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cholecystitis was substantiated by normalizing the MSM parameters E254 and E280;
peroxidation processes: MDA, catalase, glutathione peroxidase, SOD; elimination of
dysbiosis: fungi of the genus Candida, Staphylococcus aureus and secondary
immunodeficiency of local protective factors by increasing the level of sIgA; titer of
lysozyme, an indicator of phagocytosis.
Литература.
1.Камилов, X., Кадырбаева, А., Бахрамова, Ф., & Мирзаев, X. (2021).
Клиническая картина, диагностика и лечение хронического рецидивирующего
афтозного стоматита. Stomatologiya. (2 (83)). 64-67.
2.Алимова, Д. М., and X. П. Камилов. Повышение эффективности лечения
рецидивирующего афтозного стоматита с применением озона. Diss, автореф.
дис.... д. ф. н.—Ташкент: ТГСИ, 2018.—25—41 с, 2018.
3.Ибрагимова, М. X., and С. Р. Камилова. "Состояние микробиоценоза и
местного иммунного статуса больных ХРАС при хроническом калькулезном
холецистите." Актуальные проблемы стоматологии Материалы. 86-92.
4.Алимова, Д., Абдуллаева, М., Юлдашева, Н., & Таджиева, К. (2021).
ОПТИМИЗИРОВАННЫЕ ПОДХОДЫ К КОМПЛЕКСНОМУ ЛЕЧЕНИЮ
ПАЦИЕНТОВ С ХРОНИЧЕСКИМ РЕЦИДИВИРУЮЩИМ АФТОЗНЫМ
СТОМАТИТОМ. Stomatologiya, 1(1 (82)), 53-56.
5.Khabbazi, Alireza, et al. "A comparative study of vitamin D serum levels in
patients with recurrent aphthous stomatitis." The Egyptian Rheumatologist 37.3 (2015):
133-137.
6.Камилов, X., M. Ибрагимова, and H. Убайдуллаева. "Современный взгляд
на этиопатогенез, диагностику лечение хронического рецидивирующего
афтозного стоматита при хроническом холецистите (обзор литературы)."
Медицина и инновации 1.1 (2021): 80-86.
7.Алимова, Д. М., and У. А. Шукурова. "Перекисное окисление и
антиоксидантная система слюны у больных рецидивирующим афтозным
стоматитом." Врач-аспирант 41.4.2 (2010): 265-269.
METHODS FOR DIAGNOSTICS OF INFLAMMATORY - DESTRUCTIVE
PERIODONTAL LESIONS
Kamilov Kh.P., Takhirova K.A., Abduganiev U.B., Fozilova L.
Tashkent State Dental Institute
The purpose of the research.
The aim of the study is to expand the capabilities
of clinical laboratory medicine, improve diagnostic panels, significant progress in the
field of fundamental sciences, the effectiveness and consistency of interdisciplinary
interaction, the widespread introduction of modern technologies create prerequisites for
revising the role of oral fluid (OM) in the life processes of the div (A.V. Avdeev ,
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60
2012; N. B. Zakharova, 2015; L. N. Kazarina, 2016; E. V. Kondyurova, 2018; S. V.
Averyanov, 2018; G. F. Beloklitskaya, 2019; Y. Furuichi, 2019).
Materials and methods of research -
to solve the tasks set will be used: clinical,
hygienic, microbiological, static and biochemical research methods.
Results of the research.
The results of the study of the etiology and pathogenesis
of periodontal diseases in children and adolescents are very ambiguous. Thus, the role
of microbial, traumatic, immune, vascular and other factors has been comprehensively
studied. However, extremely important for understanding the development of
periodontal pathology is the knowledge of the ratio of internal and external factors,
which were pointed out by Arkovy back in 1903. The etiological factor almost never
manifests itself as one «specific culprit» and only one specific disease, it does not just
affect the div, but interacts with it.
Conclusion.
The use of biochemical indicators makes it possible to determine
the intensity of inflammatory and destructive changes in periodontal tissues in patients,
depending on the diagnosis, objectively assessing both pathological changes and the
effect of ongoing anti-inflammatory therapy in dynamics.
Литература.
1.Камилов, X., et al. ’’ДИАГНОСТИКА ПРЕДРАКОВЫХ ЗАБОЛЕВАНИИ
СЛИЗИСТОЙ ПОЛОСТИ РТА.” Stomatologiya 2 (83) (2021): 17-18.
Камилов, X. И., and Т.Э. Зойиров. "Состояние системы гемостаза при пародонтите
у больных ревматоидным артритом.” Врач-аспирант 41.4 (2010): 79-83.
2.Ибрагимова, М. X. Тактика диагностики и лечения заболеваний слизистой
оболочки полости рта и пародонта при патологии гепатобилиарной системы. Diss.
Автореф. дис.... д-ра мед. наук, 2019.
3.Нигматов, Р. Н., Н. Юлдашева, and Н. Р. Нигматова. "Состояние костной
ткани пародонта у больных с заболеваниями внутренних органов.” B
ICHUK
стоматолога 2 (2008): 58-62.
4.Gafforov, Sunnatullo A., et al. "Clinical characteristics and diagnosis of chronic
generalized periodontitis in patients with connective tissue dysplasia.” Russian Journal
of Dentistry 26.3 (2022): 219-228.
5.Усманова, Шайра Равшанбековна, and Абдугаффур Ахатович Хаджиметов.
"Патогенетические особенности течения генерализованного пародонтита у
пациентов с хроническим нарушением мозгового кровообращения.” Казанский
медицинский журнал 97.5 (2016): 720-723.
6.Takhirova, Kamolakhon Abrorovna, and Khaydar Pazilovich Kamilov. ’’Analysis
of the state of microcirculation in patients with chronic generalized parodontitis."
EUROPEAN RESEARCH: INNOVATION IN SCIENCE, EDUCATION AND
TECHNOLOGY. 2019.
7.Мелькумян, T. B., and А. Д. Дадамова. "Актовегин при лечении хронического
генерализованного пародонтита легкой-средней степени тяжести." Новое в
стоматологии 1 (2003): 60.
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61
8.Pizzo, Giuseppe, et al. "Effect of hormone replacement therapy (HRT) on
periodontal status of postmenopausal women." Medical Science Monitor: International
Medical Journal of Experimental and Clinical Research Y1A (2011): PH23.
9.Даминова, H., Шорасулов, Ш., Ганиева, X., & Бобоев, A. (2021). Клинические
особенности воспалительных заболеваний пародонта у больных пузырчаткой.
Медицина и инновации, 7(1), 122-124.
10.Hamidullaevna, Yusupalikhodjaeva Saodat, and Bekjanova Olga Esenovna.
"Pathogenetic aspects of treatment of periodontitis associated with Candida infection in
patients with diabetes mellitus." European science review 1-2 (2016): 134-135.
11.Shukurova, U. A., et al. "Local phytotherapy of chronic generalized periodontitis."
ACADEMICIA: An International Multidisciplinary Research Journal 11.4(2021): 122-
128.
FACTORS ASSOCIATED WITH PLASMA IL-6 LEVELS
IN HIV-POSITIVE PEOPLE
Karimov D.A., Akhmedjanova Z.I., Nazarova M.F., Begmatov B.X.
Tashkent state dental institute,
Institute of immunology and human genomics
Background
. Elevated interleukin 6
(IL-6) levels have been linked to
cardiovascular disease, cancer and death. Persons with human immunodeficiency virus
(HIV) infection receiving treatment have higher IL-6 levels, but few data are available
on factors associated with circulating IL-6.
Materials and methods of the research
. Participants in the study with IL-6
measured at baseline were included (N=48). Factors associated with IL-6 were
identified by linear regression. Demographic and HIV variables (nadir/entry CD4+cell
count, HIV RNA level, antiretroviral therapy regimen) were investigated in the study.
In the study, CD4/CD8 ratio, smoking, comorbid conditions, viral load and educational
level were assessed.
Results of the research
. Demographics associated with higher IL-6 levels were
older age and lower education. Higher HIV RNA levels were associated with higher IL-
6 levels, and higher nadir CD4+ cell counts with lower IL-6 levels. Compared with
efavirenz, protease inhibitors were associated with higher and nevirapine with lower IL-
6 levels. Smoking and all comorbid conditions were related to higher IL-6. IL-6 levels
increased with decreasing eGFR and decreasing serum lipids.
Conclusions
. Higher levels of IL-6 were associated with older age, higher div
mass index, HIV replication, low nadir CD4+ cell count, protease inhibitor use,
comorbid conditions, and decreased eGFR. Multiple factors affect inflammation in HIV
and should be considered in studies of IL-6 as a biomarker of clinical outcomes.
SUT TISHLARNI VAQTIDAN OLDIN OLINISHI SABABLI YUZAGA
