102
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
SELECTION OF THE PRESCRIPTION OF A MEDICAL AND COSMETIC CREAM
WITH ANTI-INFLAMMATORY EFFECT
Baratova M.B.
1
Karieva E.S.
2
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: ibragim55555.2017@gmail.com
https://doi.org/10.5281/zenodo.17322439
Relevance:
Currently, the Uzbek market is dominated by imported medical and cosmetic
products, which outweigh domestic medicines. Given this fact, a number of plant extracts were
studied by the Department of Drug Formulation Technology at the Tashkent Pharmaceutical Institute.
Among them, the dry extract "Fitoinflam" was of particular interest, as it was originally developed
for use in dental practice. Given that a regulatory document has been approved for this dry extract,
which can be used as a substance for medicines and dietary supplements, we decided to conduct
research on the development of a therapeutic and cosmetic anti-acne cream in order to further
introduce it into domestic production.
Research objective.
Initial studies were aimed at selecting the formulation of a new therapeutic
and cosmetic anti-inflammatory cream.
Materials and methods:
The present research was based on a review and comparative analysis
of scientific literature, including articles by Russian and foreign scientists.
We used the following substances as the active principle of the cream being developed:
Phytoinflam dry extract (VFS 42 Uz-5712-2024), salicylic acid (GF RUz 12/2021:0366); camphor
(GF RUz 12/2022:1400); niacinamide (nicotinamide) (GF RUz 12/2021:0047).
The auxiliary ingredients were selected to perform the following functions: base and structure
formation, odor correction (fragrance), dissolution, emulsification, stabilization, emulsification, and
pH correction.
The doses of the active ingredients were agreed upon with pharmacologists, and the auxiliary
substances were selected based on scientific literature.
Results:
The selection of active ingredients was based on their therapeutic effect. For example,
"Phytoinflam" is a dry extract obtained by the method of circulation extraction from a herbal
collection of chamomile flowers, oak bark, and Stachys annua, which has anti-inflammatory and
wound-healing properties. Niacinamide is effective due to its anti-inflammatory and regenerative
properties, strengthening the skin barrier and reducing inflammation. Camphor has a mild skin-
irritating effect, which improves local blood circulation and increases blood flow. Salicylic acid
reduces sebum due to its seboregulatory properties, and it is also used as a brightening agent and
keratolytic.
Given the multi-component composition, we decided to use the mathematical planning of the
experiment to develop the formulation. The release of the active ingredient in biopharmaceutical
experiments was used as a response.
Using the method of mathematical planning, we selected the optimal auxiliary substances for
the composition of the therapeutic and cosmetic cream: aerosil and castor oil were chosen as the base
and structure-forming agents, glycerin was chosen as the emollient, and sodium tetraborate was
chosen as the emulsifier. In addition to these ingredients, we proposed purified water as the solvent,
tea tree essential oil (which also has anti-inflammatory properties) as the odor corrector, and citric
acid as the pH corrector.
103
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusions:
Thus, we have developed a formulation of a medical and cosmetic cream with
anti-inflammatory properties.
