ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
112
DEVELOPMENT OF CARDIORENAL SYNDROME IN PATIENTS WITH
ARTERIAL HYPERTENSION
Rakhimova Gulsum Pulatbaevna
Tashkent Medical Academy, Tashkent, Uzbekistan
https://doi.org/10.5281/zenodo.14162081
Introduction:
Arterial hypertension (AH) is one of the most common
diseases. It is a major risk factor for myocardial infarction, acute cerebral
circulatory failure, heart failure and mortality.
Purpose:
To evaluate the features of cardiorenal syndrome in women
with arterial hypertension.
Material and Methods:
A study of 65 women (mean age 52 years) with
AH was conducted. Patients were divided into 2 groups according to div mass
index (BMI). Group 1 consisted of 30 patients with AH and BMI up to 27 kg/m2,
group 2 - 35 patients with AH and obesity (BMI ≥ 30 kg/m2, volume to waist
ratio >0.8). All patients underwent general chemical methods of examination.
daily monitoring of blood pressure (BP), ECHO CG, renal functional status by
determination of creatinine, glomerular filtration rate (GFR) according to MDRD
equation, daily urinary excretion of albumin (MAU).
Results:
Differences in blood pressure variability (BPV), time index (TI)
were revealed in all examined patients. The level of VAD increased significantly
in both groups, but in group 2 of obese women it was 1.5 times higher, and the
TI increased more during the night time 1.8 times in group 1 and 2.5 times in
group 2. Diastolic dysfunction of the left ventricle, increased left ventricular
myocardial mass index (LVMI) by 1.5 times and 1.6 times, respectively.
Concentric LV hypertrophy was detected in 44.2% of group1 patients and 55.8%
of obese AH women, eccentric LV hypertrophy in 10.3% and 12.1% of patients,
respectively. Mean serum creatinine values did not differ significantly between
them, but the percentage of patients with elevated creatinine was higher in
group2 (2.8% and 9.7%, respectively). In parallel, in obese AH patients, the
number of patients with SCF < 70 ml/min/1.73m3 increased from 4.0% in group
1 to 10.4% in group 2, with an increase in glomerular filtration from 87.3
ml/min/1.73m2 to 97.2 ml/min/1.73m2, which is probably due to increased
renal blood flow. A high percentage of MAU was found in women with AH. Thus,
it was 27.2% in obese patients and 11.0% in non-obese women; the level of daily
albumin increased in group 1 to 46.84 mg/l and in group 2 to 61.23 mg/l.
Increased MAU in women becomes a predictor of arterial hypertension with the
development of renal failure, which is more significant in the presence of obesity
and is a marker of early renal vascular dysfunction with the subsequent
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
113
development of chronic kidney disease. Correlation analysis of the magnitude
and rate of morning rise of CAD and DA in women with AH revealed a
correlation between IV DA and MAU, reflecting the state of intraclubular
haemodynamics. With the development of obesity, a correlation between the
functional state of the kidneys and the diastolic function of the heart was found.
Conclusion:
Thus, in women with AH, careful investigation of the structural and
functional status of the kidneys should be performed, especially in the presence
of obesity.
