Communication Of Quality Of Life Indicators, Functional Methods Of Research And Neuromarker BNDF In Patients With Diabetes Mellitus 2 With Diabetic Foot Syndrome

HAC
inLibrary
Google Scholar
doi
 
  • Researcher, Department Of Diabetic Foot Of Purulent Complications Of Diabetes Mellitus, Republican Specialized Scientific And Practical Medical Center Of Endocrinology Named After Academician Y.Kh. Turakulova, 100125, Tashkent, Republic Of Uzbekistan
  • Doctor Of Medical Sciences, Head Of The Department Of Diabetic Foot Of Purulent Complications Of Diabetes Mellitus, Republican Specialized Scientific And Practical Medical Center Of Endocrinology Named After Academician Y.Kh. Turakulova, 100125, Tashkent, Republic Of Uzbekistan
CC BY f
12-23
19
7
To share
Alimkhanov Olimkhon Omilkhonovich, ., & Kamalov Telman Tulyaganovich, . (2021). Communication Of Quality Of Life Indicators, Functional Methods Of Research And Neuromarker BNDF In Patients With Diabetes Mellitus 2 With Diabetic Foot Syndrome. The American Journal of Medical Sciences and Pharmaceutical Research, 3(05), 12–23. https://doi.org/10.37547/TAJMSPR/Volume03Issue05-03
Crossref
Сrossref
Scopus
Scopus

Abstract

The purpose of the study is to study the correlation rate of the quality of life, electroneuromyography, doppler and neuro markers BNDF in the blood in patients with a type 2 of type with diabetic foot syndrome.

Methods: The following 2 groups of patients were formed: 1 gr. - SDS patients, neuropathic form -37 patients, 2 gr. - SDS patients, neuroichmic form -35 patients, 3 gr. - Control group, these are 20 healthy persons of the appropriate age and gender.

Results: In all groups of patients, the quality of life is significantly different in the FSHC questionnaire compared with the control group (p <0.05). In patients with a neuroecemic form of diabetic foot syndrome, a significant decrease was found (p <0.05). All indicators of doppler song vessels of legs compared with patients with neuropathic shape.

Revealed significant correlations of FSHK and laboratory and instrumental indicators. A correlation connection with the duration of the disease, the duration of the disease, the levels of glycemia of an empty stomach, the level of the glycated haemoglobin, BNDF in the blood, the speed of blood flow in the femoral artery, in the lower leg, is discovered.

The definition of neuromuscular transmission showed that the patients of the 1st and 2nd groups have a weak reduction in muscle contraction involuntarily. This confirmed the impairment of neuromuscular transmission in both groups.

Conclusions: 1) A questionnaire to determine the quality indicators - FSHK is the most sensitive and informative to determine the quality of life in patients with type 2 diabetes mellitus with neuropathic and neuroecemic forms

2) FSHP questionnaire can be used for dynamic assessment of type 2 diabetes patients with neuropathic and neuroecemic forms in outpatient clinical practice.

3) Revealed significant correlations of FSHK and laboratory and instrumental indicators. A correlation connection with the duration of the disease, the duration of the disease, the levels of glycemia on an empty stomach, the level of the glycated haemoglobin, BNDF in the blood, the speed of blood flow in the femoral artery, in the shin, M-answer when stimulating a tibial nerve.

 

 

Similar Articles

References

Beloedova, M.V. (2005). Improving the quality of life of gerontological patients with distal diabetic macroangiopathy by reducing the level of amputation (Doctoral dissertation, Moscow State University of Medicine and Dentistry).

Burkovsky, G.V., Kotsyubinsky, A.P., Levchenko, E.V., & Lomachenkov, A.S. (1995). Creation of the Russian version of the World Health Organization tool for measuring the quality of life. Problems of optimization of human lifestyle and health, 27-28.

Wasserman, L.I., & Trifonov, E.A. (2006). Methodology for studying the quality of life in the context of psychosomatic and somatopsychic relationships. VM Bekhterev Review of Psychiatry and Medical Psychology, (4), 12-15.

Wasserman, L.I., Gromov, S.A., Mikhailov, V.A., Lynnik, S.D., & Flerova, I.L. (2001). Rehabilitation and quality of life concepts: continuity and differences in modern approaches. In Psychosocial Rehabilitation and Quality of Life (pp. 103-115).

Kulaga, V.A. (2010). Results of lower limb amputations in critical ischemia (Doctoral dissertation, Military Medical Academy). P.137.

Malakhov, Yu.S. (2009). Surgical methods of treatment of ischemia of the lower extremities of the IV degree (Doctoral dissertation, speciality 14.00. 27 — surgery).

Mikhailov, V.G. (2005). Complex treatment of patients with ischemic diabetic foot complicated by gangrene (Doctoral dissertation, Moscow State University of Medicine and Dentistry). P.91.

Novik, A.A., & Ionova, T.I. (2007). Guidelines for the study of quality of life in medicine. 2nd edition/Under. ed. acad. RAMS Yul Shevchenko. Moscow: ZAO OLMA Media Group, 2007.320 p. Novik AA, Ionova TI Rukovodstvo po issledovaniyu kachestva zhizni v meditsine. 2-e izdaniye/Pod. red. Akad. RAMN Yu. L. Shevchenko. M .: ZAO "OLMA Media Grupp", 2007.320 s.

Golovina, G.M., & Savchenko, T.N. (2006). Subjective quality of life: approaches, assessment methods, applied research. Moscow: Publishing house of the Institute of Psychology RAS, 170.

Suprun, K.S. (2009). Influence of microcirculation disorders on the surgical tactics of treating diabetic foot syndrome. P.118.

Smirnova, L.M. (2010). Methodology and unified technology for assessing the functional effectiveness of prosthetics and orthotics in patients with lower limb pathology. SPb. P. 338.

Selezneva, E.V. (2004). Diagnostics and treatment of diabetic foot syndrome at the prehospital stage (Doctoral dissertation, speciality 14.00. 27 — surgery). P. 133.

Triandafilov, K.G. (2009). Surgical tactics and methods of surgical treatment of complicated diabetic foot syndrome (Doctoral dissertation, speciality 14.00. 27 — surgery). P. 162.

Argarini, R., McLaughlin, R. A., Joseph, S. Z., Naylor, L. H., Carter, H. H., Yeap, B. B., ... & Green, D. J. (2020). Optical coherence tomography: a novel imaging approach to visualize and quantify cutaneous microvascular structure and function in patients with diabetes. BMJ Open Diabetes Research and Care, 8(1), e001479. DOI: 10.1136/bmjdrc-2020-001479

Argarini, R., McLaughlin, R. A., Joseph, S. Z., Naylor, L. H., Carter, H. H., Haynes, A., ... & Green, D. J. (2020). Visualizing and quantifying cutaneous microvascular reactivity in humans by use of optical coherence tomography: impaired dilator function in diabetes. American Journal of Physiology-Endocrinology and Metabolism, 319(5), E923-E931. DOI: 10.1152/ajpendo.00233.2020. Epub 2020 Sep 21.

Bradley, C. (2001). Importance of differentiating health status from the quality of life. The Lancet, 357(9249), pp.7-8.

Chao, C. Y., & Cheing, G. L. (2009). Microvascular dysfunction in diabetic foot disease and ulceration. Diabetes/metabolism research and reviews, 25(7), 604-614. DOI: 10.1002/dmrr.1004.

Guyatt, G. H., Bombardier, C., & Tugwell, P. X. (1986). Measuring disease-specific quality of life in clinical trials. CMAJ: Canadian Medical Association Journal, 134(8), P.889.

Garratt, A. M., Ruta, D. A., Abdalla, M. I., Buckingham, J. K., & Russell, I. T. (1993). The SF36 health survey questionnaire: an outcome measure suitable for routine use within the NHS?. British Medical Journal, 306(6890), 1440-1444.

Hörnquist, J. O. (1982). The concept of quality of life. Scandinavian journal of social medicine, 10(2), pp. 57-61.

Hunt, S. M., McEwen, J., & McKenna, S. P. (1985). Measuring health status: a new tool for clinicians and epidemiologists. The Journal of the Royal College of General Practitioners, 35(273), pp.185-188.

Jenkinson, C., Fitzpatrick, R., & Argyle, M. (1988). The Nottingham Health Profile: an analysis of its sensitivity in differentiating illness groups. Social Science & Medicine, 27(12), pp.1411-1414.

Moons, P., Marquet, K., Budts, W., & De Geest, S. (2004). Validity, reliability and responsiveness of the" Schedule for the Evaluation of Individual Quality of Life–Direct Weighting"(SEIQoL-DW) in congenital heart disease. Health and quality of life outcomes, 2(1), pp.1-8.

Czajkowski, S. M., & McSweeny, A. J. (1996). The role of psychosocial factors in chronic obstructive pulmonary disease. Physical Medicine and Rehabilitation Clinics, 7(2), pp.341-352.

Neroev, V. V., Kiseleva, T. N., Okhotsimskaya, T. D., Fadeeva, V. A., & Ramasanova, K. A. (2018). Impact of antiangiogenic therapy on ocular blood flow and microcirculation in diabetic macular oedema. Vestnik oftalmologii, 134(4), 3-10. DOI: 10.17116/oftalma20181340413.

Polonsky, W. H. (2000). Understanding and assessing the diabetes-specific quality of life. Diabetes Spectrum, 13(1), P.36.

Rubin, R. R. (2000). Diabetes and quality of life. Diabetes Spectrum, 13(1), P.21.

Rosenthal, M. J., Fajardo, M., Gilmore, S., Morley, J. E., & Naliboff, B. D. (1998). Hospitalization and mortality of diabetes in older adults: a 3-year prospective study. Diabetes care, 21(2), pp.231-235.

Singh, H., & Bradley, C. (2006). Quality of life in diabetes. International Journal of Diabetes in Developing Countries, 26(1).

Snoek, F. J. (2000). Quality of life: a closer look at measuring patients' well-being. Diabetes Spectrum, 13(1), pp.24-28.

Surtees, P. G., Wainwright, N. W., Khaw, K. T., & Day, N. E. (2003). Functional health status, chronic medical conditions and disorders of mood. The British Journal of Psychiatry, 183(4), pp.299-303.

Vileikyte, L., Peyrot, M., Bundy, C., Rubin, R. R., Leventhal, H., Mora, P., ... & Boulton, A. J. (2003). The development and validation of a neuropathy-and foot ulcer-specific quality of life instrument. Diabetes care, 26(9), pp.2549-2555.

Wenger, N. K., Mattson, M. E., Furberg, C. D., & Elinson, J. (1984). Assessment of quality of life in clinical trials of cardiovascular therapies. American Journal of Cardiology, 54(7), pp.908-913.

Ware J.E., Kosinski M., Gandek B. (1993, 2000)/ SF-36 Health Survey: Manual and Interpretation Guide. Quality Metric Incorporated, Lincoln, RI. – 2000.

Wasserman, L. I., & Trifonova, E. A. (2006). Diabetes mellitus as a model of psychosomatic and somatopsychic interrelationships. The Spanish journal of psychology, 9(1), P.75.

inLibrary — это научная электронная библиотека inConference - научно-практические конференции inScience - Журнал Общество и инновации UACD - Антикоррупционный дайджест Узбекистана UZDA - Ассоциации стоматологов Узбекистана АСТ - Архитектура, строительство, транспорт Open Journal System - Престиж вашего журнала в международных базах данных inDesigner - Разработка сайта - создание сайтов под ключ в веб студии Iqtisodiy taraqqiyot va tahlil - ilmiy elektron jurnali yuridik va jismoniy shaxslarning in-Academy - Innovative Academy RSC MENC LEGIS - Адвокатское бюро SPORT-SCIENCE - Актуальные проблемы спортивной науки GLOTEC - Внедрение цифровых технологий в организации MuviPoisk - Смотрите фильмы онлайн, большая коллекция, новинки кинопроката Megatorg - Доска объявлений Megatorg.net: сайт бесплатных частных объявлений Skinormil - Космецевтика активного действия Pils - Мультибрендовый онлайн шоп METAMED - Фармацевтическая компания с полным спектром услуг Dexaflu - от симптомов гриппа и простуды SMARTY - Увеличение продаж вашей компании ELECARS - Электромобили в Ташкенте, Узбекистане CHINA MOTORS - Купи автомобиль своей мечты! PROKAT24 - Прокат и аренда строительных инструментов