DOI:
https://doi.org/10.71337/inlibrary.uz.universaljurnal.111136Kalit so‘zlar:
Candida albicans микробиота кишечника патогенность биоплёнки иммунный ответ кандидоз воспаление метаболические нарушения желудочно-кишечный тракт дисбиозAnnotasiya
Ushbu sharh qog'ozi Candida albicans, opportunistik xamirturushga o'xshash qo'ziqorinni o'rganadi, u oddiy inson mikroflorasining bir qismi bo'lib, immunitet gomeostazi buzilganida patogen bo'lish qobiliyatiga ega. Uning oshqozon-ichak trakti (GIT) faoliyatidagi roliga alohida e'tibor qaratiladi, bu erda C. albicans shilliq to'siqning yaxlitligini buzishi, biofilmlarni hosil qilishi, yallig'lanish reaktsiyalarini faollashtirishi va immunitet reaktsiyasini modulyatsiya qilishi mumkin. U C. albicansning ichak mikrobiotasi bilan o'zaro ta'siri, uning patogenlik mexanizmlari va organizmning tizimli holatiga, shu jumladan metabolik va immunitet buzilishlariga ta'siri haqidagi hozirgi tushunchalarni umumlashtiradi. U diagnostika yondashuvlari va terapevtik strategiyalar haqida ma'lumot beradi. Hujjat tegishli mahalliy va xorijiy manbalarni tahlil qilishga asoslangan.
Bibliografik manbalar
Neville, B. A., d'Enfert, C., & Bougnoux, M.-E. (2015). Candida albicans commensalism in the gastrointestinal tract. FEMS Yeast Research, 15(7), fov081. [PMCID: PMC7744392]
Новиков П.С., и др. (2019). Роль Candida albicans в развитии метаболических нарушений и пищевой гиперчувствительности. Российский иммунологический журнал.
Lin, J., Liu, S., Wang, W., et al. (2023). The interactions of Candida albicans with gut bacteria: a new understanding of gastrointestinal disease. Gut Pathogens, 15, Article 27. [DOI: 10.1186/s13099 -023-00559-8]
. Gulati, M., & Nobile, C. J. (2021). Candida albicans—The Virulence Factors and Clinical Manifestations of Infection. Journal of Fungi, 7(2), 151. [PMCID: PMC7912069]
Gow, N. A. R., et al. (2012). Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nature Reviews Microbiology.
Wu, T., et al. (2017). Gut microbiota and obesity: a new therapeutic target. International Journal of Molecular Sciences.
Cani, P. D., et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes.
Cavalheiro, M., & Teixeira, M. C. (2018). Candida biofilms: threats, challenges, and promising strategies. Frontiers in Medicine.
