DOI:
https://doi.org/10.71337/inlibrary.uz.universaljurnal.111073Kalit so‘zlar:
biotexnologiya tabiiy dorilar biotransformatsiya o‘simliklar fermentativ reaksiya mikroorganizmlar ekologik xavfsizlik sanoat.Annotasiya
Ushbu tezisda biotexnologiya (organizm va mikroorganizmlardan foydalanish
orqali dorivor moddalar ishlab chiqarish usuli) yondoshuvi asosida tabiiy dorivor moddalarni
tayyorlashning zamonaviy metodikasi tahlil qilinadi. Tadqiqotda o‘simliklar manbai sifatida tabiiy
dorivor moddalar, mikroorganizmlarning biotransformatsiya (mikroorganizmlar yordamida tabiiy
moddalarning strukturaviy o‘zgarishi) jarayoni, biotexnologik usullarning afzalliklari muhokama
qilinadi. Shuningdek, ushbu yondashuvlar farmatsevtika sanoatining kelajak istiqbollari, ekologik
xavfsizlik va iqtisodiy samaradorlik nuqtai nazaridan tahlil qilinib, yangi preparatlarni yaratish va
mavjud o‘simlik resurslarini chuqur o‘rganishga qaratilgan.
Bibliografik manbalar
Kowalczyk, A., Wieczfinska, J., & Sitarek, P. (2020). Microbial Transformations of Plant Origin Compounds as a Step in Preparation of Highly Valuable Pharmaceuticals. Journal of Microbial & Biochemical Technology, 12(5), 311–319.
Wang, J.-F., Liu, S.-S., Song, Z.-Q., Xu, T.-C., Liu, C.-S., Hou, Y.-G., Huang, R., & Wu, S.-H. (2020). Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review. Molecules,
Shanu-Wilson, J., Evans, L., Wrigley, S., Steele, J., Atherton, J., & Boer, J. (2020). Biotransformation: Impact and Application of Metabolism in Drug Discovery. ACS Medicinal Chemistry Letters, 11(11), 2087–2107.
Mutafova, B., Mutafov, S., & Berkov, S. (2016). Microbial Transformations of Plant Origin Compounds as a Step in Preparation of Highly Valuable Pharmaceuticals. Biotechnology & Biotechnological Equipment, 30.
Tao, X., Li, Y., Zhang, J., Chen, S., & Xu, J. (2023). Application of Microbial Biocatalysts for Natural Compound Biotransformation. Catalysts, 13(3), 629. 6. Liu, Y., Zhang, Z., Wang, J., Li, H., & Zhang, H. (2024). A microbial platform for renewable natural product synthesis. Nature Communications, 15, Article 2147.
