Vol. 2 No. 07 (2020)

Vol. 2 No. 07 (2020)
Published: 01-07-2020

Articles

24-30 80 32

Management Of A Patient With A Rare Variant Of Autoimmune Polyglandular Syndrome Of The Second Type

Negmatova Gulzoda Shuhratovna

The article considers a clinical case of a young patient with autoimmune polyglandular
syndrome type 2, represented by type 1 diabetes mellitus, thyroid dysfunction and
primary adrenal cortex insufficiency.

24-30 136 16

Management Of A Patient With A Rare Variant Of Autoimmune Polyglandular Syndrome Of The Second Type

Negmatova Gulzoda Shuhratovna

The article considers a clinical case of a young patient with autoimmune polyglandular
syndrome type 2, represented by type 1 diabetes mellitus, thyroid dysfunction and
primary adrenal cortex insufficiency.

123-129 88 30

Clinical Echocolpocsopy Features Of Cervical Cancer

Dilnoza Isakova,, Zebiniso Inakova,, Ranokhon Solieva,, Matkarimov Bakhtiyorjon, , Yorkinoy Farmankulova, Dilfuzahon Mamarasulova

In recent years, doctors of ultrasonic diagnostics and cancers began to pay attention to
the possibility to obtain information about the status of the cervix, especially with the aim
of assessing the prevalence of tumor process, which is especially important in planning
treatment. However, the information to date is fragmented and based on a small number
of publications. However, to date not clearly developed sonographic criteria for cervical
cancer, given the clinical course of the disease and possibilities of modern digital (digital)
ultrasonic equipment, transvaginally, color echocardiography to better identify cervical
pathology, which will improve timely, differential, and clarifying the diagnosis of cervical
cancer.

112-116 119 24

Molecular Genetic Factors Of Breast Cancer Development (Review)

Abdulla Nusratillayevich Abdukhakimov, Muqaddas Tukhtabievna Tukhtaboeva

The problem of timely detection of breast cancer is not only in its asymptomatic
development, but also in the absence of reliable diagnostic markers that contribute to the
early detection of the neoplastic process. The main objectives of oncogenomics are to
study the molecular mechanisms of carcinogenesis and develop optimal methods for
preventing, diagnosing and monitoring cancer. One approach to solving this problem is to
analyze the epigenetic characteristics of the tumor genome.

12-17 81 25

Nominal Capital, Sexual Orientation And Instructive Level – Effect On Self-Appraised Wellbeing

Lars Janlert, Lyan Emmelin

Nominal capital has been perceived as one significant nominal determinant for wellbeing,
however we despite everything have constrained information about how it tends to be
utilized to clarify imbalance in wellbeing. This examination researched the connections
between singular nominal capital and self-evaluated wellbeing by sexual orientation and
instructive level, and investigated if access to nominal capital may clarify the watched
inconsistencies in self-appraised wellbeing among people and distinctive instructive
gatherings. Study structure: Strategies:

94-104 64 35

Step-By-Step Rehabilitation Of Children With Congenital Clearance Of The Upper Lip And Palate

Mirxayidov Miraziz Mirxoliq O’g’li

This article gives information on Step-by-step rehabilitation of children with congenital
clearance of the upper lip and palate. A review of the reported data on the frequency of
birth, prevalence, territorial peculiarities, clinical manifestations, organization of medical
aid to children with congenital cleft lip and palate, staged rehabilitation is presented in the
paper.

18-23 95 34

Indian Thermal Atmosphere And Surgery Result In Older Sufferer

Abhishek Nigam , Anurag Panday

While inspecting our medical clinic mortality record, we discovered higher careful mortality in
the long periods of summer season which enlivened us to investigate the effect of blistering
atmosphere in old careful sufferer. Meteorological elements, quiet attributes, careful hazard
factors and other related information were noted. Information was dissected utilizing
student's't' and z-test for factual noteworthiness. Results: There were factually critical
entanglements and delayed emergency clinic remain in bunch II when contrasted with I
(13.21±6.44 Versus 9.81±3.54 days, P esteem =0.01) on univariate examination. High
hazard sufferer had more complexities in blistering climate. Stepwise multivariate relapse
investigation indicated higher unfavorable effect of poor physical and cardiovascular status
than hot atmosphere.

1-6 56 28

Circulating Tumor Cells: Atomic Properties And Hostile To Malignant Growth Treatment Checking

Kakharman Nogaibayeva, Gulbarshin Sultanova

Presence of Сirculating tumor cells (CTCs) in blood of disease patients, affirms about a
scattering of malignant growth cells to the fringe circulatory system, on the most punctual
phases of malignancy improvement and all the time vouches for an unfavorable clinical ebb
and flow, particularly it is associated with arrangement of metastases. Moreover, these
phones can speak to the base lingering infection and quantitative observing of CTCs level in
time of hostile to malignant growth treatment furnishes specialiCDC with important data. For
now the job of epithelial-to-mesenchymal travel (EMT) and mesenchymal-to-epithelial travel
(MET) in arrangement of different subpopulations CTCs, in development of malignancy
forceful properties. In this article we need to demonstrate the reason and issues of our
logical exploration - the cytological atomic investigation of flowing tumor cells have
separated by the size ward ISET innovation.

130-133 70 36

Toxicity And Anti-Arrhythmic Activity 1- (4-Dimethylaminophenyl Dimethylaminophenyl) -6, 7-Dimethoxy-1, 2, 3, 4 Tetrahydroisoquinoline

RejepovJumadilla,, Rakhmanova Hilola, Azamatov Aziz

The effect of 1 - (- 4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4-
tetrahydroisoquinoloin hydrochloride (conditionally –F-24) on antiarrhythmicactivity in
simulating calcium chloride arrhythmia, as well as acute toxicity in experiments, was
studied on white out bred rats with the intravenous route of administration. It was found
that the drug F-24 has a pronounced ant arrhythmic effect. The average effective (ED50)
ant arrhythmic dose is 4.8 mg/kg, the ant arrhythmic index is 20.3, which is significantly
more than the comparison drugs verapamil and lidocaine.

117-122 124 36

Correction Of Cognitive Disorder In Patients With HIV - Associated Encephalopathy

Zokirov M.M.,, Madjidova Y.N.

HIV infection is one of the most pressing medical and social problems in the whole world.
This article discusses one of the varieties of the complication of HIV infection such as HIV
associated encephalopathy. Clinical features and diagnostic criteria for the disease are
considered. Patients were examined using the Montreal cognitive function assessment
scale and symptomatic treatment with the nootropic drug choline alfoscerat

105-111 89 30

Immuno-Oriented Therapy In The Comprehensive Treatment Of Acute Pancreatitis

Safarov S.S.

The immuno-oriented effects of polyoxidonium and immunoglobulin in the complex
treatment of patients with acute pancreatitis were studied. Patients with acute pancreatitis
from the first days of the disease revealed violations of the immune status in the form of
the development of immunodeficiency. Complex therapy, including immunomodulin or
polyoxidonium, allowed approximation of the level of cytokines to those of healthy donors.
Studies allow us to recommend the inclusion of polyoxidonium and immunomodulin in the
basic, comprehensive conservative therapy of patients with acute pancreatitis for the
purpose of immunocorrective therapy.

48-51 102 23

Biological Action Of Direct Current

Muhiddin Halimovich Jalilov, Khudaikulova Shoira Narzullaevna,, Akhrorov Maruf Nasimovich

This work is devoted to the study of the effect of direct current on biological tissues, cells
and on the weight of the human body.The dielectric constant of certain substances and
the resistivity of organs is given. The course of physical and chemical changes under the
influence of direct current in cells, tissues and the entire body is indicated.

38-42 86 21

The State Of The Prostacycline-Thromboxane System In Patients With Ischemic Heart Disease

Khattahanova Rabiya Yuldashevna,

The aim of the work was to study the state of the prostacyclin-thromboxane system (PTS)
and platelet functions in patients with coronary heart disease (CHD). 86 patients with CHD
were examined. The state of PTS was examined by the content of prostacyclin and
thromboxane in the blood, determined by radioimmunological method. Platelet hemostasis
was studied by the aggregation properties of platelets and the platelet release reaction for
β-thromboglobulin determined by radio immunological method. In patients with IHD,
pronounced violations of the prostacyclin-thromboxane balance in the direction of the
predominance of thromboxane and an increase in the functional activity of platelets,
expressed in increased aggregation and platelet release reaction. In patients with IHD
with post infarction cardio sclerosis, the level of prostacyclin in the blood significantly
exceeds the level in patients without myocardial infarction. The content of prostacyclin and
thromboxane in the blood does not differ in patients with stable angina of functional
classes III and IY.