ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
82
THE EFFICACY OF PULSED THERAPY IN THE MANAGEMENT OF
SYSTEMIC SCLERODERMA: A STATISTICAL ANALYSIS
Nabiyeva A.X.
Scientific seeker:
Bekenova G T.
Scientific leader: tfn dotsent
Tolipov O‘.U.
Master:
TMA Department: faculty and hospital therapy
№1occupational pathology
https://doi.org/10.5281/zenodo.14887175
Keywords:
systemic scleroderma, pulsed therapy, corticosteroids,
immunosuppressive agents, statistical analysis.
Abstract:
Systemic scleroderma is a rare autoimmune disorder that affects connective
tissues and blood vessels, leading to skin thickening, organ damage, and other
complications. While there is no cure for this disease, various treatment options
are available to manage its symptoms and slow down its progression. One such
treatment modality is pulsed therapy, which involves the administration of high-
dose corticosteroids or immunosuppressive agents in short intervals. However,
the effectiveness of pulsed therapy in systemic scleroderma remains
controversial, with limited studies providing conflicting results.
This dissertation aims to investigate the efficacy of pulsed therapy in the
management of systemic scleroderma through a statistical analysis of available
data. A systematic review of literature will be conducted to identify relevant
studies that have evaluated the use of pulsed therapy in systemic scleroderma
patients. The selected studies will be assessed for their quality and risk of bias
using established criteria. Data extraction will be performed to obtain
information on study design, patient characteristics, intervention details,
outcome measures, and adverse events.
The collected data will be analyzed using appropriate statistical methods to
determine the overall effect size of pulsed therapy on various outcomes, such as
skin thickness, lung function, and quality of life. Subgroup analyses will be
conducted based on factors such as treatment regimen, disease severity, and
duration of follow-up. Sensitivity analyses will also be performed to assess the
robustness of the findings and potential sources of heterogeneity.
The results of this dissertation will provide a comprehensive overview of
the current evidence on the efficacy of pulsed therapy in systemic scleroderma
ACADEMIC RESEARCH IN MODERN SCIENCE
International scientific-online conference
83
and inform clinical decision-making regarding its use. The findings may also
highlight areas for future research and contribute to the development of more
personalized treatment approaches for this complex disease.
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