STORAGE CONDITIONS AND SHELF LIFE DETERMINATION OF THE  HEPATOPROTECTIVE HERBAL TEA “HEPASILIMARIN”

G Kayumova; F Kayumov; Z Mamatkulov

66

Volume 5, Issue 10: Special Issue
(EJAR)

ISSN: 2181-2020

MPHAPP

THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL

CONFERENCE

“

MODERN PHARMACEUTICS: ACTUAL

PROBLEMS AND PROSPECTS

”

TASHKENT, OCTOBER 17, 2025

in-academy.uz

STORAGE CONDITIONS AND SHELF LIFE DETERMINATION OF THE

HEPATOPROTECTIVE HERBAL TEA “HEPASILIMARIN”

Kayumova G.G.

1

Kayumov F.S.

2

Mamatkulov Z.U.

3

Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan

e-mail: kildonferuz@mail.ru

https://doi.org/10.5281/zenodo.17318452

Relevance:

Herbal teas derived from medicinal plants have been traditionally and extensively

utilized for centuries in folk medicine as well as in modern pharmaceutical practice. They are valued
not only as supportive remedies but also as therapeutic agents with restorative and preventive benefits.
These properties are especially significant in maintaining and enhancing liver health, as the liver is
one of the div’s most vital organs responsible for detoxification and metabolic balance. Within this
group, the herbal tea “HEPASILIMARIN,” formulated from locally sourced medicinal plant raw
materials, has been scientifically investigated and confirmed to possess hepatoprotective activity in
pharmacological studies. Despite these beneficial effects, it is important to recognize that the overall
efficacy and safety of such herbal products are highly dependent on proper storage conditions and
strict adherence to the specified shelf life. Any deviation from these conditions can result in the loss
of bioactive compounds or reduced therapeutic effectiveness. Consequently, establishing the most
suitable packaging material and accurately determining the shelf life that guarantees the preservation
of the tea’s qualitative characteristics is not only a scientific necessity but also a critical practical task
for ensuring product stability, patient safety, and clinical usefulness.

The aim of the study.

To study the storage conditions of “HEPASILIMARIN” herbal tea in

various packaging materials and to determine the optimal storage duration and conditions based on
their impact on quality parameters.

Materials and Methods.

The object of study was the herbal tea “HEPASILIMARIN” with the

following composition: milk thistle seeds (

Silybum marianum

) – 2.0 g; peppermint leaves (

Mentha

piperita

) – 1.0 g; corn silk (

Zea mays

) – 2.0 g. The product was packaged in three types of containers

permitted for medical use: paper filter-bag + cardboard box; nylon filter-bag + cardboard box;
aluminum foil package (multi-use) + cardboard box. During storage, the following indicators were
evaluated: appearance, color, moisture content, particle size, weight per bag, amount of water-soluble
extractive substances, total flavonoids (as rutin), and microbiological purity. Storage experiments
were carried out under natural conditions — at room temperature (20 ± 2 °C, relative humidity 50–
65%) for 30 months, with analyses repeated every 6 months.

Results and Discussion.

Throughout the experiment, the content of bioactive substances and

the main quality indicators were preserved across all packaging types. However, samples stored in
aluminum foil packages demonstrated the highest stability. Nylon packages also maintained favorable
results, while some quality parameters were relatively lower in teas stored in paper filter-bags. The
effectiveness of packaging materials ranked as follows: aluminum foil > nylon > paper filter. Based
on the obtained results, it was established that the quality indicators of “GEPASILIMARIN” herbal
tea remain within acceptable standards for up to 2 years. Therefore, the use of aluminum foil or nylon
filter-bags is recommended in practice.

Conclusion.

The optimal shelf life of “HEPASILIMARIN” herbal tea has been determined as

2 years

. Packaging material plays a crucial role in maintaining product quality, with aluminum foil

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