ACADEMIC RESEARCH IN MODERN SCIENCE
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IMPORTANCE OF MEDICINAL PLANTS IN THE TREATMENT OF
ACNE VULGARIS
Sagdullayeva B.O.
Institute of Pharmaceutical Education and Research, Assistant of the
Department of Medical and Biological Sciences, PhD
Mahamadjonov K.
Institute of Pharmaceutical Education and Research,
Student of group 21 IP-2
https://doi.org/10.5281/zenodo.13334954
Annotation.
Acne is a skin condition associated with the activation of the
sebaceous glands, enlarged and blocked sebaceous glands. Where the sebaceous
gland on the skin is blocked, bacteria begin to multiply. Bacteria cause
inflammation and swelling in this area. Acne vulgaris is the most common
inflammatory, chronic, recurrent disease of the sebaceous follicular apparatus
localized on the face, back, and various parts of the div. Varying degrees of
acne occur in 80-85% of people between the ages of 12 and 25 and in 11% of
people over the age of 25.
Key words.
Acne vulgaris, Propionibacterium acnes, Staphylococcus
epidermidis, skin diseases, medicinal plants.
Purpose.
To study the medicinal plants that can be used in the treatment
of acne vulgarisbased on literaturdata.
The results.
Acne vulgaris is one of the most common dermatological
diseases in the world among skin diseases [1; 5]. It usually occurs in almost
everyone during a person's life. The pathogenesis of acne is complex and
depends on the following four main factors: increased activity of the sebaceous
glands
under
the
influence
of
androgen
hormones,
follicular
hyperkeratinization, colonization of the bacterium Propionibacterium acnes (an
anaerobic bacterium that is a normal component of the skin microflora), and
inflammation [6]. Due to the effect of androgen hormones, the high amount of oil
produced by the sebaceous glands leads to the proliferation of the bacterium
Propionibacterium acnes in the ducts of the skin glands, and this proliferation
produces anti-inflammatory cytokines, interleukin-1b (IL-1b), IL-8, induces the
production of granulocyte-macrophage colony-stimulating factor (GM-CSF),
tumor necrosis factor α (TNF-α), and complement. In addition to
Propionibacterium acnes bacteria, Pityrosporum ovale and Staphylococcus
epidermidis are also present in acne as the main causative microorganisms.
There are 3 types of acne: comedonal, nodular and papulopustular. Comedonal
type acne shrinks without inflammation, while nodular and papulopustular acne
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shrinks with inflammation [2]. A variety of medications are available to treat
acne vulgaris, including antibiotics, retinoids, and hormonal therapy.
The use of natural medicines, especially plants, began thousands of years ago.
In the last decade, there has been an increasing interest in medicinal plants due
to their increasing resistance to existing antimicrobial agents, side effects and
sometimes high cost of treatment. Abies koreana essential oil has a strong
antibacterial effect against drug-sensitive and resistant Propionibacterium acnes
and Staphylococcus epidermidis. In addition, Abies koreana essential oil reduces
the lipopolysaccharide-induced secretion of TNF-α, IL-1β, IL-6, nitric oxide (NO)
and prostaglandin E2 (PGE2), suggesting the anti-inflammatory effects of Abies
koreana essential oil. shows [7]. Some Indian medicinal plants such as Ammonia
baccifera, Hibiscus syriacus, Quercus infectoria, Berberis aristata, Couroupita
guianensis, Symplocos racemosa and Mucuna pruriens have excellent
antibacterial inhibitory effects. In addition, the ethanol extract of Symplocos
racemosa has the highest activity due to the presence of antibacterial alkaloids.
Hemidesmus indicus, Coscinium fenestratum, Tephrosia purpurea, Euphorbia
hirta, Symplocos racemosa, Curcubito pepo and Eclipta alba have been found to
have a strong inhibitory effect against Propionibacterium acne [3; 4].
Conclusion.
The studied literature showed that acne of various degrees occurs
in 80-85% of people aged 12 to 25 years and that one of the main causes of the
disease is microorganisms. Medicinal herbs such as Abies koreana essential oil,
Ammonia baccifera, Hibiscus syriacus, Quercus infectoria, Berberis aristata,
Couroupita guianensis, Symplocos racemosa, Mucuna pruriens, Hemidesmus
indicus, Coscinium fenestratum, Tephrosia purpurea, Euphorbia hirta, Curcubito
pepo and Eclipta alba are used to treat acne vulgaris. plants were found to be
effective.
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