ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
42
FUNCTIONAL STATE OF THE KIDNEYS IN PATIENTS WITH
UROLITHIASIS IN THE ELDERLY
Akilov Farhad Ataullayevich
Navruzov Elbek Ravshanovich
Tashkent Medical Academy, Republic of Uzbekistan, Tashkent city
https://doi.org/10.5281/zenodo.14799370
Annotation:
One of the most common formsчеof chronic progressive
nephropathy leading to the developmentof chronic renal insufficiency, along with
atherosclerotic lesions and diabetic microangiopathy, ischronicpyelonephritis, the
background for the development ofwhich is often a urinarytractobstruction with a
concretion
Key words:
urolithiasis, markers of nephrofibrosis, renal function,
tubulointerstitial changes.
Accordingto modern concepts, age-related changes in the kidney are
characterized by loss of renal mass, arterial sclerosis, hyalinosis of arterioles, an
increase in the number of sclerotic glomeruli, loss of tubules, and
interstitialfibrosis. Currently, it is believed that the decreasein renal function is
more closely correlatedлируют with tubulointerstitialchanges,the indicator of
which is β2-microglobulin (β2-MG)
MATERIALS AND METHODS
110 patients with nephrolithiasis were
examinedand treated at the Urology clinic of theTMA Clinical Hospital.
Patients with acute pyelonephritis, complete obstruction of the urinary tract,
accompanied by impairedrenalfunction and hydronephrotic transformation,
patients withacute and end-stage renal insufficiency, patients with severe
concomitant pathology and severe obesity were excluded from the study.
The high prevalenceof persistent GFR reduction and the poor overall
prognosis characteristic of older patients determine the need for early detection
and, if possible, prevention of the development of CRF. Measurement of the
concentrations of a number of cell response mediators, including the main
нефрофибрmarkers of nephrofibrilli, along with the useof traditional methods
allows for a more detailed assessment of existing renal damageние
When analyzingthe results obtained, it was found that the concentration of
IGF-1 does not undergo significant changes depending on creatinine clearance
and GFR. At the same time, the concentration of IGF-1 in the older age group was
not significantlylower than in Group 2 patients, which may reflect lower
reparativeные capabilities in older patients.
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
43
The study does not confirm a significant increase in the activation of
nephrofibrosisa processes in patients with ICD of the older agegroup compared to
middle-aged patients. Probably, this trend is due to the peculiarities of the course
of the pathological processa in ICD, associated witha predominant lesion of the
tubulointerstitial apparatus. As a result of repeated relapses of ICD in middle-aged
patients, persistent and irreversible changes in the renal parenchyma also
occur,leading to the development oftubulointerstitial fibrosis.
The decrease in the functional capacity of the kidneys in patientswith ICD of
the older agegroup is due to both tubulointerstitial changes on the background
of nephrolithiasis, and involutionaland changes in the interstitium andclub
capillaries.
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