DOI:
https://doi.org/10.71337/inlibrary.uz.universaljurnal.111398Kalit so‘zlar:
Shu munosabat bilan zamonaviy farmakologiyaning dolzarb vazifasi - izlash va yangi ureaza ingibitorlarini tabiiy manbalardan ayniqsa dan ajratib olish mikroorganizmlar va biologik faol birikmalar ishlab chiqaruvchi o'simliklar. Tabiiy metabolitlar yuqori biomoslashuvga ega bo'lishi mumkin va selektiv faoliyat bu ularni rivojlanish uchun istiqbolli nomzodlar qiladi yangi dorilarAnnotasiya
Ureaza bilan katalizlangan karbamid gidrolizi bir qator bakterial infektsiyalarning patogenezida asosiy rol o'ynaydi, chunki ureaza Helicobacter pylori, Ureaplasma urealyticum, Proteus mirabilis, Klebsiella spp kabi mikroorganizmlar uchun virulent omil hisoblanadi. va Pseudomonas spp. Ushbu bakteriyalarning yuqori ureaza faolligi siydik yo'llari infektsiyalari va oshqozon-ichak trakti kasalliklarining rivojlanishiga yordam beradi. So'nggi yillarda ureaza ingibitorlarini ureaza ishlab chiqaruvchi mikroorganizmlar bilan bog'liq infektsiyalarni davolash uchun terapevtik vositalar sifatida qo'llashga qiziqish ortib bormoqda. Biroq, adabiyotda tasvirlangan ma'lum bo'lgan ureaza inhibitörlerinin ko'pchiligi bir qator muhim cheklovlarga ega, jumladan, yuqori toksiklik, past o'ziga xoslik va klinik sharoitlarda etarli samaradorlik.
Bibliografik manbalar
Singh, R., Gautam, N., Mishra, A., & Gupta, R. (2020). Natural inhibitors of urease: Molecular docking and biochemical evidence. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 190–202.
Khan, A. L., et al. (2022). Endophytic fungi as potent bioresource for urease inhibitors. Applied Microbiology and Biotechnology, 106(4), 1437–1450.
Zhao, C., et al. (2021). Natural products as urease inhibitors: A review of recent progress. Phytochemistry, 183, 112651.
Saqib Bilal, Liaqad Ali, Abdul Latif Khan, Raheem Shahzad, Sajjad Asaf, Muhammad Imran, Sang-MoKnag, Sang Kuk Kim, In-Jung Lee. Endophytic fungus Paecilomyces Formosus LHL 10 produces sester- terpenoid YW3548 and cyclic peptide that inhibit urease and
α-glucosidase enzyme activities. Archives of Microbiology (2018) 200: 1493-1502
Mahnashi, M. H., Alqahtani, Y. S., Alqarni, A. O., et al. (2021). Urease inhibitory activity of phenolic compounds isolated from Aloe vera. International Journal of Molecular Sciences, 22(15), 8102.
