YOSH OLIMLAR
ILMIY-AMALIY KONFERENSIYASI
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65
PROBLEMS OF DIAGNOSIS OF HYPERANDROGENISM SYNDROME
G.O. Saidova
D.B. Asrankulova
Andijan State Medical Institute
https://doi.org/10.5281/zenodo.15244396
Hyperandrogenemia is a common endocrine disorder. Hyperandrogenism syndrome
refers to conditions associated with excessive production of androgen hormones in women.
These conditions lead to metabolic pathology, hirsutism, menstrual cycle disorders,
miscarriage, and infertility.
Research objective.
To identify problems in the diagnosis of hyperandrogenism
syndrome through an analysis of modern literature.
Materials and methods.
A search was conducted in the literature and open databases
among publications over the past 5 years. More than one hundred thousand publications on the
problem were identified, and the most relevant ones were selected from among them.
Results.
Hyperandrogenism is divided into three types: idiopathic, receptor, transport,
and iatrogenic. Idiopathic hyperandrogenism is characterized by an increase in the amount of
androgens detected by laboratory tests. The receptor form is accompanied by an increase in
the number and sensitivity of androgen “target” receptors. In the transport form, there is a
violation of the function of blood proteins that bind testosterone. The iatrogenic form is
associated with the intake of drugs with androgenic properties. The American and European
reproductive medicine societies have recommended the use of clinical, laboratory and
ultrasound examinations in the diagnosis of hyperandrogenism syndrome. However, the
principles inherent in the forms of hyperandrogenism and their various clinical manifestations
are still not fully described in the literature.
Conclusion.
Biochemical confirmation of hyperandrogenemia is not the final, but the
initial stage of the examination, therefore, a differential diagnostic approach is required to
search for its causes. Despite the wide possibilities of methods for diagnosing
hyperandrogenism syndrome, the development of early diagnostic principles specific to its
forms and various clinical manifestations is one of the important problems for gynecological
practice.
