91
EFFICACY OF MICROPULSE LASER THERAPY IN THE
COMPREHENSIVE TREATMENT OF CENTRAL SEROUS
CHORIORETINOPATHY
Adkhamova L.A. Free applicant for the department of the Department of Ophthalmology
Scientific Advisor: Tuichibaeva D.M., DSc, Associate Professor of the
Department of Ophthalmology Tashkent State Dental Institute, Uzbekistan.
Central Serous Chorioretinopathy (CSCR) is a disease characterized by multifactorial
etiology, operating through a pathogenic mechanism and its relationship with systemic
processes depending on the situation. At the core of these phenomena lies the development of
serous detachment of the neurosensory layer of the retina, associated with impaired barrier and
pumping functions of the retinal pigment epithelium (RPE), increased permeability of Bruch's
membrane, as well as leakage of fluid from the choriocapillaris through the RPE into the
subretinal space.
Objective of the study:
to develop a comprehensive approach to the treatment of patients
with central serous chorioretinopathy by improving the technique of micropulse laser therapy
and platelet-rich autologous plasma injection.
Materials and methods:
a total of 30 eyes of patients with CSCR were examined. After
determining the subthreshold laser exposure mode for the macular area of the retina, laser
applications were performed using a 577 nm wavelength laser with the following parameters:
spot diameter – 100 µm, duty cycle – 10%, exposure – 20 ns, power – 100 mW, number of
applications – 400. On the following day after laser treatment, a course of injections of platelet-
rich autologous plasma (with a concentration of 900×10³ cells/mL) was administered in a dose
of 1.0 mL via parabulbar injection.
Results.
The main criteria for the effectiveness of the treatment were improvement in
visual acuity: from an average of 0.6 before treatment to an average of 0.7 after treatment;
improvement in the cytoarchitecture of the retina according to optical coherence tomography
(OCT): reduction in the height of macular edema (from an average of 313 µm before treatment
to an average of 260 µm after treatment); reattachment of the neuroepithelium. All patients in
the group reported subjective improvement in visual function.
Conclusions.
The therapy led to both objective and subjective improvement in visual
function, reduction in the height and area of neuroepithelial detachment, restoration of the
foveolar depression profile based on OCT findings, and blockage of leakage points as shown
by fluorescein angiography (FA).
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