CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
128
PATHOMORPHOLOGICAL COMPARISON DIAGNOSIS OF THORACO-
LUMBAR SPONDYLITIS OF THE SPINE AFTER COVID-19
Mahkamov N.J.
Andijan State Medical Institute, Ph.D. associate professor
nosirzonmahkamov5@gmail.com Andijan city
Hayrullaev A.A.
Andijan State Medical Institute, independent researcher
iqbol00033@mail.ru Andijan city
https://doi.org/10.5281/zenodo.13789895
The relevance and necessity of the topic is that the trend of treating
degenerative diseases of the spine in the world is becoming an increasingly
urgent task. The human spine is the main anatomical structure of the div and
participates in a number of physiological systems, including: ensuring the
integrity and mechanical protection of the spinal cord, preventing a number of
vertebrogenic diseases. Various chronic orthopedic diseases related to COVID-
19 have become not only the subject of close study, but also one of the most
pressing medical and social problems. Globally, there is an increasing number of
new scientific studies on various orthopedic diseases during the acute period of
the coronavirus infection and the subsequent permanent long-term orthopedic
consequences in the musculoskeletal system Spine in the world
A number of targeted scientific studies are being conducted to evaluate the
clinical and pathomorphological changes of spinal spondylitis from degenerative
dystrophic diseases. Research aimed at the analysis of different approaches to
the comparative diagnosis of the pathomorphological characteristics that
develop in the thoracic and lumbar regions of the spine during COVID-19
infection is of particular scientific and practical importance.
Objective: to improve the diagnosis of post-COVID-19 spinal spondylitis
through comparative analysis of clinical anamnestic data and morphological-
morphometric parameters
Material and examination methods: To study the topography and morphology of
degenerative and dystrophic changes in the thoracic and lumbar regions of the
spine after Covid-19, spinal spondylitis, disc herniation and a disc from 30 to 65
years old in the autopsy department of the Republican SSV Center for
Pathological Anatomy in Andijan we used the materials obtained in the surgical
practice with hernia.
Research results and their discussion: In the early period of development of
spinal spondylitis, necrobiotic changes develop due to narrowing and
thrombosis of blood vessels in the outer membrane and soft tissues around the
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
129
bone. First, the interstitial osteoid material becomes necrobiosis in the structure
of the vertebral bone, creating cavities with destroyed osteoblasts, osteoclasts,
and fibroblasts, then necrobiotic changes occur due to the development of
dystrophic and destructive changes in the hard columns of the bone. The III
period of the process of spinal spondylitis, during the period of the appearance
of hard necrosis foci. sequestrations from bone columns, structureless dendrites
from intermediate osteoid structures are determined. It should be mentioned
that in addition to these pathomorphological changes, calcinosis develops in
some areas of the tissue. As a result, sequestered hard and disc fragments must
be completely surgically removed, especially sequestered fragments (including
rare fragments that penetrate the subarachnoid space). determined that
pathomorphological changes should be determined by individual approach to
age, lifestyle and work activity. In our scientific study, it was found that the
proliferation of lymphohistiocytic cells was also observed in the soft tissue
around the vertebral bone.
Conclusion: In conclusion, it can be said that the development of spinal
spondylitis after COVID-19 from degenerative-dystrophic diseases in the
thoracic-lumbar area of the spine is confirmed faster and more than in other
areas, the clinical-pathomorphological course of sequestral hernia and
spondylitis processes are more severe, and the development of more
complications is confirmed.
SAULider’s, [18.09.2024 18:27]
Of course, the full diagnosis of diseases leads to an increase in the effectiveness
of treatment, which is a task performed for the social, economic development
and prosperity of our people.
The results of the conducted scientific research showed that histological
examination provides not only early diagnosis, but also earlier surgical practice
in studying the disease levels of patients and making a correct diagnosis.
References:
1.
. Villa JC, Husain S, van der List JP, Gianakos A, Lane JM. Treatment of pre-
collapse stages of osteonecrosis of the femoral head: a systematic review of
randomized control trials. HSS J 2016;12:261-271.
2.
Wang A, Ren M, Wang J. The pathogenesis of steroid-induced
osteonecrosis of the femoral head: A systematic review of the literature. Gene.
2018;671:103-109.
3.
Wang A, Zhao P. The key elements for biomolecules to biomaterials and to
bioapplications //Biomolecules. – 2022. – Т. 12. – №. 9. – С. 1234.
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
130
4.
Wang F., Kream R. M., Stefano G. B. Long-term respiratory and neurological
sequelae of COVID-19 //Medical science monitor: international medical journal
of experimental and clinical research. – 2020. – Т. 26. – С. e928996-1.
5.
Wang T., Azeddine B., Mah W., Harvey E.J., Rosenblatt D., Séguin C.
Osteonecrosis of the femoral head: genetic basis.Int Orthop. 2019;43 (3) :519–
530.
6.
Wu W. et al. Prognostic analysis of different morphology of the necrotic-
viable interface in osteonecrosis of the femoral head //International
orthopaedics. – 2018. – Т. 42. – P. 133-139.
