Toxicity And Anti-Arrhythmic Activity 1- (4-Dimethylaminophenyl Dimethylaminophenyl) -6, 7-Dimethoxy-1, 2, 3, 4 Tetrahydroisoquinoline
Keywords:
Abstract
The effect of 1 - (- 4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4-
tetrahydroisoquinoloin hydrochloride (conditionally –F-24) on antiarrhythmicactivity in
simulating calcium chloride arrhythmia, as well as acute toxicity in experiments, was
studied on white out bred rats with the intravenous route of administration. It was found
that the drug F-24 has a pronounced ant arrhythmic effect. The average effective (ED50)
ant arrhythmic dose is 4.8 mg/kg, the ant arrhythmic index is 20.3, which is significantly
more than the comparison drugs verapamil and lidocaine.
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References
S.V. Avetisyan, E.M. Markaryan, J.S. Arustamyan, R.E.Narkaryan, Chemical
and Pharmaceutical Journal of 2006, No. 7, pp. 16-17.
M. L. Belenky, “Elements of a quantitative assessment of the pharmacological
effect”, L-1963.
R. D. Kurbanov, “Guidelines for Clinical Cardiology. Tashkent 2007
R.U. Khabriev, “Guide to the experimental (preclinical) study of new
pharmacological substances, M.2005, p. 421-434.
M.D. Mashkovsky"Medicines" Moscow 2002y t 1.
E.M. Markaryan, J.S. Arustamyan, Avetisyan et al. Chemical-Pharmaceutical
Journal, 2000, No. 12, pp. 5-7.
A.G. Mikhailovsky, O. V. Goshnova, I. P. Rudinova, D. A. Peretyagin Chemical
and Pharmaceutical Journal of 2017, No. 7, pp. 25-27.
Sh.N. Jurakulov, V.I. Vinogradova, I.Z. Jumaev, P. B. Usmanov, Reports of the
Academy of Sciences of the Republic of Uzbekistan 2014, No. 3, pp. 51-54
