Peculiarities of the morphology of adenohypophysis during introduction of hederagenin to experimental animals are presented. Hederagenin is a non-sugar part of the triterpene glycoside ladylginoside with hypolipidemic and antiatherosclerotic activities, which has been proved by earlier comprehensive studies. Investigations of this orientation substances remain highly relevant, since cardiovascular diseases, many of which are based on vascular atherosclerosis, continue to lead as a cause of death worldwide. Given the established possible mechanism of the antiatherosclerotic property of ladyginoside mediated through increased thyroid function, the effect of the aglycon of ladyginoside considered as its active ingredient on the adenohypophysis was studied. According to the results of experiments on rabbits, a probable mechanism of action of ladylginoside mediated through adenohypophysis was established in the fact of the existence of "pituitary-thyroid" system. On the other hand, the prosthetic part of the triterpene glycosides is confirmed as an effector of these substances.
