374
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY OF
TAMARIX
RAMOSISSIMA
: A REVIEW
Daulbaev A.O.
Kozhanova K.K.
Kadyrbaeva G.M.
Rakhymbaev N.A.
Kazakh National Medical University named after. S.D. Asfendiyarov
Kazakh National Medical University, Almaty, Kazakhstan.
E-mail: arai_14@bk.ru, tel. +7 778 122 77 95
https://doi.org/10.5281/zenodo.17337937
Relevance: Tamarix ramosissima
is a shrub plant widely distributed in arid regions. In recent
years, its chemical composition and pharmacological properties have been investigated, which opens
prospects for the development of new phytopreparations. Phytochemical analysis confirms the
presence of flavonoids, phenolic compounds, terpenoids, alkaloids and saponins in the plant, which
determines its biological activity.
PURPOSE:
To review the phytochemical properties of
T. ramosissima
and its biological
activity in order to assess the prospects of its use in pharmacy and medicine.
Materials and Methods:
The
review is based on the analysis of scientific publications from
PubMed, Scopus, Web of Science and Google Scholar. Methods of isolation and identification of
active compounds (
thin-layer chromatography (TLC), high-performance liquid chromatography
(HPLC), gas chromatography-mass spectrometry (GC-MS
)) as well as studies of antioxidant,
antimicrobial, anti-inflammatory and cytotoxic properties of
T. ramosissima
are reviewed.
Results:
Phytochemical analysis of
T. ramosissima
revealed the content of flavonoids (up to
3.5% of dry weight), phenolic compounds (up to 2.8%), and saponins (1.2%). The antioxidant activity
of the ethanolic extract is 78.5% by DPPH test, which is comparable to that of ascorbic acid.
Antimicrobial activity was confirmed against
Staphylococcus aureus
(18 mm growth
suppression zone),
Escherichia coli
(15 mm zone),
Pseudomonas aeruginosa
(12 mm zone) and
Candida albicans
(10 mm zone). Phenolic compounds (gallic acid, quercetin) and flavonoids
(kaempferol, rutin) have an effect by damaging the membranes of pathogens and inhibiting their
enzymes.
Anti-inflammatory effect is associated with inhibition of the production of pro-inflammatory
cytokines (
IL-6, TNF-α
) by 35-40%. Studies have shown that
T. ramosissima
extracts reduce malonic
dialdehyde (MDA) levels by 25%, indicating its antioxidant potential. The active compounds of the
plant were also found to inhibit the activity of COX-2 and 5-LOX enzymes, which confirms its anti-
inflammatory effects. In addition, the extracts contribute to the stabilization of lysosomal membranes,
reducing the secretion of inflammatory mediators.
In vitro cytotoxic studies have shown that
T. ramosissima
extract reduces the viability of HeLa
cell line by 45% at a concentration of 100 µg/mL, and induces apoptosis of A549 (lung cancer) cell
line by 50% at a concentration of 200 µg/mL. In studies on a carcinoma model in mice, a 30%
reduction in tumor volume was observed when the extract was orally administered at a dose of 50
mg/kg for 14 days. Further
in vivo
studies are needed to determine its therapeutic potential in the
treatment of cancer.
Conclusions: Tamarix ramosissima
is a promising source of biologically active compounds.
Further research is aimed at standardizing the phytochemical composition, studying the mechanisms
of action of its active components, as well as conducting
in vivo
studies to clarify the
375
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
pharmacokinetics and safety of compounds for their potential use in the development of new drugs
for the therapy of inflammatory and oncological diseases.
