No. 1 (2004)

Subject of the inquiry: 148 patients with degenerative dystrophic diseases of the hip joint, of them 103 with osteoarthritis and 45 with avascular necrosis of the femoral head.
Aim of the inquiry: improvement of the diagnosis of degenerative-dystrophic diseases of the hip using possibilities of ultrasonography and magnetic resonance imaging.
Methods of research: X-ray, ultrasonography and magnetic resonance imaging.
The results achieved and their novelty: For the first time, the role of ultrasonog-aphy and magnetic resonance imaging in osteoarthritis and avascular necrosis of the hip was established in comparison with conventional X-ray. The result have shown that sensitivity of ultrasonography in osteoarthritis was low (57.7%) in the detection of femoral head deformation. In avascular necrosis of the hip detection of femoral head deformation was revealed better - 89.7%, which can be explained by differences in the mechanism and localization of deformation in these diseases. Ultrasonography was quite sensitive to changes of the joint capsule both in osteoarthritis and avascular necrosis, the sensitivity 86.0% and 84.6% respectively. MRI was superior to X-ray in the assessment of space orientation of the joint surfaces, necrosis zone, synovitis, subchondral cysts, structural changes and joint effusion. X-ray was more preferable for the detection of ostephytosis, subchondral sclerosis and changes of the joint space in osteoarthritis.
Practical value: of the work consisted in the concretization of sonographic and MRI signs of degenerative dystrophic diseases of the hip joint and in the suggested algorithm of using radiological methods for establishing the nature of hip joint pathology.
Degree of inculcate: the results of research were introduced in the Radiology Department of First Tashkent Medical Institute and the Department of Large Joint Pathology Department of the Traumatology and Orthopedy Research Institute.
Sphere of usage: radiology, traumatology and orthopedy, rheumatology.

Subject of the inquiry: 298 patients with finn deformations of the larynx and trachea
Aim of the inquiry: early rehabilitation of patients with firm deformations of the larynx and trachea path optimization and creating clinical and pathogenic methods of complex treatment.
Methods of the inquiry: clinical examination, special examination: LOR-examination, endoscopy of air ways, X-ray, CT, MRI of larynx, trachea and bronchus, bacterial examination of larynx and trachea wounds; morphological examination, biochemical methods of examination: lipid peroxidation, antioxidant enzymes, activity of hepatic monooxygenase system (MOS); biophysical methods of examination: исследование electric damage of erythrocytes’ membrane (EDEM), blood viscosity (BV) and blood shift velocity (BSV); cytological examination.
The results achieved and their novelty: In patients with firm deformations of the larynx and trachea, firstly basing on complex investigation clinical and structural-functional parameters revealed pathomorphological changes in neck tissues as chronic inflammation with productive component. Despite, revealed disrupt balance of process lipid peroxidation and antioxidant system, hydroxylic function of liver, decrease of electoral penetrability of erythrocytes’ membrane and aggravate of hemorheology. With this, level of expression of changes depends on clinic form and load disease, correlate with stage of wound healing and after restore of functions of the larynx and trachea gradually becoming normal. Presented classification of the firm deformations of the larynx and trachea, permitting complexly counting etiologic factor and morphological variant of the damage of laryngotracheal tract. In scheme of the pathogenic complex conservative therapy before and after reconstructive operations included medicine, influencing on Hemodynamic, with ability membranotrope action, systemic enzymotherapy, immunostimulators, and correction of the tissue metabolism by laser. Created private and modified methods of reconstructive laryngotracheoplasty in case of cicatricle stenosis of glottic and subglottic parts, bilateral paralyses of the larynx, cicatricle deformations of pharyngolarynx, combination deformations and defects of the larynx and trachea, permitting single stage restore laryngotracheal ways.
Practical value: The investigation of pathogenic mechanism of developing of the firm deformations of the larynx and trachea on data of changes of main functional and metabolic processes will permit not only activating and improving of pathogenic therapy, and forecasting variant of development and course of postoperative period after reconstructive operations.
Use of proposed methods of complex conservative and surgical treatment of the firm deformations of the larynx and trachea allowed to provide whole volume of restoring means in more short time and with less quantity of stage operations, preoperative preparing till 3 days, hospital stay till 14-20 days, surgical operations in 1.9 time.
Degree of embed and economical effectivity: The results of investigation intruded in treatment practice of the First and Second Tashkent Medical Institutes, LOR-clinics of Samarqand territorial children hospital, territorial hospital of Karshi. Materials of the investigation using in study process of LOR - cathedra First Tashkent Medical Institutes during lectures and practice tutorials with students, magistracies, and clinic ordinators. Determined main economic effect in use of proposed complex therapy in connection with reduce of term of treatment and hospital stay (on an average 10 days) and taking off or decreased disability on 67% patients.
Sphere of usage: otorhinolaryngology, surgery, reanimation

Subject of the inquiry: 120 patients with inflammatory diseases of the maxillary sinuses (177 affected sinuses).
Aim of the inquiry: improve the diagnosis of inflammatory diseases of maxillary sinus diseases using B-modc ultrasonography
Methods of research: Ultrasonogrpahy, X-ray, magnetic resonance imaging.
The results achieved and their novelty: Based on the results of investigation of 120 patients with inflammatory diseases of the maxillary sinuses (177 affected sinuses) the following was found: in acute sinusitis (irrespective of the form) ultrasonography had quite low specificity - 50.0+6.7%. However the sensitivity of the method in catarrhal and purulent forms of acute sinusitis came to 75.0+11.6% and 93.0+3.9% respectively. In all the forms of chronic sinusitis the parameters indicated good informativeness of B-modc ultrasonography: hyperplastic - sensitivity 82.0+5.2%, specificity 95.0+3.0%; purulent - sensitivity 88.0+6.8%, specificity 79.0+8.5%; cysts and polyps - sensitivity 87.0+5.0%, specificity 93.0+3.8%. The research demonstrated possibilities of ultrasonography in the diagnosis of inflammatory diseases of the maxillary sinuses. Diagnostic value of B-modc ultrasonograhy was shown in different forms of maxillary sinusitis. Practically convenient interpretation technique of maxillary sonograms and protocol of examination were developed. Sonographic criteria were defined for differential diagnosis of different inflammatory diseases of the maxillary sinuses as well as the role of B-modc ultrasonography in the algorhithm of radiological investigation of the maxillary sinuses.
Practical value: improvement of maxillary sinusitis, decrease of patient’s exposure to radiation (unjustified use of X-ray in the absence of pathology), avoiding of invasive methods (diagnostic puncture in case of mucosal hyperplasia of cysts) Degree of inculcate: The results of the investigation were introduced in the Otorhynolaryngology and Radiology departments of the 1-st Tashkent Medical Institute Sphere of usage: radiology, otorhynolaryngology.

Dcdagigical driccss if the mathematician cducatiin in cillcges, in cinditiin if market ecinimics and derfirming the secind stage if the natiinal drigram in dredaring the frames.
Aim if the inquiry': Devclid didactic and methidieal bases intcrciudling and rcccivcrshid if the structure if the mathematical cducatiin in cillcges in cinditiin if the unceasing educatiin.
Methid if inquiry: Methid if the study served directive dicumcnts if the Rcdublics if Uzbckistan-“Educatiin Law”, “Natiinal drigram in dredaring the frames”, dicumcnts in dredaratiin yiunger sdecialists in drifessiinal cilieges. In dricess if the functiining is used driblcm-silving methid educatiin with drivisiin fir rcalizatiin intersubject rclatiin and drifessiinal directivity.
The results achieved and their nivelty:
1. Hierarchical structure if the cducatiin mathematician in cinnectiin with drifessiinal subject is studied, methidieal bases if the shading the main mathematical skills and skill in rcalizatiin if the drifessiinal directivity are determined.
2. The theiretical and dractical laws intcrciudling and receivershid mathematicians with drifessiinal-technical cycles if the sciences, drividing drifessiinal directivity if mathematical dredaratiin are mitivated.
3. The cillcctiin if the main firms, methids and facilities if the shading and devclidmcnts ti drifessiinal directivity if the educatiin mathematician, fiunded in intcrsubject rclatiin are revealed.
Dractical value: Elabiratcd mcthids if teaching can be used at dcvclidmcnt if the curriculums and drigrams, as well as textbiik, schilastic alliwance in mathematician fiunded in cducatiin with drivisiin fir intersubject rclatiin and drifessiinal directivity.
Degree if embed and ecinimical affectivity: Elabiratcd mcthids arc intriduccd in driccss if the cducatiin mathematician in cillcges.
Sdhere if usage: Sccindary sdccial cducatiin.

Objects of research: tropical and subtropical plants in the closed soils of the Fergana valley.
Purpose of work: the study of tacsonomic an accessory of a genephond of tropical and subtropical plants of the Fergana valley.
Methods of research: the regular review, title of families is given by academy A.L.Takhtadjyan (1987). For definition a species composition and the descriptions of plants utilised regional floras: Flora Indica (1874), Flora of tropical Africa (1906), Flora Malesiana (1964), W. Haage (1983), C.Bacebcrg (1976), S.G.Saakova (1983), Adornment plants of the open and closed soil (1985). For specification of the forms, types used the checklists Florensis (2001), Torsanlorcnso (2002), Flower counsil of Holland (2000: 2001: 2002: 2003: 2004). At definition of life forms used system I.G.Sercbyakova (1962), and recommendations of E.S.Smirnova (1980): a phenology conducted by methodology LN.Bcydcman (1960); to the botany-geographical characteristic of studied plants were guided by the schema by S. M. Rasumovsky (1980): an assessment of the successfulness of the introductions of N.M. Carmishina (2003).
Novelty of work: for the first time on a scientific basis the genephone of tropical and subtropical plants of the Fergana valley were investigated. In a findings of investigation 454 species belonging to 70 families, 45 tribes arc revealed, to 224 types and their regular belonging is defined.
Practical value: the results of scientific research can be utilized for scientific work, textbooks and manuals.
Sphere of usage: scientific organizations, schools, lyccums, colleges, high schools and fans - gardeners.

Subject of the inquiry: 116 patients with rheumatoid arthritis of the hand joints and 25 healthy subjects.
Aim of the inquiry: improvement of the diagnosis of rheumatoid arthritis of the hand joints using sonography and magnetic resonance imaging.
Methods of inquiry: X-ray, sonography, magnetic resonance imaging and magnetic resonance imaging with contrast enhancement.
The results achieved and their novelty: For the first time data were presented on the role of sonography, magnetic resonance imaging and magnetic resonance imaging with contrast enhancement in the diagnosis of rheumatoid arthritis of the hand joints. The findings have shown that sonography in hand joint rheumatoid arthritis allowed detection of changes in soft tissues, synovial capsule, joint surfaces and ligaments. Diagnostic value was given of sonography in revealing characteristic sonographic signs of rheumatoid arthritis. Magnetic resonance imaging was highly informative radiological method to detect synovitis, changes of synovial capsule and subchondral cysts. Magnetic resonance imaging with contrast enhancement reliably detected the degree of activity and severity of the rheumatoid process.
Practical value: consisted in revealing and describing characteristic sonographic and MR1 signs of hand joint rheumatoid arthritis and in the developed radiological algorithm of the disease.
Degree of embed: the results of the investigation were introduced in the practice of rheumatology and radiology departments of the First Tashkent Medical Institute, in teaching process of the Radiology Chair of the First Tashkent Medical Institute.
Sphere of usage: radiology, rheumatology, traumatology and orthopedics.

The research object: The pedagogical process which develops research skills in 7-9 years of secondary education pupils that is part of forming the continuous education system under the conditions Republic of Uzbekistan's transitions into market economy.
Aim of the work: Development of contents and Methods on forming pupils research skills in teaching algebra and geometry 7-9 years of secondary education.
Methods of the research: philosophical, psychological, pedagogical, methodological literature analysis and textbooks on the algebra and geometry; observation, conducting conversations, the opinion polls of tests, written and oral interrogations; conducting pedagogical experiment and checking its result by the methods of mathematical statistics.
Obtained results and their novelty: It is developed structure and content of basic materials on introducing the research skills of the students of 7-9 grades of the schools; is revealed nature and the dynamics of the process of the formation of research skills.
Practical significance: the developed procedure and recommendations is important to improvement of the systematic and organizational work of introducing the research skills students of 7-9 grades of the schools and also it can be used with the improvement of curricula, with the creation of methodology benefits and textbooks on the algebra and geometry.
Levels of adoption and the economic effectiveness: the developed procedure on introducing the research skills of students is inculcated in the lyceum № 2 for gifted students and to the secondary school by № 25, Ellikkalinskeyeo region Republic of Karakalpakstan, and also in the secondary schools of № 207, №265, № 83 of Tashkent city.
Sphere of usage: This procedure can be used on the lessons of algebra and geometry in the general education schools and in the Lyceums.

Subject of the inquiry: Banach - Kantorovich module, C*-algebras, measurable Banach bundles, non commutative Arens algebras , derivation.
Aim of the inquiry: the realization of C*-algebras over A0 as algebras of operators on a Hilbert - Kaplansky module and description of derivation of the algebras of locally measurable operators affiliated with von Neumann algebra and of its subalgebras.
Method of inquiry: In the work methods of measurable banach Bundles, of functional analysis, of theory operator algebras are used.
The results achieved and their novelty:
It is proved that any cyclically compact operator on a Banach - Kantorovich module can be represented as a measurable bundle of compact operators; it is proved that every V -Fredholm operator can be represented as a measurable bundle of Fredholm operators; it is proved that every C*-algebras over A0 is isometrically *-isomorphic to a closed subalgebra of the algebra of all A0-bounded A0-linear operators on a Hilbert - Kaplansky module; a general form of derivations of the algebras of locally measurable operators affiliated with a von Neumann algebra is given; a complete description of derivations on the non commutative Arens algebras associated with von Neumann algebra and faithful normal semi-finite trace is obtained.
Practical value: the work has a theoretical character.
Degree of embed and economic effectivity: Results and methods introduced in the work can be used in special courses on functional analysis and theory of operator algebras.
Sphere of usage: the measure theory, functional analysis, theory of operator algebras, mathematical physics.

Subjects of the inquiry: the budgets of the Republic of Karakalpakstan.
Aim of the inquiry: to determine local budgets development laws; to develop theoretical rules and scientific recommendations for profitable perfection, account parts of the local budgets in the Republic of Karakalpakstan and interbudget relations.
Method of inquiry: economic, mathematic, comparative, system analysis, graphical models.
The results achieved and their novelty: the functioning features of the local bodies budgets of authority in the Republic of Karakalpakstan in the market conditions are determined; the grouping of the local budgets incomes for fixed and regulating sources definition of the incomes is offered as they call it international practice; the new approach to consideration of the local budgets is offered from the point of view by using them in the state order - granting to the population the minimal set of the public services in education sphere, public service etc.; it is offered to use the normative approach to determine the state social standards; the means redistribution is recommended on the complex basis in the budget regulation methods; The recommendations for payments perfection for natural resources, in particular, are produced the expediency of payments collection for super limit emissions is proved at payments for pollution of a local budgets environment in the incomes; the attraction opportunities in additional incomes in the local budgets through the financial markets are determined.
Practical value: the results of research can be used in local bodies practical activity of authority at research for additional sources of formation the local budgets incomes; budget regulation system engineering within the budgets framework of local self-management; development of alignment mechanism on a socio economic development level of local administrative - territorial educations.
Degree of embed and economic effectivity: the research results and recommendation were used by the Finance Ministry of the Republic of Karakalpakstan by budget development of the Republic of Karakalpakstan in 2003.
Sphere of usage: the local budgets, at budget politics manufacture in the region, its financial tactics and strategy.

Objects of research: pancreas gland, liver, small intestine, blood of experimental rats with acute pancreatitis.
Purpose of research: studying dynamic of changes in essential trace elements content in different tissues, interplays between their contents and structural metabolic disturbances in pancreas gland, liver and small intestine for acute experimental pancreatitis.
Methods of research: neutron activation analysis, biomicroscopy, biochemical methods of studying enzymes’ activity, biophysical methods of studying rheologic features of blood, light microscopy of tissues.
Results obtained and their novelty: Development of acute pancreatitis was accompanied by reducing selenium content and, especially cobalt in blood plasma, liver and pancreas gland, increasing their content in small intestine in interstitial-edematous and parenchymatous (purulent-necrotic) period. Content of zinc, chromium and iron in small intestine and pancreas gland was decreasing, whereas they were wavy in blood serum and liver. There is a close correlation between selenium, zinc, chromium content and SOD, gluthathionc peroxidase activity in the mentioncd tissues. Level changes in the mentioned trace elements, microcirculation disturbances in the tissues studying and blood rheologic features, due to acute inflammation of glandular parenchyma on the one hand, and striking increasing its concentration on the other hand, and, therefore, aggression of protco- and hydrolytic enzymes of pancreas gland, determine uncontrolled LPO intensification. A close anatomic physiologic interrelation between pancreas gland and liver and small intestine causes development of structural changes in the mentioned organs for acute cryogen pancreatitis. Such pronounced hcmocirculation disorders as dilatation and blood formation in microvessels of exchange link revealed to be in earlier terms of experiments. These changes were rapidly enough transformed in extensive destructive and inflammatory changes of parenchymas of pancreas gland and liver. Desquamation areas in mucosal epithelium were revealed in small intestine in late terms of research.
Practical value of research: Results obtained expose importance of essential trace elements for development of structural functional disorders in pancreas gland for its acute inflammation. Establishcmcnt of trace lemcnts’ homeostasis disturbances in digestive organs and their involvement in pathologic process evidence a necessity to wotk out measurements aimed at correction of trace elements’ disbalance.
Inplcmcntation degree and economic effectiveness: Main statements of the thesis arc included into a course of lectures and practical lessons on the chairs of Normal & Pathologic Physiology of the 2nd TashMI.
Field of application: Medicine