Hyperhomocysteinemia And Pathogenetic Mechanisms Of Ischemic Stroke
Keywords:
Abstract
The article is intended to give basic information and the role of homocysteine in the human body. The amino acid homocysteine is a product of methionine demethylation. When the level of homocysteine increases, it damages the tissue structures of the arteries, initiating the release of cytokines, cyclins and other inflammatory mediators. Its accumulation leads to loosening of the arterial walls, the formation of local defects in the endothelium, which, in turn, leads to the deposition of cholesterol and calcium on the vascular wall. Hyperhomocysteinemia as a consequence of impaired homocysteine metabolism is considered an independent risk factor for stroke in humans. The role of neuroprotective therapy in interrupting or slowing down the sequence of damaging biochemical and molecular processes that can cause irreversible ischemic brain damage is shown.
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References
Asadullaev, M. M., Saidvaliev, F. S., Shermukhamedova, F. K., ZhK, R., & Vakhabova, N. M. (2012). Assessment of multimodal effect of cytoflavin in the acute brain stroke in patients with metabolic syndrome. Zhurnal nevrologii i psikhiatrii imeni SS Korsakova, 112(10), 24-27.
Makhmudovich, A. M., Sattarovna, R. G., Maksudovna, V. N., & Maksudovich, A. K. (2020). The Application Of Preparation Mavix In The Complex Treatment Of Ischemic Stroke In The Elderly Age. The American Journal of Medical Sciences and Pharmaceutical Research, 2(12), 55-63.
Ergasheva, M., & Vakhabova, N. (2019). New gender-influenced stroke study: Cognitive manifestations in acute ischemic stroke in Uzbekistan. Journal of the Neurological Sciences, 405, 115.
Ergasheva, M., Vakhabova, N., & Rakhimbaeva, G. (2019). Gender, aging and background diseases influence on the new neuronosological structure of acute ischemic stroke in Uzbekistan. Journal of the Neurological Sciences, 405, 115.
Zhukova, L. G., Abramov, M. E., Vakhabova, Y. V., Lud, A. N., Obukhov, A. A., & Lichinitser, M. R. (2009). Klinicheskaya effektivnost'i bezopasnost'primeneniya otechestvennogo rekombinantnogo granulotsitarnogo koloniestimuliruyushchego faktora Neypomaks® u bol'nykh rakom molochnoy zhelezy, poluchayushchikh khimioterapiyu doksorubitsinom i dotsetakselom. Journal of Modern Oncology, 11(3), 50-54.
Akramova, D., Rakhimbaeva, G., Vakhabova, N., & Narzikulova, M. (2017, January). The frequency of ischemic stroke depending on the season and it's gender features. In CEREBROVASCULAR DISEASES (Vol. 43). ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND: KARGER.
Вахабова, Н. М., Азизова, Р. Б., & Абдуллаева, Н. Н. (2019). Гендерные особенности факторов риска и фоновых заболеваний при разных вариантах ишемического инсульта у лиц пожилого и старческого возраста.
Асадуллаев, М. М., Саидвалиев, Ф. С., Шермухамедова, Ф. К., Ризвонов, Ж. К., & Вахабова, Н. М. (2012). Оценка мультимодального действия цитофлавина при остром мозговом инсульте, развившемся на фоне метаболического синдрома. Журнал неврологии и
Maksud, Asadullaev, et al. "Risk Factors and Background Diseases in Different Variants of Ischemic Stroke in the Elderly and Senile Age." International Journal on Orange Technologies, vol. 2, no. 10, 20 Oct. 2020, pp. 86-88, doi:10.31149/ijot.v2i10.733.
Umarov, A., Prokhorova, A., Rakhimbaeva, G., & Vakhabova, N. (2016, January). Stroke indidence and association with risk factors in women in Uzbekistan. In CEREBROVASCULAR DISEASES (Vol. 41, pp. 212-212). ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND: KARGER.
Umarov, A., Vakhabova, N., Prokhorova, A., & Narzikulova, M. (2016). PS-82 GENDER FEATURES OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) IN PATIENTS WITH ARTERIAL HYPERTENSION IN UZBEKISTAN. Journal of Hypertension, 34, e497.
Maksudovna, V. N. (2016). Indirect influence of hormonal status on the development of ischemic insult and its gender peculiarities. European science review, (9-10).
Umarov, A., & Vakhabova, N. (2017, January). Hormonal status in patients with ischemic stroke in uzbekistan-cortisol, estradiol and testosteron. In CEREBROVASCULAR DISEASES (Vol. 43). ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND: KARGER.
Tolibova, N., & Vakhabova, N. (2017). Gender differences in stroke subtypes, severity, risk factors, and outcomes among elderly patients with acute ischemic stroke in Uzbekistan. Journal of the Neurological Sciences, 381, 377.
One Patrushev L.I. Genetic mechanisms of hereditary disorders of hemostasis // Biochemistry.-2002.-T.67, No. 1.-P.40-55
Kilmer C. McCully, Chemical Pathology of Homocysteine, Intravenous Excitotoxicity, Oxidative Stress, Endothelial Dysfunction, and Inflammation, Climer C. McCully, Ann Clin. Laboratory Sci.-2009.-Vol.39, No. 3.-С 219-232
Wang H., Qin H., Demirtas H., LiJ, Mao G., Sun N., Liu L., Xu H. Effectiveness of folic acid in stroke prevention: a meta-analysis // Lancet.-2007-369.-1876 -1882.
Albert S, Cook R., Danielson E., Manson E. The effect of folic acid and vitamins at risk of ofcardiovascular events and overall mortality among women at high risk for cardiovascular disease: a randomized trial // JAMA.-2008.-299.-2027- 2036.
Zozulya I.S. Hyperhomocysteinemia and other metabolic predictors of the development and course of ischemic and stroke / Zozulya I.S., Shevchuk V.I., Bessmetnaya V.M .: P.L. Shupik National Medical Academy of Postgraduate Education, 2011.-P.34- 36.124-125.
Champe P., Harvey R. Biochemistry. Lippincott's Illustrated Reviews 4th ed. Philadelphia: Lippincott Williams and Wilkins, 2008: 261-276.
McCully KS. Chemical Pathology of Homocysteine. IV. Excitotoxicity, Oxidative Stress, Endothelial Dysfunction, and Inflammation. Ann Clin. Lab. Sci , 2009, 39 (3): 219-232.
Dietrich-Muszalska A., Malinowska J., Olas B et al. The oxidative stress may be induced by the ele- vated homocysteine in schizophrenic patients. Neurochem. Res., 2012, 37 (5): 1057-62.
Moll S., Varga EA Homocysteine and MTHFR Mutations. Circulation, 2015, 132: e6-9.
Elanchezhian R., Palsamy P., Madson CJ, Lynch DW, Shinohara T. Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and sup-pression of Nrf2-dependent antioxidant protec- tion. Chem Biol Interact 2012,200: 1-10.
Zhang D., Fang P., Jiang X., Nelson J., Moore JK, Kruger WD, Berretta RM, Houser SR, Yang X., Wang H. Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differ- entiation and atherosclerosis in LDLr / CBS-deficient mice. Circ Res, 2012, 111: 37-49.
Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J: Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol 2012,52: 753-760.
Zhong C, Xu T, Xu T, Peng Y, Wang A, Wang J, Peng H, Li Q, Geng D, Zhang D, Zhang Y, Zhang Y, Gao X, He J, Groups CI. Plasma Homocysteine and Prognosis of Acute Ischemic Stroke: a Gender- Specific Analysis From CATIS Rando mized Clinical Trial. Mol Neurobiol, DOI: 10.1007 / s12035-016-9799-0.
Han L, Wu Q, Wang C, Hao Y, Zhao J, Zhang L, Fan R, Liu Y, Li R, Chen Z, Zhang T, Chen S, Ma J, Liu S, Peng X, Duan S. Homocysteine, Ischemic Stroke,
and Coronary Heart Disease in Hyper tensive Patients: A Population-Based, Prospective Cohort Study. Stroke 2015, 46: 1777-1786.
Zhou BS, Bu GY, Li M, Chang BG, Zhou YP: Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population. Int J Mol Sci, 2014,15: 8931-8940.
Qin X, Li Y, Yuan H et al. Relationship of MTHFR gene 677C -> T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes. Medicine (Baltimore) 2015, 94: e563.
Yildiz SH, Ozdemir Erdogan M, Solak M et al. Lack of association between the methylenetetrahydropholate reductase gene A1298C poly- morphism and neural tube defects in a Turkish study group. Genet Mol Res, 2016, 15.
Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet 2005, 365: 224-232.
