Vol. 5 No. 04 (2025): Volume 05 Issue 04

Metabolic syndrome is a complex cluster of conditions including obesity, insulin resistance, dyslipidemia, and hypertension, which significantly increase the risk of cardiovascular disease and type 2 diabetes. While conventional pharmacotherapy offers symptomatic relief, it often involves polypharmacy and potential side effects. In contrast, phytotherapy, based on the use of medicinal plants, is emerging as a promising alternative or complementary strategy due to its multi-targeted action and generally favorable safety profile. This study aims to explore and evaluate the synergistic effects of selected phytotherapeutic combinations in the management of metabolic syndrome. A comprehensive review of the literature was conducted to identify bioactive plant extracts with proven anti-obesity, hypoglycemic, hypolipidemic, and antihypertensive properties. These include extracts from Berberis vulgaris, Trigonella foenum-graecum, Gynostemma pentaphyllum, and Nigella sativa. Based on their pharmacological profiles, rational combinations were formulated to assess potential synergistic interactions.

Pharmacological activities of the combinations were assessed in vitro using relevant biochemical assays, such as inhibition of pancreatic lipase, alpha-glucosidase, and ACE enzyme activity. Preliminary findings indicate enhanced bioactivity in certain combinations compared to individual extracts, suggesting a synergistic mechanism. Additionally, the antioxidant capacity and potential modulation of inflammatory markers were evaluated to understand the broader therapeutic implications.

This research contributes to the growing body of knowledge supporting the use of multi-herbal combinations as a holistic approach to managing metabolic syndrome. Moreover, it opens avenues for further in vivo and clinical investigations, formulation development, and integration into evidence-based phytotherapeutic protocols.

This article describes the prevalence and clinical features of 105 patients with chronic hepatitis. As a result of the study, it was found that the disease is more common in women and the different picture of subjective or objective symptoms is higher in patients.

Enterosorbents are widely used in gastroenterology, toxicology, infectious diseases, allergology, dermatology, surgery, oncology, hepatology, nephrology, and addiction medicine.

To expand the range of enterosorbent preparations using natural raw materials, the physicochemical and technological properties of the natural mineral glauconite were studied as a promising source for the developing granulated, encapsulated, and tablet-form oral enterosorbent preparations.

This article analyzes the role of modeling technologies for biological problems in developing students' critical thinking skills in medical education. Modeling technologies provide an opportunity to understand complex biological processes, analyze problems, and develop alternative solutions. The article also examines the main types of modeling, their advantages in forming critical thinking, and their effectiveness in the medical education process. The results of the study show that the use of modeling technologies serves to deepen students' knowledge, develop analytical thinking, and increase their independent decision-making skills.

One of the most prevalent gastrointestinal disorders is duodenal ulcers. Approximately 5–10% of people worldwide will at some point in their lives suffer with this illness. There are two to three times as many males as females. Between the ages of 30 and 50, more develops. Disease rates are high in industrialized nations like Uzbekistan, the US, and Europe. Although the illness is very uncommon in Asia and Africa, Helicobacter pylori infections are quite common in places with inadequate sanitation. Ninety-five percent of cases are caused by Helicobacter pylori infection. Fast food that is hot, salty, and greasy causes malnutrition. Nervousness and psychological aspects. Bidens and Achillea are used to treat duodenal ulcers. When it comes to gastrointestinal disorders, the herbs Bidens and Achillea are said to be quite beneficial. They have antibacterial, anti-inflammatory, and wound-finishing properties. A solution containing 14.286 mg/L of each vitamin was created after the first 200 µL of B1, B6, B3, B12, and PP were removed. This led to the creation of standard solutions with 7.143, 3.571, and 1.786 mg/l. Standard vitamin C solutions with concentrations of 286, 143, 71.5, and 57.2 mg/l were also prepared. Pure water with a concentration of 0 mg/l was used to construct a calibration graph.

This article explores the impact of modern technologies, specifically 3D printing and virtual reality (VR), on the fields of anatomy and surgery. By reviewing recent studies, the article highlights how these technologies enhance anatomical education, improve surgical training, and lead to better clinical outcomes. The effectiveness of 3D-printed models and immersive VR experiences in teaching complex anatomical concepts is discussed, along with their applications in surgical practice. Furthermore, the article addresses challenges and limitations in adopting these innovative approaches in medical education.

COVID-19, typically regarded as a respiratory illness, exhibits substantial neurological involvement, especially in severely affected patients. Acute cerebrovascular events, including ischemic and hemorrhagic strokes, are seen in relatively young, previously healthy individuals, linked to hypercoagulability and prothrombotic states. Neurological complications of COVID-19 may arise without direct central nervous system infection, stemming from a severe systemic reaction to the infection. Further research into the pathophysiology and clinical trials are needed to optimize strategies preventing long-term consequences and therapeutic choices.

The concept of sex chromatin plays an important role in genetics, cytology and medical practice. Sex chromatin is a condensed inactive X chromosome in the nucleus of somatic cells in female mammals. This phenomenon is explained by a dosage compensation mechanism that ensures equal amounts of X-sex chromosome gene products in males and females. Sex chromatin is an important object of cytogenetic studies, allowing the diagnosis of disturbances in the number of X-sex chromosomes and the differential diagnosis of hereditary chromosomal diseases.

The article discusses the importance of involving professors, teachers and employees of the Institute for Retraining and Advanced Training of Specialists in Physical Education and Sports in sports. This process, in turn, is aimed at strengthening their health and ensuring their physical development. Based on the analysis of anthropological indicators, the positive effect of physical activity was identified in the studies. The results of this analysis were reflected in research works that help to further explain the importance of physical education and sports.

This article covers the psychological basis of tactical training of athletes, the conclusion of an approximate tactical plan.

The study of retinal diseases and the development of treatments for conditions such as age-related macular degeneration (AMD) requires reliable and reproducible cell culture models. Porcine retinal pigment epithelium (RPE) cells have been widely used due to their similarities to human RPE cells, making them an ideal model for retinal studies. However, developing a standardized and reproducible protocol for culturing these cells remains a challenge. This article presents a validated protocol for cultivating single-eye porcine RPE cell cultures, ensuring consistency and reproducibility across experiments. The protocol addresses key considerations, including tissue isolation, cell maintenance, and characterization of the cultured cells, providing a useful resource for researchers in retinal biology and ophthalmology.

This article provides an in-depth analysis of the sales of adaptogenic drugs in the pharmaceutical market of Uzbekistan for the period 2021-2024. Key trends, changes in the market structure, the dynamics of the range of pharmaceutical forms, pricing policy, and further development prospects were studied. Special attention was paid to import dependence, localization of production, and the introduction of new technologies. The presented data are visualized in the form of diagrams and graphs.