514
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
REVIEW OF CURRENT DATA ON GOLDEN HARE’S EAR (
BUPLEURUM AUREI
FISCH.) AND PROSPECTS FOR ITS USE IN PHARMACEUTICAL PRACTICE
Ashirov M.Z.
Toizhanov B.K.
S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
https://doi.org/10.5281/zenodo.17343697
Relevance.
Medicinal plants are a valuable source of biologically active substances (BAS).
Among them, a promising object is golden hare’s ear (
Bupleurum aurei
Fisch.), traditionally used in
the treatment of liver and gastrointestinal diseases. Modern studies confirm its rich chemical
composition and pharmacological potential.
Purpose of the study.
To summarize data on the phytochemistry and pharmacological
properties of
Bupleurum aurei
, as well as to assess the prospects for its use in pharmacy.
Materials and methods.
An analysis of dissertations, patents, and articles from PubMed,
Scopus, and RSCI databases was carried out, with evaluation of the chemical composition and
pharmacological activity of the plant.
Results.
In the herb of
B. aurei
flavonoids (2.1-2.8 %), saponins (up to 4.5 %), and phenolic
compounds (8.0 ± 0.5 % in dry extract) were identified. Plant extracts showed hepatoprotective, anti-
inflammatory, and antioxidant effects. At a dose of 100 mg/kg, the ethanol extract reduced ALT and
AST activity in animals by 30-35 %; the flavonoid fraction reduced inflammation by 28 %; and
antioxidant activity reached 70-75. Polysaccharide complexes stimulated the immune response [9].
At the same time, potential toxicity risks of certain saikosaponins are noted.
Conclusions.
Bupleurum aurei
Fisch. is a promising source of BAS. Its further study,
standardization, and development of extracts may contribute to the creation of domestic herbal
medicines, especially with hepatoprotective and immunomodulatory activity.
