96
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
PREPARATION OF CREAM BASED ON
CARTHAMUS TINCTORIUS
L. FLOWER
EXTRACT AND EVALUATION OF ITS QUANTITATIVE INDICATORS
Akhmedova M.K.
1
Akhmadova G.A.
2
Rizayeva N.M.
3
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: akhmedovamunojat6@gmail.com
https://doi.org/10.5281/zenodo.17322180
Introduction.
In recent years, the prevalence of dermatological diseases has been increasing,
leading to a significantly greater demand for effective and safe skin care products. Between 1989 and
2008, the number of dermatological products prescribed by physicians in the United States exceeded
320 million. This trend highlights the relevance of innovations in cosmetic and pharmaceutical
products. Carthamus tinctorius L. (safflower) flowers are rich in flavonoids, carotenoids, phenolic
compounds, alkaloids, essential oils, and other phytochemicals, and have long been used in traditional
medicine. This plant extract is recognized as a highly biologically active component in cosmetology.
Aim of the Study.
The primary objective of this study was to develop a cosmetic cream based
on Carthamus tinctorius L. flower extract, to determine its optimal composition, and to evaluate its
quantitative parameters.
Methods and Results.
Within the scope of the research, creams with different formulations
were prepared using safflower flower extract, and their physicochemical properties were investigated.
Two formulations were analyzed:
• Formula 1:
2.0 g extract, 5.0 g vaseline, 5.0 g amaranth oil, 7.0
g lanolin, and 1.0 g purified water. •
Formula 2:
2.0 g extract, 5.75 g amaranth oil, 5.75 g sunflower
oil, 4.5 g wax, 0.6 g Tween-80, and 1.4 g purified water.
To evaluate the creams’ quantitative indicators, physicochemical tests were carried out in
accordance with pharmacopoeial requirements. The pH value was determined according to Eur 2.2.3
using the potentiometric method. For this purpose, 1% solutions of each cream were prepared by
dissolving 1 g of cream in a 100 ml volumetric flask filled up to the mark with purified water and
heated to 80°C. After cooling to room temperature and filtering, the pH values were measured
potentiometrically.
Table 1
Physicochemical properties of the creams
Parameters
Cream No. 1
Cream No. 2
Appearance
Soft
Semi-solid
Color
Pale yellow
Pale yellow
Odor
Characteristic
Characteristic
pH
6.40
5.98
Colloidal stability
Stable
Stable
Thermal stability
Stable
Stable
Conclusion.
During the study, two types of cream formulations based on Carthamus tinctorius
L. flower extract were developed, and their physicochemical properties were evaluated. The results
demonstrated that both formulations exhibited good stability and were suitable for use. Moreover, the
presence of amaranth oil in the cream composition was found to play an important role in enhancing
biological activity. In the next phase, the dermatological properties and therapeutic effectiveness of
these creams will be investigated.
