruntau Career’s Overburden As Back Up Sources Of Raw Materials
The American Journal of Applied sciences: No. 01 (2021) / Naimova Rano Shukurovna , Norova Xurshida Yunusovna , Jurayev Salokhiddin Jumaboyevich , Umirzoqov Azamat Abdurashidovich , -
Stratigraphic Characteristic Devon System Of Mountain Kuldzhuktau (South Tian-Shan)
The American Journal of Applied sciences: No. 12 (2020) / Nodir Khairullaevich Davlatov,
References
Beunen G., Thomis M. //Gene driven power athletes? Genetic variation in muscular strength and power / BrJSportsMed. 2006. 40 (10): P.822-823.
Karpe F., Ehrenborg E.E. // PPARδ in humans: genetic and pharmacological evidence for a significant metabolic function / CurrOpinLipidol. 2009. 20(4): P.333-336.
Bray M.S., Hagberg J.M., Pérusse L., et al. // The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update / Med Sci Sports Exerc. 2009. 41(1): P.35-73.
Desvergne B., Wahli W. // Peroxisome proliferator activated receptors: nuclear control of metabolism / Endocr Rev. 1999. 20: P.649-688.
Michalik L., Auwerx J., Berger J.P., et al. // International union of pharmacology. LXI. Peroxisome proliferator activated receptors / Pharmacol Rev. 2006. 58: P.726-741.
Yessoufou A., Wahli W. // Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels / Swiss Med Wkly. 2010; w13071; P.140.
Nuclear Receptors Nomenclature Committee. A unified nomenclature system for the nuclear receptor superfamily. Cell. 1999. 97: P.1-3.
www.ncbi.nlm.nih.gov/gene
Eynon N., Meckel Y., Alves A.J., et al. // Is there an interaction between PPARD T294C and PPARG C1A Gly482Ser polymorphisms and human endurance performance? / ExpPhysiol. 2009a. 94 (11): P.1147-1152.
Meirhaeghe A., Amouyel P. // Impact of genetic variation of PPARG in humans / Mol Genet Metab. 2004. 83(1-2): P.93-102.
Fajas L., Auboeuf D., Raspe E., et al. // The organization, promoter analysis, and expression of the human PPARG gene / J Biol Chem. 1997. 272: P.18779-18789.
Yen C.J., Beamer B.A., Negri C., et al. // Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARG) gene in diabetic Caucasians: identification of a Pro12Ala PPARG2 missense mutation / BiochemBiophys Res Commun. 1997. 241: P.270-274.
Deeb S.S., Fajas L., Nemoto M., Pihlajamäki J., Mykkänen L., et al. // A Pro12Ala substitution in PPARG2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity / Nat Genet. 1998. 20: P.284-287.
Masugi J., Tamori Y., Mori H., Koike T., Kasuga M. // Inhibitory effect of a Proline-to-Alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ 2 on thiazolidinedione-induced adipogenesis / BiochemBiophys Res Commun. 2000. 268(1): P.178-182.
Yamamoto Y., Hirose H., Miyashita K., Nishikai K., Saito I., et al. // PPARG2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population / Metabolism. 2002. 51: P.1407-1409.
Schneider J., Kreuzer J., Hamann A., Nawroth P.P., Dugi K.A. // The Proline 12 Alanine substitution in the peroxisome Proliferator-activated receptor-γ2 gene is associated with lower lipoprotein lipase activity in vivo / Diabetes. 2002. 51: P.867-870.
Simon I., Vendrell J., Gutierrez C., Fernández-Real J.M., Vendrell I., et al. // Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ is associated with increased leptin levels in women with type-2 diabetes mellitus / Horm Res. 2002. 58: P.143-149.
Ek J., Andersen G., Urhammer S.A., Hansen L., Carstensen B., et al. // Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-G2) gene in relation to insulin sensitivity among glucose tolerant Caucasians / Diabetologia. 2001. 44(9): P.1170-1176.
Koch M., Rett K., Maerker E., et al. // The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects / Diabetologia. 1999. 42: P.758-762.
Stumvoll M., Wahl H.G., Löblein K., et al. // The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with increased antilipolytic insulin sensitivity / Diabetes. 2001. 50: P.876-881.
Vänttinen M., Nuutila P., Pihlajamäki J., et al. // The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-γ2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study / ClinEndocrinolMetab. 2005. 90(7): P.4249-4254.
Thamer C., Haap M., Volk A., et al. // Evidence for greater oxidative substrate flexibility in male carriers of the Pro12Ala polymorphism in PPARG2. HormMetab Res. 2002. 34: P.132-136.
Beamer B.A., Yen C.J., Andersen R.E., et al. // Association of the Pro12Ala variant in the peroxisome proliferator activated receptor-γ2 gene with obesity in two Caucasian populations / Diabetes. 1998. 47: P.1806-1808.
Doney A., Fischer B., Frew D., et al. // Haplotype analysis of the PPARG Pro12Ala and C1431T variants reveals opposing associations with body weight / BMC Genet. 2002. 3: P.21.
Ek J., Urhammer S.A., Sørensen T.I., et al. // Homozygosity of the Pro12Ala variant of the peroxisome proliferation activated receptor-γ2 (PPAR-γ2): divergent modulating effects on body mass index in obese and lean Caucasian men / Diabetologia. 1999. 42(7): P.892-895.
Franks P.W., Luan J., Browne P.O., et al. // Does peroxisome proliferator-activated receptor γ genotype (Pro12Ala) modify the association of physical activity and dietary fat with fasting insulin level? / Metabolism. 2004. 53 (1): P.11-16.
Kawaguchi H., Akune T., Yamaguchi M., et al. // Distinct effects of PPARγ insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells / J Bone Miner Metab. 2005. 23: P.275-279.
Cock T.A., Back J., Elefteriou F., et al. // Enhanced bone formation in lipodystrophic PPARG (hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO Rep. 2004. 5: P.1007-1012.
Ahmetov I.I., Mozhayskaya I.A., Lyubaeva E.V., et al. // PPARG gene polymorphism and locomotor activity in humans / Bull ExpBiol Med. 2008. 146 (5): P.630-632.
Akhmetov I.I., Popov D.V., Mozhayskaya I.A., et al. // Association of regulatory genes polymorphisms with aerobic and anaerobic performance of athletes / Ross FiziolZhIm. 2007. 93 (8): P.837-843.
Ahmetov I.I., Mozhayskaya I.A., Lyubaeva E.V., Vinogradova O.L., Rogozkin V.A. // Association of polymorphism PPARG with a predisposition to the development of power-speed / Biomedical technologies improve efficiency in the conditions of intense physical exertion. – 2007. 3, P.22-28.
Miller S.A., Dykes D.D., Polesky H.F. // A simple salting out procedure for extracting DNA from human nucleated cells / Nucleic Acids Res 1988. 16: P.1215.
Bondar I.A., Filipenko M.L., Shabelnikova О.Yu., Sokolova Е.А.. // Association of polymorphism PPARG pro12ala rs1801282 marker with diabetes type 2 in Novosibirsk region and other population / Siberian medical journal, 2014. 29 (2), P.75-78.
Zyablitsev S.V., Mokriy V.Ya. Association of polymorphism 12Pro with diabetes type 2 / Clinical endocrinology and endocrine surgery. 2016. 3 (55), P.33-37.
Dujic T., Bego T., Mlinar B., Semiz S., Malenica V., Prnjavorac B., Ostanek B., Marc J., Causević A. // Effects of the PPARG gene polymorphisms on markers of obesity and the metabolic syndrome in bosnian subjects / Journal of Medical Biochemistry. 2014. 33(4), P.323-332.
Scacchi R., Pinto A., Rickards O., Pacella A., De Stefano G.F., Cannella C., Corbo R.M.. // An analysis of peroxisome proliferator-activated receptor gamma (PPAR-G2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits. Nutrition / Metabolism & Cardiovascular Diseases. 2007. 17, P.632-641.
