Influence of radio frequency electromagnetic radiation on the cardiovascular system (clinical-experimental study)

The urgency and relevance of the theme of dissertation. Among the factors of the external electromagnetic radiation is invisible and is not perceived by the senses, not eye-catching factor standing on human health. Dangerous is the impact of radio frequency electromagnetic radiation (RF-EMR) on the body of people working under the impact of radiation, especially on the nervous and cardiovascular system (CVS), the organs of blood, endocrine, metabolic processes, and organs of digestion. With long-term occupational exposure revealed functional changes in the organs of 60% of those diseases SSA 60%, gastrointestinal disease in 40%.
It should be noted that the protection of public health from the effects of electromagnetic fields (EMF) is one of the serious problems. WHO is seriously concerned about the problem of protection of public health under conditions of EMF. Since 1994, the organization conducts a special program «WHO International EMF Project» (International Project WHO on electromagnetic fields). According to the WHO EMF under certain conditions can cause a change in behavior, the development of Parkinson's disease and Alzheimer's disease, memory loss, cancer and many other diseases.
At the same time, the evaluation of complex research to study the effect of different RF-EMR exposures on the immune and cardiovascular system (CVS), holding morphofunctional and biochemical tests on experimental animals and in people working in the factories pollution jobs this kind of radiation, development of clinical guidelines for the management of these patients in order to prevent the RF-EMR influence on the body arc topical issues of medical science and practice.
The available literature is not revealed details characterizing RF-EMR influence on the functional state of the vascular endothelium, indicators of immune system, coagulation factors, the state of cell metabolism et aL, contributes to the progression of CVD in individuals working in conditions of exposure to RF-EMR.
According to many researchers, chronic exposure to electromagnetic radiation (EMR) in vulnerable people develops multiple organ pathology. Studies of biological action of RF-EMR arc of great interest to scientists and the public. Publications in the media accurately reflect current trends in these studies.
This dissertation work is to organize high-quality implementation of the tasks set out in the Decree of the President of the Republic of Uzbekistan № U11-3923 dated 19.09.2007 «On main directions of further deepening reforms and implementing the State program of development of public health».
The aim of research work is to develop the tactics of the patients, the criteria for early diagnosis and prevention approaches violations of the cardiovascular system caused by electromagnetic radiation of radio frequencies in individuals occupationally exposed to direct and permanent effects of this radiation.
Scientific novelty of the research work is as follows:
developed a method for predicting the formation and progression of cardiovascular disease on people with occupational risk exposure to radio frequency electromagnetic radiation;
for the first time on experimental model evaluated the pathogenic mechanisms and depth cardio vascular system disorders, immune system and certain metabolic effects during radio frequency electromagnetic radiation exposure depending on different exposures and the radiation power;
for the first time proven the nature and severity of degenerative disorders of the cardio vascular system with the persons working under the direct and permanent radio frequency electromagnetic radiation exposure and the interrelation of these disorders with some clinical and instrumental and biochemical parameters;
improved integrative index based on a malondialdehyde over superoxide dismutase ratio, proved its high sensitivity and specificity and the possibility of use as a predictor of the development and progression of violations by the cardio vascular system under the influence radio frequency electromagnetic radiation.
CONCLUSION
1. In experimental animals under RF-EMR influence the morphological and functional CVS disorders develop from minor microcirculatory disorders, lung edema and myocardial hypertrophy, fiber pulping fibre muscle to severe violations of their own blood the heart, blood vessels perdiapedeza expressed structural abnormalities of the heart tissue, plasmorrhages appearance, stasis and aggregation of formed of blood, which increases with the power and duration of irradiation.
2. RF-EMR in experimental animals causes depression of cellular immunity and causes marked changes in carbohydrate and energy metabolism, the extent of which is limited by the power and duration of exposure, as well as the nature of the adaptive-adaptive processes and may determine destructive and degenerative processes in the body.
3. From the cardiovascular system in individuals with direct and constant RF-EMR exposure to develop expressed destructive and degenerative disorders in terms of ABL to TAG tissues of heart and blood vessels, the degree of which increases with the length of service under RF-EMR and arc not detected by routine clinical and instrumental CVS research methods.
4. RF-EMR impact on CVS in people with professional risk appears small manifestation of clinical and functional disorders in a variety of arrhythmias, and metabolic changes that do not reflect the true destructive and degenerative disorders by the CVS. As diagnostic tests should take into account the increase in the duration of the P wave, an increase of Makruz index, negative RV1, reduction EOS QRS, depression ST V5-6, QRS V5, the degree of change which correlates with the level of ABL to the TA, reflecting the severity of tissue destruction of the heart and blood vessels.
5. Persons working under the direct and constant RF-EMR exposure, work experience have a close relationship with the degree of activation of lipid peroxidation and antioxidant protection factor reduction, raising and lowering the index phospholipase deformation of red blood cells, increasing hyper-aggregation of platelets, which allows predicting the development and progression of multiple organ pathology, including CVS.
6. In individuals with direct and constant RF-EMR exposure is a significant inhibition of cellular immunity factors, progressive with increasing length of their work.
7. As the risk of violations of the CVS should use indicators such as the increase in part-time work under RF-EMR exposure more than 5 years, the growth of MDA and the degree of platelet aggregation, reduction in the rate of platelet aggregation, EDI and SOD, which with a high degree of confidence (P <0,01 - <0.001) correlated with the level of ABL to TAG infarction, reflecting the degree of destruction in it.
8. In persons with direct and constant RF-EMR exposure index TA heart tissue can be used as a method for early diagnosis of the CVS. Exceeding this figure is 5 or more times should be regarded as a diagnostic level, and to recommend to patients holding a routine treatment for the relief and prevention of progression