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MORPHOLOGICAL CHANGES OF THE KIDNEY IN BREAST CANCER
Khodjieva Nozima Shukhratovna
Bukhara Medical Institute named after Abu Ali ibn Sino
https://doi.org/10.5281/zenodo.14060080
Relevance.
The increase in the number of oncological diseases over the
past decades requires the development of new drugs and methods of influencing
tumor cells, in some cases, the intensification of chemotherapy regimens [1-2].
Along with the successes achieved in the treatment of tumor diseases, the
toxicity of the treatment is quite a big problem. Kidney damage developing in
cancer patients can lead to a change or increase in the concentration of drugs,
thereby increasing their toxicity, prolonging the duration of hospitalization and
increasing mortality [3].
The spectrum of kidney damage in tumor diseases is quite wide and can be
caused both directly by tumor infiltration and damage to renal tissue by
metabolites of tumor cells, glomerular lesion, and the nephrotoxic effect of
drugs, radiation therapy. In addition, the risks associated with complications
after bone marrow transplantation, infections due to immunosuppression
(including sepsis), and tumor lysis syndrome should be taken into account [4].
Paclitaxel chemotherapeutic drugs are inhibitors of mitosis, block cell division,
disrupt the function of microtubules and some enzyme proteins, as well as alter
the metabolism of amino acids and some other substances, such as nucleic acids,
lipid synthesis, and affect cellular respiration [2].
The aim of the work is to study the morphological and
immunohistochemical characteristics of the kidney in breast cancer.
Materials and methods of research.
The experiment was performed on
20 white female rats at the age of 3 months. All procedures for keeping rats and
removing them from the experiment were carried out according to the rules of
work using experimental animals.
As part of the work, experimental evidence of changes in kidney morphology
was obtained. In breast cancer, a decrease in kidney mass and volume was
observed in experimental animals subjected to chemotherapy, with the most
informative indicators being the total area of the renal corpuscles, the area of
the vascular tangle, the diameter of the proximal and distal convoluted tubules
and their cavities. When comparing the parameters of the renal corpuscles of
rats of the experimental groups with those of the control group after
chemotherapy, the largest decrease in size was observed in rats of group 4 - by
1.81 times, and in the remaining groups - by 1.85 times.
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
194
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