151
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
PROSPECTS FOR THE DEVELOPMENT OF A WOUND-HEALING DRUG BASED
ON MICRONIZED KAOLINITE AND ESSENTIAL OILS OF KAZAKHSTAN
PLANTS
Kozhanova K.K.
Kadyrbayeva G.M.
Bekezhanova T.S.
Karaubayeva A.A.,
Zhaparkulova K.A.
Ziyat A.I.
Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
e-mail: kozhanova.k@kaznmu.kz, tel.: +7-701-738-86-25
https://doi.org/10.5281/zenodo.17328526
Relevance:
The problem of infected wounds remains one of the key challenges in clinical
practice. The growing prevalence of multidrug-resistant microbial strains and the increasing demand
for domestic medicines that combine antimicrobial activity, hemostatic effect, and the ability to
stimulate tissue repair processes are evident. Natural geomaterials (including kaolin/kaolinite) have
already demonstrated clinical efficacy as safe hemostatics and as matrices for the delivery of active
substances, while essential oils (EOs) of Kazakhstan’s plants exhibit pronounced antimicrobial and
anti-inflammatory activities.
Aim of the study.
To conduct a critical review of the scientific literature on the use of
micronized kaolinite in combination with essential oils, to evaluate pharmacological, technological,
and toxicological aspects, and to develop recommendations for creating a wound-healing drug on
their basis.
Material (literature review).
The review covered: experimental data on kaolinite as a
hemostatic and carrier agent; studies on polymer–clay dressings with antimicrobial properties; data
on the composition and bioactivity of EOs from Kazakhstan plants; publications on the safety of EO
components; and reviews on release kinetics and stability of EOs in matrices.
Results.
Analysis of the literature showed that kaolinite provides a rapid hemostatic effect and
can serve as a matrix for creating porous dressings with proven clinical efficacy. Essential oils
containing thymol, carvacrol, and other phenolic compounds demonstrate antibacterial, antifungal,
and regenerative properties, while their incorporation into polymer matrices enhances antimicrobial
effects and accelerates epithelialization. The feasibility of “clay + essential oil” compositions has
been demonstrated, ensuring controlled release and improved stability of bioactive components. A
limitation is the presence of potentially toxic compounds in EOs, necessitating dosage optimization,
selection of safe essential oils, and mandatory preclinical toxicological evaluation.
Conclusion.
The combination of micronized kaolinite and essential oils of Kazakhstan plants
represents a promising platform for the development of a local wound-healing drug.
Recommendations for further research include: selection of prospective essential oil-bearing plants
with proven pharmacological activity; extraction and study of essential oils; choice of dosage form
(gels/sponges/dressings) with evaluation of adsorption and release kinetics; formulation
development; stepwise biological assessment in vitro (MIC, cytotoxicity, collagenogenesis), followed
by controlled in vivo wound-healing models and systemic toxicology; compliance with regulatory
requirements for preclinical safety. If these conditions are met, the project has high translational
potential, particularly when utilizing locally available plant raw materials. This study was carried out
within the framework of the intramural grant of Asfendiyarov KazNMU «Development of technology
152
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
and standardization of pharmaceutical products based on kaolinite clays and essential oils of
medicinal plants».
