The immuno-oriented effects of polyoxidonium and immunoglobulin in the complex
treatment of patients with acute pancreatitis were studied. Patients with acute pancreatitis
from the first days of the disease revealed violations of the immune status in the form of
the development of immunodeficiency. Complex therapy, including immunomodulin or
polyoxidonium, allowed approximation of the level of cytokines to those of healthy donors.
Studies allow us to recommend the inclusion of polyoxidonium and immunomodulin in the
basic, comprehensive conservative therapy of patients with acute pancreatitis for the
purpose of immunocorrective therapy.
Averkiev V. L., Tarasenko V. S., Latysheva T. V. et al. Changes in some
immunological parameters in pancreatic necrosis and their correction // Surgery. 2003.
No. 5. P. 31-34.
Blagovestnov D.A. Et al., Prognostic significance of the parameters of the immune
response in the treatment of patients with acute pancreatitis, “Bulletin of new
technologies” - 2006 - T. XIII, No. 1 - p. 67
Bulava G.V., Abakumov M.M., Borovkova N.V. et al. Assessment of the severity of
immune disorders and prediction of the development of purulent-septic complications in
patients with emergency surgical pathology // Tomsk State University Journal. Surgery
them. I.I. Grekov. 2009.Vol. 168, No. 3. P. 10-16.
Borovkova N.V. Secondary immunodeficiency in purulent-septic complications of
surgical diseases: author. dis... doc. med. sciences. M., 2011.49 s.
Ermolov A. S., Borovkova N. V., Ivanov P. A. et al. Immunological assessment of
severity and prognosis of acute pancreatitis // Vestn. Surgery them. I.I. Grekov. 2005.V.
, No. 6. S. 22-28.
Tolstoy A. D., Popovich A. M. Immune disorders and methods of immuno-oriented
therapy in acute destructive pancreatitis // Terramedica. 2003. No. 4. P. 28-31.
SvistunovN. N., Ivlev VV On the possibility of predicting the outcomes of acute
pancreatitis with a severe course., “Bulletin of the St. Petersburg University.”, Ser. 11.
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