457
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
THE IMPORTANCE OF TREATING STOMACH AND DUODENAL ULCER
DISEASE IN PHYTOTHERAPY AND ITS ANALYSIS THROUGH THE EXAMPLE
OF MEDICINAL PLANTS
Sultonova R.X.
Ko‘lboyeva.F.D
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: kulboyeva.feruza1992@gmail.com
https://doi.org/10.5281/zenodo.17342317
Relevance.
In modern medicine, one of the most pressing challenges is the increasing
prevalence of gastrointestinal disorders, particularly gastric and duodenal ulcers. The primary
etiological factor of these conditions is the bacterium
Helicobacter pylori
, which damages the
protective mucosal barrier of the gastrointestinal tract, disrupts gastric acidity, and initiates
inflammatory processes. Peptic ulcer disease is considered one of the most widespread internal
pathologies, requiring a comprehensive therapeutic approach. The main objectives of treatment are
pain relief, ulcer healing, prevention of complications, and reduction of recurrence, making this
condition a highly relevant issue in contemporary healthcare.
Aim of the Study:
To examine the effects of phytotherapeutic preparations containing
Achillea
millefolium
(common yarrow),
Calendula officinalis
(marigold), and
Glycyrrhiza glabra
(licorice) in
the treatment of peptic ulcer disease within phytotherapy.
Methods:
To highlight the research, relevant scientific articles and literature sources were
analyzed (Phytotherapy, 2023).
Results:
Biologically active compounds play a crucial role in the treatment and recovery
processes of gastric and duodenal ulcer disease.
Achillea millefolium
(common yarrow) contains
flavonoids such as apigenin and luteolin, as well as tannins. These compounds exert anti-
inflammatory effects by suppressing the release of inflammatory mediators. They may help reduce
swelling in inflamed tissues and alleviate pain.
Glycyrrhiza glabra
(licorice) has long been widely
used in both Eastern and Western medicine as a medicinal plant. Its diverse pharmacological
properties are primarily associated with biologically active compounds found in its roots. The anti-
inflammatory effects of licorice are mainly attributed to glycyrrhizin, which undergoes metabolic
transformation in the div and exhibits corticosteroid-like activity. This occurs through the inhibition
of inflammatory mediators such as prostaglandins and leukotrienes. Owing to these properties,
licorice is applicable not only in respiratory diseases but also in conditions such as arthritis, dermatitis,
and other inflammation-related disorders. Flavonoids of licorice (e.g., liquiritin, liquiritoside)
together with glycyrrhizin are considered effective in the treatment of gastric and duodenal ulcers.
They enhance the protective mechanisms of the gastric mucosa by stimulating mucus secretion,
promoting prostaglandin synthesis, and potentially exhibiting activity against
Helicobacter pylori
.
Additionally, licorice has mild spasmolytic properties that help relax smooth muscle spasms in the
gastrointestinal tract.
Calendula officinalis
(marigold), commonly known as calendula, is another
widely used medicinal plant in traditional medicine. Inflammation of the gastric or intestinal mucosa
often leads to conditions such as gastritis and peptic ulcers. Flavonoids and triterpenes present in
calendula help reduce inflammation by inhibiting the release of inflammatory mediators, thereby
decreasing swelling and pain in the gastric and intestinal walls. Its antioxidant compounds (flavonoids
and carotenoids) neutralize free radicals, protecting cells from damage and supporting mucosal
458
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
healing. Moreover, calendula has the ability to stimulate cell regeneration and increase collagen
synthesis, which accelerates the healing of erosions and ulcers in the stomach and intestines.
Conclusion:
The analysis of scientific articles and literature indicates that phytotherapeutic
preparations containing
Achillea millefolium
(common yarrow),
Calendula officinalis
(marigold), and
Glycyrrhiza glabra
(licorice), when administered in appropriate doses and under medical supervision,
are effective in both the treatment and prevention of gastric and duodenal ulcer disease.
