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GOUT AND ITS ASSOCIATION WITH BIOCHEMICAL MARKERS
Rakhmatov A.M.
Jabbarov O.O.
https://doi.org/10.5281/zenodo.14173037
Introduction:
Gout is a metabolic condition characterized by elevated
levels of uric acid, which forms crystals that affect the joints and can lead to
kidney damage. Gouty nephropathy, a serious complication, refers to kidney
impairment in individuals with chronic gout. This thesis examines the
relationship between gout, biochemical markers, and the development of gouty
nephropathy, particularly focusing on serum creatinine and uric acid levels.
Data:
1. Patients: A total of 46 patients diagnosed with gout, including 3
females and 44 males.
2. Age Range: The patients’ ages ranged between 40 and 70 years.
3. Gouty Nephropathy: Among the 46 patients, 20 males had been diagnosed
with gouty nephropathy, with 15 of them aged over 50.
4. Biochemical Analysis Results: Creatinine Levels: 20 patients had serum
creatinine levels above 130 mmol/l (normal creatinine levels for males: 62-106
mmol/l, females: 53-97 mmol/l).
Uric Acid Levels: All patients had elevated uric acid levels, confirming the
diagnosis of gout.
Patients over 50 years old: For those aged over 50, serum creatinine levels were
higher than 130 mmol/l, and uric acid levels exceeded 7 mg/dl (normal uric acid
levels for men: 3.5-7.2 mg/dl, women: 2.6-6.0 mg/dl).
Analysis:
Creatinine Levels: Elevated creatinine levels indicate potential
kidney dysfunction. In patients over 50, the high creatinine levels suggest a
greater risk of gouty nephropathy. Regular monitoring of serum creatinine is
essential for assessing kidney health in gout patients.
Uric Acid Levels: Elevated uric acid levels are characteristic of gout and
contribute to the formation of crystals in the kidneys and joints. In patients over
50, the higher uric acid levels indicate more severe progression of gout and an
increased risk of nephropathy.
Clinical Implications
: The relationship between age and biochemical
markers shows that gout and gouty nephropathy are more prevalent in older
patients, making early detection and management crucial to prevent further
complications.
Conclusion:
Elevated creatinine and uric acid levels are significant biochemical
indicators of gout and its complications, including gouty nephropathy. Patients
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
133
aged over 50 are at higher risk of kidney damage and need regular monitoring of
these markers. Early detection and appropriate treatment are key to improving
patient outcomes.
