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ENSURING THE SAFE USE OF ANTIPYRETICS IN CHILDREN
Usmonov F.O., 614 - group, Faculty of Pediatrics
Scientific adviser: ass. Mavlyanova N. T.
TashPMI, Clinical pharmacology, UASh therapy
Relevance:
A boil in div temperature in children is one of the main reasons for seeking medical
help. Uncontrolled use of antipyretics, inadequate intake and dosage regimen can lead to the development
of serious adverse reactions.
Purpose:
Ensuring the safe use of antipyretics in children.
Materials and methods:
The analysis of literature data on the use of antipyretics in children was
carried out.
The results of the research and their discussion. It seems to be very important to discuss the question of
the rational use of antipyretic drugs in children. At the same time, in children with influenza and other
acute respiratory viral infections, the use of acetylsalicylic acid and it s derivatives is unacceptable due
to the extra risk of developing Reye's syndrome.
The World Health Organization recommends paracetamol and ibuprofen as antipyretics for children.
l.Ibuprofen can be used as a starting drug when paracetamol is contraindicated or ineffective.
Recommended dosage development: paracetamol - 10-15 mg / kg mass, ibuprofen - 5-10 mg / kg.
2.Re-use of antipyretic drugs is possible no earlier than 4-6 hours after the first dose.
Conclusion:
1.
Paracetamol is contraindicated in severe diseases of the liver, kidneys, hematopoietic organs, with a
deficiency of glucose-6-dehydrogenase.
2.
The simultaneous use of paracetamol with babriturats, anticonvulsants and rifampicin increases the
risk of developing hepatotoxic effects.
3.Ibuprofen is contraindicated in exacerbation of gastric ulcer and duodenal ulcer, aspirin triad, severe
violations of the liver, kidneys, hematopoietic organs, as well as diseases of the optic nerve.
4.
Metamizole sodium (analgin) is capable of producing anaphylactic shock, a sharp decrease in the
number of neutrophils (up to agranulocytosis), a collaptoid state with hypothermia (34.5-35.0 ° C). WHO
(in a letter dated 10/08/1991) did not recommend the use of analgin as an over-the- counter antipyretic
agent.
5.
Established a causal relationship between nimesulide intake and hepatotoxicity (jaundice - 90%).
References:
1.
Мищенко, Т. С., Здесенко, И. В., Линская, А. В., & Мищенко, В. Н. (2011). Новые мишени
терапевтического воздействия у пациентов с хронической ишемией головного
мозга. Международный неврологический журнал, (2), 7-13.
