This article analyzes the processes of delimitation and demarcation of the borders of two Central Asian countries, namely the Republic of Uzbekistan and Kazakhstan. It also considers the completion of joint procedures for the final stage of demarcation works, which were resolved over many years. The establishment of state borders between these two countries is conditioned by adherence to the principles of international law, such as the principle of territorial integrity of borders, non-interference in internal affairs, which in turn contribute to the comprehensive development of bilateral relations between these countries.