S Smiyan, B Koshak
It is known that mortality among patients with the ankilosing spondiloartritis (AS) is 1,85 times higher than population level and is caused by cardiovascular pathology (CC).
Today the role of persistant inflammatory process in developing of the CC diseases owing to development of the dysfunction of endothelium (DE) docs not leave doubt. Considering it, the increased level of the S-jet protein, is considered as an independent predictor of development of cardiovascular diseases and their complications. For this reason, gains the special importance in development of DE and the CC pathology of an inflammation at patients with autoimmune diseases which constant attribute is actually inflammatory process.
Despite modem approach to treatment the ankilosing spondiloartritis from use of immunobio logical preparations, practically there arc no data on development of DE, influence of an inflammation on a state an endothelium and development of cardiovascular pathology in patients with the ankilosing spondiloartritis.
