ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
134
GUT MICROBIOTA AND HUMAN HEALTH
Gulchekhra Otabek qizi Otabekova
Ozodjon Ilkhomovich Ergashov
Student of the Tashkent International Kimyo University, Scientific Secretary of
the Tashkent Scientific Research Institute of Vaccines and Serums,
https://doi.org/10.5281/zenodo.16963687
Relevance.
In recent years, scientific research has shown that the intestinal
microflora (beneficial microorganisms in the intestine) is associated with the
immune system, mental health, metabolic disorders (e.g., obesity, diabetes),
cardiovascular diseases, and even brain function [1, 2]. Currently, numerous
clinical studies conducted around the world prove a close relationship between
specific types of microbes and human health, which causes eubiosis, and various
diseases. That is why the connection between the intestinal microflora and
human health is considered very relevant today [3,4].
The purpose of the study.
The study of the effect of the composition and
diversity of the intestinal microbiota on human health.
Research materials and methods.
The study was conducted at the clinic
of the Tashkent International University of Chemistry. The methods of
retrograde analysis, bacteriological analysis, metagenomic, metabolomic,
bioinformatic analysis, and metotranscriptomy were studied for the study.
These analysis methods focus on the 16S ribosomal RNA gene, which is highly
conserved among bacteria and allows species identification and phylogenetic
analysis. Also, analyzing the composition of DNA, analyzing the composition and
functions of the intestinal microbiota, sequencing RNA, determine the functional
capabilities of microorganisms, which genes are actively expressed.
Results and analyses.
These studies explore the relationship between the
composition of the gut microbiota and human health on a population basis to
provide insight into how various diseases characteristic of microbiota disorders
develop. Studies have shown a close relationship between the composition of
the intestinal microbiota and the functioning of the immune system, as well as
the role of the normal microbiota in preventing various infectious and somatic
diseases. Different levels of intestinal microbiota disorders (dysbiosis) also have
a strong effect on metabolism, leading to several chronic diseases, including type
2 diabetes, hepatosis, various types of allergies, and even neurological disorders
such as depression. In a number of experiments, it has been found that the
preventive use of probiotics and prebiotics has a positive effect on the
composition of the intestinal microbiota and, thus, improves overall health.
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
135
According to recent studies, it is confirmed that the gut microbiota can influence
mental and emotional health through neurochemical signaling.
Conclusion.
The gut microbiota is an integral part of human health. Its
composition and functional state affect the functioning of the whole organism.
An imbalance of the microbiota can be a major factor in the development of
various diseases. Therefore, maintaining the normal state of the intestinal
microbiota is essential for the health of the entire div.
References:
1.
Afzaal M, Saeed F, Shah YA, Hussain M, Rabail R, Socol CT, Hassoun A,
Pateiro M, Lorenzo JM, Rusu AV, Aadil RM. Human gut microbiota in health and
disease: Unveiling the relationship. Front Microbiol. 2022;13:999001. doi:
10.3389/fmicb.2022.999001.
2.
Yodgorova N. T., Fayzullaeva Z. R., Sh M. F. Changes in the intestinal
microflora in the baby and the ways of their correction //World Bulletin of
Public Health. – 2022. – Т. 17. – С. 37-41.
3.
Gadoeva O. et al. New efficiencies of energy-saving facade paints based on
a combined film-forming agent //Journal of Physics: Conference Series. – IOP
Publishing, 2022. – Т. 2388. – №. 1. – С. 012136.
4.
ZR Fayzullaeva, L Sh Eshbekova. Modern methods of checking the
characteristics of oncoviruses. Journal of healthcare and life-science research.
2023/12/16, 2(12), 132-136.
