ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
197
ENDOTHELIAL FUNCTION ASSESSMENT IN PREECLAMPTIC
PREGNANCIES WITH INFLAMMATORY PERIODONTAL
CONDITIONS
Shukrullaeva G.J.
Basic Doctoral Student,
Department of Orthopedic Dentistry and Orthodontics,
Bukhara State Medical Institute
Ahmedov A.B.
Assistant,
Department of Orthopedic Dentistry and
Orthodontics,Bukhara State Medical Institute
https://doi.org/10.5281/zenodo.15880324
Relevance of the Study.
According to modern perspectives, preeclampsia
(PE) is a pregnancy-induced hypertensive condition characterized by damage to
organs such as the kidneys, liver, and the hemostatic system, as well as
neurological symptoms and fetal distress [2,4]. Many authors note that
moderate to severe forms of PE are increasingly prevalent. These forms can lead
to fetal complications and multi-organ failure in the mother. This underscores
the need to predict and prevent the development of complications in other
organs and tissues, including periodontal tissues, in cases of PE [1,3].
Aim of the Study.
To assess the status of endothelial dysfunction in
pregnant women with inflammatory periodontal diseases who are diagnosed
with preeclampsia.
Materials and Methods.
A total of 120 pregnant women aged 18 to 49
years were examined using clinical, functional, and laboratory methods. The
participants were divided into three groups:
Main group
: 60 pregnant women with diagnosed preeclampsia.
Comparison group
: 40 pregnant women with no signs of preeclampsia
(physiological pregnancy).
Control group
: 20 non-pregnant women of reproductive age.
Results.
In the main group, the incidence of moderate and severe
periodontitis was found to be 2.3 and 5.66 times higher, respectively, compared
to the group with physiological pregnancies. This suggests that vascular wall
changes are occurring, reflected by a reduction in the anticoagulant and
fibrinolytic activity of the endothelium. Altered thromboresistance in the
endothelial lining is considered a key factor contributing to the progression of
periodontal inflammation.
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
198
In patients from the main group, decreased anticoagulant activity was
linked to reduced secretion of antithrombin III by the endothelium. Significant
differences were observed between groups in terms of antithrombin III levels
before and after cuff testing. In the control group, the values were 97.61±5.9%
and 124.32±8.62%, respectively. In the comparison group, the levels dropped to
91.43±5.31% and 112.32±6.4%, indicating normal physiological changes during
pregnancy. However, in the main group, these values were significantly lower at
74.51±4.06% and 88.12±4.54% (p<0.05).
Based on these indicators, an index for endothelial anticoagulant activity
was calculated to assess vascular condition, which resulted in 1.28±0.08 for the
control group, 1.23±0.06 for the comparison group, and 1.18±0.09 for the main
group. This statistically significant decrease in the main group highlights
impaired endothelial function.
Conclusion.
The findings indicate that pregnant women with PE
demonstrate reduced hypocoagulant activity, implying the presence of
pathological conditions such as hypercoagulation and endothelial dysfunction.
Furthermore, increased Hageman factor-dependent fibrinolysis time and
reduced endothelial fibrinolytic activity suggest a higher risk of vascular
thrombosis. These systemic changes may be sufficient to cause localized chronic
inflammation in the periodontal tissues. Elevated levels of homocysteine and
endothelin-1 are potential indicators of serous inflammation and clinical
symptoms in the periodontal tissues of these patients.
References:
1.
Sibai B.M., Stella C.L. (2009). Diagnosis and management of atypical
preeclampsia-eclampsia. American Journal of Obstetrics and Gynecology,
200(5): 481.e1–481.e7.
2.
Van Winkelen P., Van der Velden U. (2002). The role of inflammation in the
pathogenesis of preeclampsia and periodontal disease: a common link? Journal
of Clinical Periodontology, 29(9): 768–777.
3.
Konopka T., Paradowska-Stolarz A. (2012). Periodontal diseases and
systemic diseases: Pre-eclampsia and other pregnancy complications. Archives
of Medical Science, 8(4): 691–697.
4.
Redman C.W.G., Sargent I.L. (2005). Latest advances in understanding
preeclampsia. Science, 308(5728): 1592–1594.
