Authors

  • Giyazova Malika Muxamadovna

DOI:

https://doi.org/10.71337/inlibrary.uz.wsrj.92970

Keywords:

Keywords: oral cavity novel coronavirus infection COVID-19 periodontal pathology periodontitis clinical association oral probiotics Streptococcus salivarius

Abstract

Annotation. This scientific article is devoted to the study of changes in the organs and tissues of the oral cavity caused by the new coronavirus (SARS-CoV-2) infection during the COVID-19 pandemic. The effect of coronavirus on the oral cavity is comprehensive and complex, and various symptoms and pathological conditions can occur in this area. In this article, we will look at how COVID-19 infection causes inflammation, hardening, ulcers in the oral cavity and related tissues, as well as changes in oral hygiene and dental conditions. Studies show that the coronavirus affects not only the respiratory system, but also the oral cavity and its supporting structures, which can lead to medium- and long-term dental health problems.The article also presents pathological conditions in the oral cavity (for example, stomatitis, gingivitis, periodontitis) and their relationship with COVID-19, as well as recommendations aimed at improving the methods of clinical diagnosis and treatment of these changes. Expansion of information on the impact of COVID-19 on the oral cavity will allow dental workers and general practitioners to develop effective diagnostic and treatment strategies.


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World scientific research journal

https://scientific-jl.com/wsrj

Volume-38_Issue-1_April-2025

162

CHANGES IN ORGANS AND TISSUES OF THE ORAL

CAVITY IN NEW CORONAVIRUS INFECTION (COVID-19)

Giyazova Malika Muxamadovna

Bukhara State Medical Institute named after Abu Ali ibn Sino.

Bukhara, Uzbekistan. e-mail:

giyazova.malika@bsmi.uz

Annotation.

This scientific article is devoted to the study of changes in the

organs and tissues of the oral cavity caused by the new coronavirus (SARS-CoV-2)
infection during the COVID-19 pandemic. The effect of coronavirus on the oral cavity
is comprehensive and complex, and various symptoms and pathological conditions
can occur in this area. In this article, we will look at how COVID-19 infection causes
inflammation, hardening, ulcers in the oral cavity and related tissues, as well as
changes in oral hygiene and dental conditions. Studies show that the coronavirus
affects not only the respiratory system, but also the oral cavity and its supporting
structures, which can lead to medium- and long-term dental health problems.The
article also presents pathological conditions in the oral cavity (for example, stomatitis,
gingivitis, periodontitis) and their relationship with COVID-19, as well as
recommendations aimed at improving the methods of clinical diagnosis and treatment
of these changes. Expansion of information on the impact of COVID-19 on the oral
cavity will allow dental workers and general practitioners to develop effective
diagnostic and treatment strategies.

Keywords:

oral cavity, novel coronavirus infection, COVID-19, periodontal

pathology, periodontitis, clinical association, oral probiotics, Streptococcus salivarius

ПРИ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ (COVID-19)

ИЗМЕНЕНИЯ ОРГАНОВ И ТКАНЕЙ ПОЛОСТИ РТА

Гиязова Малика Мухамадовна

Бухарский государственный медицинский институт имени Абу Али ибн

Сино. Бухара, Узбекистан. e-mail:

giyazova.malika@bsmi.uz

Аннотация.

Данная научная статья посвящена изучению изменений в

органах и тканях полости рта при новой коронавирусной инфекции (SARS-
CoV-2) во время пандемии COVID-19. Воздействие коронавируса на полость
рта обширное и сложное, в этой области могут возникать различные симптомы
и патологические состояния. В этой статье мы рассмотрим, как инфекция
COVID-19 вызывает воспаление, уплотнение, язвы в полости рта и связанных с
ними тканях, а также как изменяется гигиена полости рта и стоматологические
состояния. Исследования показывают, что коронавирус поражает не только
дыхательную систему, но и полость рта и поддерживающие ее структуры, что


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может привести к средне- и долгосрочным проблемам со здоровьем зубов. В
статье также представлены патологические состояния полости рта (например,
стоматит, гингивит, периодонтит) и их связь с COVID-19, а также
рекомендации, направленные на улучшение методов клинической диагностики
и лечения этих изменений. Расширение информации о воздействии COVID-19
на полость рта позволяет стоматологическим работникам и врачам общей
практики разрабатывать эффективные стратегии диагностики и лечения.

Ключевые слова:

полость рта, новая коронавирусная инфекция, COVID-

19, патология пародонта, пародонтит, клиническая ассоциация, пероральные
пробиотики, Streptococcus salivarius

ЯНГИ КОРОНАВИРУС ИНФЕКЦИЯСИДА (CОВИД-19) ОҒИЗ БЎШЛИҒИ

АЪЗОЛАРИ ВА ТЎҚИМАЛАРИДАГИ ЎЗГАРИШЛАР

Гиязова Малика Мухамадовна

Абу Али ибн Сино номидаги Бухоро давлат тиббиёт институти. Бухоро,

Ўзбекистон. e-mail:

giyazova.malika@bsmi.uz

Аннотация.

Мазкур илмий мақола COVID-19 пандемияси даврида янги

коронавирус (SARS-CoV-2) инфектсиясининг оғиз бўшлиғи аъзолари ва
тўқималаридаги ўзгаришларни ўрганишга бағишланган. Коронавируснинг оғиз
бўшлиғига таъсири кенг қамровли ва мураккаб бўлиб, бу ҳудудда турли хил
симптомлар ва патологик ҳолатлар юзага келиши мумкин. Мақолада COVID-19
инфекциясининг оғиз бўшлиғи ва унга боғлиқ тўқималарда юзага келадиган
яллиғланиш, қаттиқлашиш, яралар, шунингдек, оғиз гигиэнаси ва стоматологик
ҳолатларнинг қандай ўзгаришини кўриб чиқамиз. Тадқиқотлар шуни
кўрсатадики, коронавирус нафақат нафас олиш тизимини, балки оғиз бўшлиғи
ва уни қўллаб-қувватловчи структураларни ҳам зарарлайди, бу эса ўрта ва узоқ
муддатли стоматологик саломатлик муаммоларига олиб келиши мумкин.
Мақолада шунингдек, оғиз бўшлиғидаги патологик ҳолатлар (масалан,
стоматит, гингивит, периодонтит) ва уларнинг COVID-19 билан боғлиқлиги,
шунингдек, бу ўзгаришларнинг клиник диагностика ва даволаш методларини
яхшилашга қаратилган тавсиялар тақдим этилади. COVID-19 нинг оғиз
бўшлиғига таъсири ҳақида маълумотларни кенгайтириш, стоматологик
ходимларга ва умумий амалиёт шифокорларига самарали диагностика ва
даволаш стратегияларини ишлаб чиқиш имконини беради.

Калит сўзлар:

оғиз бўшлиғи, янги коронавирус инфекцияси, COVID-19,

пародонт патологияси, пародонтит, клиник ассоциация, оғиз орқали қабул
қилинадиган пробиотиклар, Streptococcus salivarius


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The COVID-19 pandemic has had a significant impact on the global healthcare

system worldwide. Infection with the coronavirus (SARS-CoV-2) usually negatively
affects such systems as the respiratory, nervous, and cardiovascular systems, but new
research, including changes in the oral cavity and its tissues, including teeth, tongue,
nasal passages, and salivary glands, is also receiving special attention.

The oral cavity is very important for COVID-19, since the SARS-CoV-2 virus

can enter a person through the mouth and multiply there. The virus can also spread to
various tissues of the oral cavity, including the salivary glands, gums, tongue, and
nasal passages. This problem exacerbates oral health and can lead to the development
of new diseases.

A decrease or deterioration in saliva production was observed in patients with

COVID-19. This condition may be associated with xerostomia (dry mouth) and may
increase the activity of bacteria and fungi in the mouth, resulting in oral infections.

Changes in gingiva and periodontal system in patients with COVID-19,

inflammation of the dental pulp (gingivitis) and periodontal system was observed.
These conditions can lead to bleeding in the mouth, red and swollen dental flesh, and
increased pain.

Language Changes infection with the coronavirus can cause swelling, pain,

discoloration of the tongue, and sometimes pink or white coating on the surface of the
tongue. These changes are visible in patients with COVID-19, but this condition
differs depending on the impact on the oral cavity of patients.

Nasal passages the virus can also multiply in the nasal passages, where it enters

the oral cavity through nasal droplets. In addition, the appearance of inflammation
and discomfort in the nasal passages indicates the effect of COVID-19 on the nasal
and respiratory systems in patients.

Teeth do not have any protective mechanisms against COVID-19 infection.

Many COVID-19 patients experience problems, especially with the oral cavity and
teeth. Teeth can especially multiply excess bacteria that multiply inflammations and
infections. Therefore, it is important to regularly brush your teeth and disinfect your
mouth.

The COVID-19 pandemic has had a major impact on healthcare systems around

the world. The spread of the SARS-CoV-2 coronavirus virus has led to significant
changes not only in the respiratory tract but also in the oral cavity and related tissues
(e.g., tongue, teeth, nose, throat). This analysis aims to analyze the changes caused by
COVID-19 in the oral cavity and related structures, and to analyze these changes
based on scientific literature.

There are several studies on the effects of COVID-19 on the oral cavity and

related organs. ACE2 receptors, which are the main entry point of the SARS-CoV-2
virus, are also present in the tissues of the oral cavity. This is the main mechanism by


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which the virus penetrates these areas and causes various changes. Studies have
shown that many patients experience dry mouth, sore throat, and dental problems.

Changes in the tissues of the oral cavity are associated with many mechanical

and chemical factors. In patients with coronavirus, losses, injuries, and inflammation
of the oral mucosa were observed. These conditions often depend on the patient's
general condition and the immune system's response. At the same time, the associated
effects of COVID-19 on the bacterial flora of the mouth have also been shown, which
can have an even more negative impact on oral health.

There are reports of the impact of COVID-19 on teeth. Some studies, especially

showing the interaction of the virus with the microflora of the oral cavity, emphasized
that it causes inflammation, swelling, and bleeding in the teeth and periodontal
tissues. undefined

Preventive measures are important to prevent the health of the oral cavity from

being affected by COVID-19. Regular oral cleansing, prevention of bacterial
inflammation, and treatment with antiseptics and anti-inflammatory drugs have
shown beneficial results in many cases.

Although the effects of COVID-19 on the oral cavity and related tissues have

not yet been fully studied, the available literature indicates that this virus negatively
affects not only the respiratory tract, but also the mouth and its structures (teeth,
tongue, throat, and periodontal tissues). The relationship between the oral health
status of patients, the degree of infection with the virus, and its effect on the general
immune system is presented. At the same time, a more in-depth study of the impact
of COVID-19 on the oral cavity and its tissues may be important in the prevention
and treatment of this disease. New scientific research will help to identify changes in
the oral cavity and develop effective treatment methods.

Литературы:

1.

Brock M, Bahammam S, Sima C. The Relationships Among Periodontitis,
Pneumonia and COVID-19. Front Oral Health. 2022;2:801815.

2.

Salas Orozco MF, Niño-Martínez N, Martínez-Castañón GA, et al. Presence of
SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic
Review. Medicina (Kaunas). 2021;57(6):523.

3.

Gupta S, Mohindra R, Chauhan PK, et al. SARS-CoV-2 detection in gingival
crevicular fluid. J Dent Res. 2021;100(2):187-93.

4.

Sahni V. SARS CoV-2 load in periodontal disease. J Am Dent Assoc.
2022;153(1):14.

5.

Berton F, Rupel K, Florian F, et al. Dental calculus: a reservoir for detection of
past SARS-CoV-2 infection. Clin Oral Investig. 2021;25(8):5113-4.


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6.

Gomes SC, Fachin S, da Fonseca JG, et al. Dental biofilm of symptomatic
COVID-19 patients harbours SARS-CoV-2. J Clin Periodontol. 2021;48(7):880-
5.

7.

Gupta S, Mohindra R, Singla M, et al. The clinical association between
Periodontitis and COVID-19. Clin Oral Investig. 2022;26(2):1361-74.

8.

Brandini DA, Takamiya AS, Thakkar P, et al. Covid-19 and oral diseases:
Crosstalk, synergy or association? Rev Med Virol. 2021;31(6):e2226.

9.

Iranmanesh B, Khalili M, Amiri R, et al. Oral manifestations of COVID-19
disease: A review article. Dermatol Ther. 2021;34(1):e14578.

10.

Daly J, Black EAM. The impact of COVID-19 on population oral health.
Community Dent Health. 2020;37(4):236-8.

11.

Martín Carreras-Presas C, Amaro Sánchez J, López-Sánchez AF, et al. Oral
vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis.
2021;27(Suppl. 3):710-2.

12.

20. Cuevas-Gonzalez MV, Espinosa-Cristóbal LF, Donohue-Cornejo A, et al.
COVID-19 and its manifestations in the oral cavity: A systematic review.
Medicine (Baltimore). 2021;100(51):e28327.

13.

Farid H, Khan M, Jamal S, Ghafoor R. Oral manifestations of Covid-19-A
literature review. Rev Med Virol. 2022;32(1):e2248.

14.

Eghbali Zarch R, Hosseinzadeh P. COVID-19 from the perspective of dentists:
A case report and brief review of more than 170 cases. Dermatol Ther.
2021;34(1):e14717.

15.

Surboyo MD, Ernawati DS, Budi HS. Oral mucosal lesions and oral symptoms
of the SARS-CoV-2 infection. Minerva Dent Oral Sci. 2021;70(4):161-8.

16.

Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral
Manifestations in Patients with COVID-19: A 6-Month Update. J Dent Res.
2021;100(2):141-54.

References

Brock M, Bahammam S, Sima C. The Relationships Among Periodontitis, Pneumonia and COVID-19. Front Oral Health. 2022;2:801815.

Salas Orozco MF, Niño-Martínez N, Martínez-Castañón GA, et al. Presence of SARS-CoV-2 and Its Entry Factors in Oral Tissues and Cells: A Systematic Review. Medicina (Kaunas). 2021;57(6):523.

Gupta S, Mohindra R, Chauhan PK, et al. SARS-CoV-2 detection in gingival crevicular fluid. J Dent Res. 2021;100(2):187-93.

Sahni V. SARS CoV-2 load in periodontal disease. J Am Dent Assoc. 2022;153(1):14.

Berton F, Rupel K, Florian F, et al. Dental calculus: a reservoir for detection of past SARS-CoV-2 infection. Clin Oral Investig. 2021;25(8):5113-4.

Gomes SC, Fachin S, da Fonseca JG, et al. Dental biofilm of symptomatic COVID-19 patients harbours SARS-CoV-2. J Clin Periodontol. 2021;48(7):880-5.

Gupta S, Mohindra R, Singla M, et al. The clinical association between Periodontitis and COVID-19. Clin Oral Investig. 2022;26(2):1361-74.

Brandini DA, Takamiya AS, Thakkar P, et al. Covid-19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. 2021;31(6):e2226.

Iranmanesh B, Khalili M, Amiri R, et al. Oral manifestations of COVID-19 disease: A review article. Dermatol Ther. 2021;34(1):e14578.

Daly J, Black EAM. The impact of COVID-19 on population oral health. Community Dent Health. 2020;37(4):236-8.

Martín Carreras-Presas C, Amaro Sánchez J, López-Sánchez AF, et al. Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis. 2021;27(Suppl. 3):710-2.

20. Cuevas-Gonzalez MV, Espinosa-Cristóbal LF, Donohue-Cornejo A, et al. COVID-19 and its manifestations in the oral cavity: A systematic review. Medicine (Baltimore). 2021;100(51):e28327.

Farid H, Khan M, Jamal S, Ghafoor R. Oral manifestations of Covid-19-A literature review. Rev Med Virol. 2022;32(1):e2248.

Eghbali Zarch R, Hosseinzadeh P. COVID-19 from the perspective of dentists: A case report and brief review of more than 170 cases. Dermatol Ther. 2021;34(1):e14717.

Surboyo MD, Ernawati DS, Budi HS. Oral mucosal lesions and oral symptoms of the SARS-CoV-2 infection. Minerva Dent Oral Sci. 2021;70(4):161-8.

Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral Manifestations in Patients with COVID-19: A 6-Month Update. J Dent Res. 2021;100(2):141-54.