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PHARMACOEPIDEMIOLOGICAL ANALYSIS OF THE PERFORMED
CONSERVATIVE TREATMENT IN PATIENTS WITH
CHOLELITHIASIS OF THE GERONTOLOGICAL GROUP OF FERGANA
Salakhidinov S.Z.
Mamasaliev N.S.
Tursunov X.X.
Mamasaliev Z.N.
Usmonov B.U.
Andijan State Medical Institute, Uzbekistan
https://doi.org/10.5281/zenodo.15130996
Relevance.
According to the WHO, in the modern treatment and diagnostic
process of cholelithiasis (CSD) it is important, especially in individuals of the
gerontological group (75-90 years and above), not only to provide scientific
information on a certain type of treatment (surgical or conservative) and clinical
and fundamental recommendations, but also to acquire modern innovative
technologies acceptable for preventive surgery and the ability to use them. For
the advanced development of CSD surgery in the 21st century, it is important to
identify the most susceptible individuals with high or very high risk for this
pathology and their special prevention to ensure the process of early detection,
effective
and
safe
treatment
(with
proper
pharmacovigilance,
pharmacoepidemiological screening) and the prevention of not only CSD itself,
but also formidable complications of cholecystectomy, cholecystostomy,
choledochotomy,
choledochomyotomy
and
transduodenal
sphincteropapillotomy.
The aim of the study
is to study the prevalence, pharmacoepidemiology of
cholelithiasis and its main risk factors among the male and female unorganized
population of the gerontological group of the Fergana Valley to enable
scientifically based planning and optimization of early diagnosis, prevention and
treatment of this disease.
The object of the study
was a contingent of 4,500 individuals of the
gerontological age population, formed using random number tables based on the
nominal electoral lists of men and women in three regions of the Fergana Valley;
as well as 779 patients with cholelithiasis who were undergoing inpatient
treatment in the regional multidisciplinary hospitals of Andijan, Namangan and
Fergana (for VEN analysis).
The subject of the study:
were the results of general clinical and
biochemical
blood
tests,
survey,
physical,
instrumental
and
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pharmacoepidemiological monitoring; as well as the method of "daily nutrition
reproduction" adapted to the peculiarities of Uzbek cuisine.
Research methods.
To solve the set tasks, epidemiological, clinical,
laboratory, biochemical, instrumental, pharmacoepidemiological and statistical
research methods were used, as well as the “daily nutrition reproduction”
method.
Results of the study:
In the regional surgical hospitals of Fergana, for the
treatment of cholelithiasis in gerontologically aged individuals, the
corresponding conservative therapy with basic drugs is used with the following
frequency levels: antihypertensive drugs - 8.4% (in the total number of those
examined with cholelithiasis), 0.0% (in women) and 8.4% (in men),
antispasmodics - 14.0%, 1.12% and 12.9% (
ꭓ
2=35.28; P<0.001; RR=0.087; 95%
CI=0.023-0.330), analgesics - 14.0%, 11.2% and 12.9% (
ꭓ
2=3.5,28; P<0.001;
RR=0.087; 95% CI=0.023-0.330), antibacterial drugs – 14.0%, 1.12% and 12.9%
(
ꭓ
2=35.28; P<0.001; RR=0.087; 95% CI=0.023-0.330), enzyme inhibitors –
14.0%, 1.12% and 12.9% (
ꭓ
2=3.5,28; P<0.001; RR=0.087; 95% CI=0.023-0.330),
infusion agents – 14.0%, 1.12% and 12.9% (
ꭓ
2=35.28; P<0.001; RR=0.087; 95%
CI=0.023-0.330), NSAIDs – 4.5%, 0.56% and 3.9% (
ꭓ
2=0.324; P>0.05;
RR=1.643; 95% CI=0.360-7.492), anticoagulants – 14.0%, 1.12% and 12.9%
(
ꭓ
2=35.28; P<0.001; RR=0.087; 95% CI=0.023-0.330) and proton blockers –
2.8%, 0.56% and 2.2% (
ꭓ
2=1.223; P>0.05; RR=2.875; 95% CI=0.554-14.93).
Conservative treatment is performed in 92.1% of women and 7.9% of men with
cholelithiasis [
ꭓ
2=252.8; P<0.001; RR=0.085; 95% CI=0.052-0.141]. The
analysis showed that in Fergana hospitals, the rationality of treating
cholelithiasis in the gerontological population (≥60-90 years) is 95.0%, and
compliance with international clinical guidelines is 96%. The risk of developing
pre- and postoperative complications is 4-5%, or the risk of such in
gerontological patients remains despite conservative therapy
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