Vol. 3 No. 02 (2021)

Premature menopause is a pathological condition characterized by the cessation of the functional activity of the ovaries in women under the age of 40 and manifested by amenorrhea, high levels of gonadotropins in the blood, infertility and symptoms of estrogen deficiency. POF occurs on average in 1% of women. The exact nature of the disease remains unknown. The basis of this pathology, regardless of the etiological factor, is a decrease in the reserve of primordial follicles, which is unusual for this age period, up to its complete depletion and the formation of the afollicular type of POF. This condition is described as a "multifactorial syndrome" due to chromosomal abnormalities, genetic disorders, fermentopathies, infectious and iatrogenic factors.

The Aim of this work was to study the functional activity of monocytes, neutrophils and cytokines in twin children with Inflammatory diseases of the paranasal sinuses in comparison with non-twins.  It was found that with various rhinosinusitis in children, phagocytic activity of monocytes in blood decrease, which causes the development of a chronic purulent focus and is characterized by an increase in monocytes with viral inclusions. In patients with Inflammatory diseases of the paranasal sinuses, the activity of non-specific protective factors of the body is significantly reduced, which is expressed in a decrease   phagocytic activity of monocytes   and an increase monocyte with viral inclusions, which is more evidently in twin children than in non-twin children. Serum cytokines in children with Inflammatory diseases of the paranasal sinuses were significantly increased in relation to the data of healthy children. In children-twins and non - twins, the parameters of anti-inflammatory cytokines changed in different directions.

Irritable bowel syndrome (IBS) is a biopsychosocial disorder that consists of a set of functional disorders that cannot be explained by organic changes in the intestines. At present, it is very important to determine the indicators of quality of life (QOL) in patients with various diseases. QOL analysis allows us to determine how well a patient is coping with the disease, and is also important for addressing many of the issues that arise during treatment. The main complaints of patients were fecal incontinence (100%) and pain syndrome (100%). In patients with IBS with predominance of diarrhea and constipation, the leading symptom in the clinical picture of the disease is pain throughout the bowel, which decreases or disappears after defecation, accompanied by flatulence and a feeling of complete bowel emptying. ± 0.25 points (according to the results of the GSRS survey), which corresponds to severe and moderate intensity pain syndrome. At the end of the course of treatment, a statistically significant decrease in the intensity of abdominal pain was observed in patients.

Connective tissue dysplasias (CTDs) are genetically determined conditions characterised by defects in fibrous structures and connective tissue basic substance, leading to organ and system malformations, having a progressive course, defining features of associated pathology, as well as pharmacokinetics and pharmacodynamics of drugs.

Using unified and developed methods, some hematological, biochemical, and micro-and macronutrient status indicators were studied in women of fertile age with a normal health index and iron deficiency. It is shown that there are certain pathological fluctuations in some hematological, biochemical and essential hematopoietic microelements in women of fertile age with the development of iron deficiency. In particular, there is a hypoproteinemia, hypoferremia, hypozincemia, hypocupremia and hypertransaminasemia.

In an experimental study, the morphofunctional features of the spleen of 6-month-old white rats were studied in normal conditions and in chronic radiation sickness.  The study found that in response to the action of a chronic radiation factor in the spleen of white rats, there is a decrease in structural parameters.  This is reflected in the morphological parameters of the organ.  As a result, the functional activity of the spleen’s lymphoid tissue decreases.

The article also examines the consequences of family relations, the health and age of the mother, the course of pregnancy, premorbid background in the form of childhood rickets, anemia, the state of the immune status in acute pneumonia, bronchiolitis, obstructive bronchitis in children.

Sociopathic families and children with dangerous factors are more likely to suffer from acute respiratory infections, fever, shortness of breath, prolonged coughing and pathological changes in the lungs. Compared to 2014, the incidence of pneumonia decreased by 22.7%, and the number of children with obstructive syndrome increased from 33.4% to 47.5%.

Using multivariate analysis to identify predictive risk parameters in the diagnosis of asymptomatic osteogenic metastasis of renal and prostate cancer. The work was based on the results of observations of 105 patients with a morphologically confirmed diagnosis of malignant neoplasm registered at the Republican Specialized Scientific and Practical Center of Oncology and Radiology (RSNPMTSO and R) and the Samarkand branch. In 62 patients with kidney cancer (RP) included in the study, the mean age of patients with RP was 58.3 years. 43 patients with prostate cancer (PC) were included in the study, the average age of patients with PC was 68 years. We analyzed such parameters as age, stage of the disease, timing of detection of bone metastasis (BM), prevalence, type and size of BM, as well as additional criteria: in case of prostate cancer - the size of the primary tumor and the degree of malignancy, in case of prostate cancer - the sum of points on the Gleason scale and the prostate -specific antigen (PSA). It was revealed that the highest risk in detecting BM in RP was noted for the stage of the disease, p = 0.006. Also, a high risk was associated with the size and grade of tumor malignancy, with CR at p = 0.006 and p = 0.008, respectively. Among the listed, the highest risk in detecting BM is observed in prostate cancer for the stage of the disease (p = 0.001). In addition, an increased risk was observed for the Gleason score and PSA level (p = 0.013 and p = 0.008, respectively). Thus, during the 2-year follow-up, BM most often develops in patients with kidney cancer at stage Tv-T3a stage and with grade G III and in patients with prostate cancer - in the presence of stage III with a Gleason score of ≥ 7 and a level PSA in the range of 21-50 ng / ml.

This article is devoted to the study of factors influencing quality indicators in experimental research (identification - analytical) and in determining the quality of the finished product. Dedicated to the research on the selection of the composition of "Ambronate" syrup, it contains the results of research on the selection of excipients and technology, as well as the quality of the finished syrup.

The article provides information about the botanical classification, composition, medicinal properties and collection procedures of the medicinal plant - the- Big Plantago

The methodological recommendation presents a comparative characteristic of surgical methods of treatment of deviation of the nasal septum. Deviation of the nasal septum occurs in the cartilaginous and bone regions, both separately and in both simultaneously. Deformations can be of different nature (bend, crest, spike) and localization. They are one and two-sided. Spines and ridges are more often localized at the junction of the quadrangular cartilage and the perpendicular plate, ploughshare, and the crest of the upper jaw (“growth zone”). Less often, the upper sections of the perpendicular plate and the rear section of the ploughshare are deformed. For traumatic deformities, characteristic bends with acute angles. Often, after injury, there is a displacement of the anterior edge of the quadrangular cartilage in the form of its subluxation. The deformation of the cartilaginous part of the external nose in patients under our supervision was caused by the deviation of the nasal septum. There were no patients with deformity of the nose who would have been indicated for surgical intervention on the cartilage of the external nose. When correcting the deformity of the external nose in patients, we used an exclusively closed technique of intervention with a transseptal access, and, if necessary, access under the upper lip, which allowed us to obtain a good cosmetic effect and minimize traumatic complications after surgery.

The article covers the etiology, pathogenesis, classification, diagnosis, clinical picture and treatment of coronary heart disease, provides a literature review. Cardiovascular disease (CVD) represents the leading cause of death among women as well as men. The number of deaths due to CVD in women are greater than in men. There are significant gender-related differences concerning CVD.

The research paper presents the results of diagnosis and treatment of 82 patients with focal thyroid masses. Based on a complex study of patients, main specific diagnostic criteria were determined, the use of which allows to detect thyroid cancer in their early stages. It was educed, that multiself-reactance ultrasonic research, including В-mode, EDC, DDC, spectral Doppler and elastography assist upgrading of research in the early exposure of chasse of thyroid.

This article reveals the need for study of the market of drugs used in hepatosis, it is rather difficult to substantiate and systematize the treatment of fatty hepatosis with such a variety of causes that cause it. therapy should be aimed at eliminating the causes, at stopping the syndromes of impaired digestion and absorption, at restoring the function of the liver and biliary system. this excludes the intake of certain drugs and alcohol abuse.

Psoriasis is a chronic non-infectious disease of a multifactorial nature, which often occurs in the form of rashes and peeling of the skin. Psoriasis occupies a significant share in the dermatological structure of diseases at the present time. [1, 2]. Despite the numerous scientific studies conducted by scientists in many countries regarding the etiology, pathogenesis, clinic and treatment of psoriasis, there is still a question about the main cause of the disease.In a significant number of patients with psoriasis, lesions of the nervous system, cardiovascular, gastrointestinal pathology, pathology of the genitourinary system, as well as, often with damage to the articular systems of the skeleton together with disorders of the immune system, were revealed. All this indicates the multifactorial nature of the disease. In this regard, the search for optimal drugs that would affect several pathogenetic links of the disease is currently underway. [3, 4,]. Therefore, today, we consider this issue relevant.

Urticaria is an allergic disease characterized by the appearance of blisters on the skin and mucous membranes. The disease can be caused by external factors (temperature, mechanical, chemical) or internal (diseases of internal organs, disorders of the nervous system). [1, 2]. Allergies can be caused by toxins, bacteria, and undigested food. In the diagnosis of the disease, anamnestic data, dermography and various skin allergological tests are used. There are acute (up to 6 weeks) and chronic (more than 6 weeks) urticaria. The latter is characterized by daily or frequent symptoms (blistering, itching, angioedema for 6 weeks or more [3, 4]. During life, 0.5-1% of the entire population of people suffers from chronic urticaria. At the same time, if acute urticaria is usually associated with the action of exogenous factors and allergens (food, medicines, insect bites, etc).

The article describes the results of research on the cultivation of Ferula assa-foetida L. plant, one of the valuable medicinal plant species. It was found that the seeds of Ferula assa-foetida L. plant have good germination properties in laboratory and field conditions, and it is possible to establish its industrial plantations by sowing the seeds.

The article is intended to give basic information and the role of homocysteine in the human body. The amino acid homocysteine is a product of methionine demethylation. When the level of homocysteine increases, it damages the tissue structures of the arteries, initiating the release of cytokines, cyclins and other inflammatory mediators. Its accumulation leads to loosening of the arterial walls, the formation of local defects in the endothelium, which, in turn, leads to the deposition of cholesterol and calcium on the vascular wall. Hyperhomocysteinemia as a consequence of impaired homocysteine metabolism is considered an independent risk factor for stroke in humans. The role of neuroprotective therapy in interrupting or slowing down the sequence of damaging biochemical and molecular processes that can cause irreversible ischemic brain damage is shown.

This article is scientifically and pedagogically based on the ways to increase the physical activity of 18-20 year old girls based on the development of a comprehensive program of fitness aerobics.

This article is devoted to giving a complete overview of the various diseases that the human body in life experiences through the respiratory tract.

Caries is a process of destruction of hard tooth tissues, which occurs with the participation of cariogenic bacteria in the oral cavity (in the composition of dental plaque), as well as food residues processed by them. The organic acids produced by the bacteria gradually destroy first the enamel of the tooth and then the underlying dentin. As a result, a carious cavity is formed in the tooth, the walls of which are filled with soft decay of decaying dental tissues and a large number of cariogenic bacteria. The following article looks into the reasons leading to dental problems, its diagnostics and treatment methods.

The management of midrace trauma continues to challenge maxillofacial surgeons. The complex local anatomy and functional and cosmetic importance of the region make precise surgical correction and reconstruction essential to success. The following article aims at looking for ways for treatment of the surgery.

Oral medicine is a specialty of dentistry related to the oral health care of patients with chronic, recurrent and drug-related diseases of the oral and maxillofacial area, as well as their diagnosis and non-surgical management.  The following article looks into the specific types of oral surgery and the procedures.

Dental implantation is a procedure of implanting an implant in the jawbone of the patient with subsequent prosthetics of their crowns, bridge or conditionally removable dentures. The implant is a pre-trained artificial construct that is embedded in the tissue of the jaw for future restorations. Implants are designed to replace the roots of lost teeth, allowing in the future restoring the dentition. The following article explores the process of implantation.