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CHRONIC RENAL DISEASE IN PATIENTS WITH CHRONIC
OBSTRUCTIVE LUNG DISEASE
Sharipova N.S.
Jabborov O.O.
Tashkent medical academy
https://doi.org/10.5281/zenodo.15362866
Background:
The incidence and prevalence of chronic kidney disease
(CKD) continue to rise worldwide. Increasing age, diabetes, hypertension, and
cigarette smoking are well-recognized risk factors for CKD. Chronic obstructive
pulmonary disease (COPD) is characterized by chronic airway inflammation
leading to airway obstruction and parenchymal lung destruction. Due to some of
the common pathogenic mechanisms, COPD has been associated with increased
prevalence of CKD.
Purpose of the work:
to study the frequency of chronic kidney disease
(CKD) occurrence in patients with chronic obstructive pulmonary disease
(COPD).
Materials and methods:
A retrospective study of 65 medical histories of
patients with COPD stages II-IV without a previously established diagnosis of
kidney disease and diabetes mellitus was conducted. All patients were male,
with an average age of 59.93±8.58 years and an average duration of COPD of
7.05±4.04 years. The glomerular filtration rate (GFR) was calculated using the
Cocroft-Golt, MDRD, CKD-EPI formulas.
Results.
The criterion for decreasing kidney function is the level of
glomerular filtration rate, standardized to the div surface, which is below
normal values, i.e., below 90 ml/min/1.73 m2. CFT within 60-89 ml/min/1.73
m2 is considered an initial or slight decrease. If the GFR is below 60
ml/min/1.73 m2, the presence of CKD is established even in the absence of any
markers of kidney damage.
When calculating Golt's CKF ≥ 90 ml/min, it was found in 15 people (23%),
CKF 60-89 ml/min - in 48 (74%), CKF <60 ml/min - in 2 patients (3%).
When calculating eGFR according to CKD-EPI ≥ 90 ml/min, it was found in
19 people (29%), eGFR 60-89 ml/min - in 44 (68%) patients, eGFR <60 ml/min -
in 2 patients (3%).
When calculating eGFR according to MDRD ≥ 90 ml/min, it was detected in
19 people (29%), eGFR 60-89 ml/min - in 45 (69%), eGFR <60 ml/min - in 1
patient (2%).
When conducting a correlation analysis, a correlation between CKD and the
age of patients was revealed, with the highest age-relatedness demonstrated by
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187
CKD according to Cockcroft-Golt (r=-0.61, p<0.001), and the lowest - CKD
according to MDRD (r=-0.27, p<0.05). A correlation was also established
between eGFR and div mass index (p<0.01), and the presence of arterial
hypertension.
Conclusion.
When determining CFT using the main "calculation" methods,
no significant differences were found in the obtained results. In 68-74% of
patients (depending on the calculation method), the II stage of CKD was
identified, in 2-3% - the III stage of CKD.
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