Vol. 6 No. 06 (2024): Volume 06 Issue 06

In the context of insulin resistance syndrome, which encompasses changes in lipid and carbohydrate metabolism, liver-related issues are now being closely examined alongside cardiovascular diseases. Our research aimed to evaluate the predictive importance of non-alcoholic fatty liver disease (NAFLD) for identifying the likelihood of early atherosclerotic alterations in the carotid arteries. We discovered a connection between NAFLD and initial signs of atherosclerosis. By ranking prognostic factors that affect changes in the carotid artery wall, we've been able to develop a method for estimating individual atherosclerosis risk in people who are otherwise healthy. The practical value of our findings underscores the need for in-depth evaluation of individuals with NAFLD to identify risk factors that may contribute to the advancement of both liver and cardiovascular diseases.

Article explore the formulation and assessment of a novel nanoparticle-based topical gel containing the antifungal drug fluconazole. This study focuses on the design, preparation, and characterization of the nano-gel, aiming to improve drug delivery efficiency and therapeutic efficacy for the treatment of fungal infections. Through a combination of physicochemical characterization techniques, drug release studies, and in vitro and in vivo evaluations, the performance and efficacy of the nano-gel formulation are investigated. The results demonstrate the potential of the fluconazole-loaded nano-gel as a promising therapeutic approach for antifungal therapy, offering enhanced drug delivery and improved treatment outcomes.