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THE ROLE AND ISSUES OF EXPERIMENTAL SCIENTIFIC RESEARCH IN THE
FIELD OF MEDICINE
Termiz University of Economics and Service, Termez city, Farovon Massiv 43B
Asadbek Ahmadovich Qodirov
Medical Faculty, Treatment Field, 1st year
Feruza Abdusamatovna Umirqulova
e-mail:
Annotation
Experimental scientific research plays a crucial role in the development and testing of new
treatment methods, drugs, and technologies in medicine. These studies help assess effectiveness and
safety, and they also play a key role in better understanding diseases and developing effective
treatment approaches.However, such research requires significant technical resources, qualified
specialists, and financial support. It can also raise challenges such as ethical and safety concerns, the
complexity of clinical trials, and obtaining patient consent. Despite these issues, experimental
research holds great importance in advancing innovation in the field of medicine.
Keywords
: Experimental research, medicine, treatment methods, drugs, technologies, clinical
trials, safety, efficacy, ethical issues.
Introduction
Nowadays, many scientists are conducting research on theoretical and practical issues of
science in a systematic way. In our view, integrating theoretical ideas with practice and utilizing the
experience of great scientists in making discoveries and inventions holds significant importance. This
is because, during scientific research, individuals or teams contribute to innovations that influence
the advancement of society.Scientific research activity helps individuals better understand and
evaluate themselves — in other words, if a person wishes to become a true scientist, they must manage
their passions and ambitions, and make rational, effective, and optimal decisions. The results of such
activities manifest as discovery and creativity, which are shared with the public. This process opens
up new possibilities for analyzing, understanding, and evaluating scientific and creative
endeavors.Therefore, deeper exploration of approaches related to the scientific research process, as
well as identifying its unique features, is essential. In this regard, scientific research in the field of
medicine promotes the development of new treatment techniques, the in-depth study of diseases, and
offers both medical and moral healing to patients.
Precision Oncology: The "Best New Weapon" Against Cancer
.
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Precision oncology is described as the "best new weapon" in the fight against cancer,
according to Sizhen Wang, CEO of Genetron Health, in his blog for the World Economic Forum.
This approach involves studying the genetic structure and molecular characteristics of cancer signs
in patients. Identifying oncology indicates changes in cells that may contribute to the growth and
spread of cancer. Based on these findings, personalized treatment methods can then be developed.
The 100,000 Genomes Project
, an initiative by the National Health Service (NHS) in the
United Kingdom, successfully rised genomic data by analyzing more than 13,000 tumor kinds from
cancer patients to find more precise treatment options. This is because precision oncology treatments,
unlike conventional therapies such as chemotherapy, are targeted — which can result in less damage
to healthy cells and a reduction in side effects.Using immune cells to target and destroy cancer cells
was declared successful in 2022 for patients with leukemia.
Immunotherapy for Cancer: A Breakthrough in Leukemia Treatment
This treatment, known as CAR-T cell therapy, involves extracting immune cells —
specifically T cells — from cancer patients and genetically modifying them. The altered cells then
produce proteins called chimeric antigen receptors (CARs), which allow them to recognize and
destroy cancer cells. In the journal
Nature
, scientists from the University of Pennsylvania provided
with that two of the first patients treated with CAR-T cell therapy were still in long 12 years
later.Recently, the same journal announced that a woman who was treated with CAR-T therapy at the
age of four has remained in remission 19 years later.
CAR-T Cell Therapy: Long-Term Success in Pediatric Cancer Treatment
However, the U.S. Food and Drug Administration (FDA) is currently investigating whether
this process could actually cause cancer, as more than 30 cases of secondary cancers have been
identified in patients who received CAR-T therapy. Although it is not yet clear if the therapy is the
cause, precautionary warnings are now included on the drug packaging.
One of the beneficial sides of the clinical research is that they sometimes provide access to
advanced treatments and therapies that have not yet been made accessable to the people living there.
For many patients, especially those fighting diseases with limited treatment options, this offers a
chance to save their lives.For example, in the field of oncology, clinical trials often provide access to
new drugs and innovative therapies before they become widely available, as new cancer treatments
are constantly being developed. However, these treatments may include new chemotherapy drugs,
targeted therapies, or immunotherapies, which could offer significant benefits to patients facing a
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poor prognosis.Moreover, the care and detecting provided during clinical trials typically meet the
highest standards. However, participants usually undergo more frequent tests and detailed evaluations
compared to standard care conditions. This serious monitoring can lead to the early detection of
potential problems and better management of their health conditions.Furthermore, the successful
alliance between artificial intelligence (AI) and healthcare has led to improvements in patient health
across various areas, ranging from hospital efficiency and patient safety to quality medical treatment.
As a tool and technology, AI is used to check and visualize patient data, ensuring proficiensy
healthcare management. Numerous studies on the impact of AI on medical outcomes have yielded
beneficial and encouraging results. For example, healthcare professionals and patients are
increasingly using medical applications and evidence-based medicine, not just as part of remote
patient monitoring but also as a foundation for decision-making.One of the global challenges in the
pharmaceutical industry is how to treat rare diseases and discover new medications. Currently, only
10% of rare diseases are correctly treated, and more than 4,000 rare diseases remain untreated.
Although the low prevalence of rare diseases, there is a significant social need for research and
treatment of rare diseases in China, a country with a people of over 1.4 billion. There is currently a
serious shortage of treatment measures and options for rare diseases, and many patients suffering
from rare diseases around the world still do not receive timely and effective treatment.
Problems
Numerous studies show that undergraduate medical students often lack research knowledge
and interest. The research process, including data analysis, research design, and dissemination of
results, can be challenging for many medical students. Additionally, medical students may be less
engaged or interested, which can reduce their motivation to seek out research opportunities. Research
is fundamental to medicine and the cornerstone of providing quality healthcare to the public.
Therefore, a lack of knowledge and motivation can negatively impact the healthcare field. Current
research provides empirical data on the barriers and challenges to medical research among medical
students, shedding light on how involved or disengaged this group is with research at present.
Ongoing advancements in medicine are largely dependent on the education and work of
scientists dedicated to research in the health sciences. In this context, the participation of medical
scientists in research, particularly considering their clinically oriented education, plays a valuable
role. However, even in countries renowned for their scientific achievements, such as the United
States, it is becoming increasingly rare for physicians to choose to focus their careers on scientific
activities. One of the formulas that could help address this issue is to introduce future specialists to
the world of scientific research early during their academic education process. Furthermore, the
intersection between medical practice and academic research provides future specialists with an
opportunity to collaborate in shaping their medical education, contributing to the development of both
their clinical and scientific skills.
Solution
Numerous studies show that undergraduate medical students face a lack of interest and
knowledge in research. The research process, particularly data analysis and dissemination of results,
can be challenging for many students, which diminishes their motivation. Research is the foundation
of medicine, and its advancement greatly contributes to the development of healthcare. However,
even in scientifically advanced countries, physicians' interest in scientific research is declining.
Introducing future specialists to the world of scientific research early on encourages them to combine
scientific and clinical skills. This, in turn, helps achieve breakthroughs in medicine and contributes
to the advancement of healthcare.
Conclusion
Experimental research is crucial for developing innovations in medicine, although there are
technical, financial, and ethical limitations in its implementation. However, these studies play a key
role in creating new treatment methods and effectively treating patients.
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Used literatures
1.Victoria Masterson, Ian Shine, Madeleine North: Centre of Health and Healthcare;
2.
The Benefits of Clinical Trials: What You Need to Know.(September 23, 2024);
3.
Daniele Giansanti. Recent Advancements in Emerging Technologies for Healthcare
Management Operating system;
4
.
Challenges and Barriers to Medical Research Among Medical Students in Saudi Arabia.
(May 02, 2024);
5.
Nature
journal. (2022). "CAR-T Cell Therapy: A Revolutionary Approach to Cancer
Treatment."
Nature Publishing Group.
6. NHS. (2024). "Seven-Minute Cancer Treatment Injection Begins in the UK."
National
Health Service (NHS).
7. Wang, Sizhen. (2023). "Precision Oncology: The Best New Weapon Against Cancer."
World Economic Forum Blog.
8. The 100,000 Genomes Project. (2023). "Integrating Genomic Data to Advance Cancer
Treatment."
National Health Service (NHS).
9.
FDA
(2024). "FDA Investigates Potential Secondary Cancer Risks from CAR-T Therapy."
Food and Drug Administration.
