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VOLUME
Vol.05 Issue04 2025
PAGE NO.
31-35
10.37547/ijmscr/Volume05Issue04-06
Study of Specific Activities of Black Seed Oil with
Vitamin E and Black Seed and Sesame Oil with Vitamin
E
Zaynutdinov Khikmatulla Sunnatovich
Uzbekistan Professor, Institute of Pharmaceutical Education and Research, Training and Retraining Center, Uzbekistan
Aliev Ubadulla Erkinovich
Associate Professor, Institute of Pharmaceutical Education and Research, Uzbekistan
Abdijalilova Zilola Khikmatullaevna
Associate Professor, Institute of Pharmaceutical Education and Research, Training and Retraining Center, Uzbekistan
Ergasheva Dilafruz Zaripovna
Assistant Institute of Pharmaceutical Education and Research, Uzbekistan
Received:
26 February 2025;
Accepted:
22 March 2025;
Published:
25 April 2025
Abstract:
Blackthorn is an annual plant with purple or white flowers. It is common in Central Asia, the Caucasus,
and the Balkan Peninsula. Black cumin seed oil is used in the beauty industry, pharmacology, and cooking. As a
dietary supplement, this product is used as additional help for the div: cumin contains useful substances,
vitamins, and minerals that have a beneficial effect on well-being. One of the main components of black cumin oil
is thymoquinone. This is a powerful antioxidant that has an anti-inflammatory effect, increases overall tone, and
improves performance. It is also a source of fatty acids, phosphorus, potassium, magnesium, and calcium.
Keywords:
Fatty acids, phosphorus, potassium, magnesium, and calcium.
Introduction:
The oil contains a complex of useful
substances, including amino acids with vitamins and
phytosterols. Thymoquinone. Biologically active
component
of
cumin.
The
effectiveness
of
thymoquinone in the treatment of a number of
diseases has been proven. These include Alzheimer's
disease, Parkinson's disease, liver dysfunction,
periodontal disease, stomatitis, cancer and many
others.
Thymoquinone
fights
inflammation,
participates in metabolism and relieves pain.
Phytosterols. Substances that help remove cholesterol
from the div. Among plant products, vegetable oils
are record holders in phytosterol content. They play a
special role for the skin, as they produce collagen and
reduce its loss. Amino acids. More than 85% of black
cumin oil is fatty acids. The main one is the
polyunsaturated fatty acid omega-6. In addition, the oil
contains omega-3 and omega-9 acids. The acid complex
regulates
cholesterol
levels,
removing
“bad”
cholesterol from the blood and increasing “good”
cholesterol. Acids support the endocrine system,
improve metabolism and strengthen blood vessels. The
caloric content of 100 grams of butter is 890 kcal. [1].
One of the ways to find a source of new highly effective
and safe medicines is to turn to the centuries-old
experience of traditional medicine. Nigella sativa can
be considered one of such potential sources of
medicines taken from traditional medicine. The history
of its use goes back about 2000 years, and the seeds of
this plant (Semen Nigellae sativae), also known as black
cumin, are used. Today, one commercial product is
obtained from nigella seeds - fatty oil (nigella oil) - by
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International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265)
cold pressing, used as a biologically active food
supplement. The active substances of nigella oil are a
complex of essential acids and terpenoid compounds.
These and other valuable pharmacologically active
substances contained in nigella seeds give reason to
consider this raw material promising for obtaining not
only useful food and parapharmaceutical products, but
also medicines. In order to identify the prospects for
using Nigella sativa in official medicine, it seemed
appropriate to first analyze and summarize the
available results of the pharmacochemistry of this
plant. Black cumin oil can help strengthen the immune
system, reduce allergic reactions and normalize weight.
Alleviates the symptoms of rheumatoid arthritis. In
2016, 43 women diagnosed with mild to moderate
rheumatoid arthritis were divided into two groups: one
took a placebo every day, the other took black cumin
oil. After a month, patients receiving the oil showed a
reduction in symptoms of the disease, a decrease in the
level of inflammation markers in the blood and joint
swelling [1-3].
May help with allergic rhinitis. There is still no clear
understanding of why some people are susceptible to
allergies and others are not. There are opinions that
this disease can be inherited. In some cases, patients
suffering from allergies are prescribed medications for
the symptoms. Analysis of the healing properties of
black cumin oil has shown that it helps in the treatment
of sinusitis due to its anti-inflammatory and
antihistamine properties [2-6].
According to an article published in the American
Journal of Otolaryngology, black seed oil reduced nasal
congestion, itching, runny nose, and sneezing within
two weeks of starting to take it [6,7].
Helps fight diabetes. Scientists have found that the use
of black cumin oil can help fight diabetes. "Roman
coriander" helps lower blood sugar and cholesterol
levels, but clinical trials are needed to confirm this
effect.
Alleviates asthma symptoms. Chronic respiratory
disease occurs as a resul
t of a person’s encounter with
an allergen or triggering factors. According to research
published in 2017, people with bronchial asthma who
took capsules with black cumin oil felt better [4, 8,10].
Helps normalize weight. During the experiment,
women were divided into two groups: one group
consumed black cumin oil, the other group
—
a
placebo. All subjects followed a low-calorie diet for
eight weeks. At the end of the period, the weight, waist
circumference, and blood cholesterol levels of women
who took the oil decreased more significantly than
those who received a placebo. Another study in which
overweight women exercised and took black cumin oil
showed that after eight weeks of such a regimen, their
cholesterol levels decreased.
Black cumin oil is also used as an aid in digestive
disorders, headaches, high blood pressure, eczema,
and hepatitis C. However, its positive effect on their
course has not yet been fully studied and requires
additional research [11,12]. Black cumin oil contains
quite a lot of unsaturated fatty acids, of which about
60% are omega-6 and only 24% are omega-9, an
important lipotropic factor phosphatidylcholine,
bioflavonoids, phytosterols, saponins, B vitamins (B1,
B2, B3, B6, and B9), D, C, E, and carotenoids (precursors
of vitamin A), eight essential amino acids, and the most
valuable
and
biologically
active
component,
thymoquinone, which is responsible for the beneficial
properties of the oil [13].
In naturopathic medicine, the oil is traditionally used as
a powerful anti-inflammatory, analgesic, hepato- and
nephroprotective, antipyretic, antibacterial and
immunomodulatory agent. It is worth noting that today
there are already data from small RCTs (randomized
controlled trials) that confirm the antibacterial,
antioxidant
(anti-inflammatory),
cytoprotective,
hypoglycemic and hypolipidemic properties of
caraway, as well as its ability to bronchodilate and
modulate the immune response. The antitumor effect
on animals is also being actively studied, where special
properties are due to the active thymoquinone,
nigellidine, alpha-hederin included in the composition,
which are able to enhance the immune response at the
molecular level. The effect of caraway on angiogenesis
(the growth of new vessels) is also known, which
requires special care in studying due to the fact that it
is especially intense in tumor processes.
Black cumin oil has a wide range of pharmacological
activity and is therefore widely used in folk medicine in
Eastern countries. Today, there are a large number of
scientific papers devoted to the study of the
pharmacological activity of this plant material [14].
Promotes strengthening and enhancing immunity.
Source of vitamin E and microelements.
METHODS
The study used the “Methodological recommendations
for asses
sing the effectiveness of dietary supplements”
edited by M.M. Ruzieva, approved by the Ministry of
Health on 04.06.2004 [17].
Purpose of the research: Evaluation of the
effectiveness of the dietary supplement "Black cumin
oil with vitamin E". Evaluation of the effectiveness of
the dietary supplement "Black cumin and sesame oil
with vitamin E".
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International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265)
RESULTS AND DISCUSSION
The efficiency of the dietary supplement was studied by
the method of determining the quantitative
characteristics of activity under mixed (anaerobic-
aerobic) power loads. For the experiment, a model of
swimming white mice with a load to failure was used.
The initial indicator of animal performance is the
maximum time of swimming with a load, the mass of
which is equal to 7% of the animal's div weight at a
water temperature in the tank from + 29 ° C to + 30 ° C.
The estimated indicator is the time of swimming to
failure, recorded during control tests in the dynamics of
observation after the introduction of the dietary
supplement. For this, 12 mice were weighed and
marked. To assess the swimming time, a 20X20X80 cm
organic glass tank filled with water was used, the
distance from the water surface to the edge of the tank
was at least 10 cm.
The animals were divided into 2 groups of 6 animals
each, the dietary supplements were administered as
follows:
Group 1 - control - water;
Group 2 - experimental - intravenous dietary
supplement "Black cumin oil with vitamin E" The
animals of the experimental groups were placed in
water 15 minutes after the administration of the
dietary supplements. The obtained data were
processed using the "STATISTICSA" program [16].
The obtained results showed that when the dietary
supplement was introduced into the experimental
group, the physical activity of the mice increased,
extending the time the mice spent swimming with a
load by 18% compared to the mice in the control group
(Table 2).
Table 2
№
жив.
Вес, г
Доза БАДа
в мл/кг
Продолжительность
плавания в мин
%
эффекта
Контрольная группа
М ±
m 19-21
5
38,9 ± 1,2
100
БАД «МАСЛО черного тмина с витамином Е»
М ±
m 19-21
5
46,2 ± 0,69
118
Note: *- reliability of differences in comparison with the control at P<0.05.
Thus, the conducted studies have shown the effective
effect of the biologically active supplement "Black
cumin oil with vitamin E" during physical activity.
"Black cumin and sesame oil with vitamin E" Helps
strengthen and improve immunity. Source of vitamin E
and microelements. Method of administration and
dosage: 1 (take orally 30 minutes before meals or 2
hours after meals, 2-3 capsules 2 times a day. The
effectiveness of the dietary supplement was studied by
determining the quantitative characteristics of activity
under mixed (anaerobic - aerobic) power loads. For the
experiment, a model of white mice swimming with a
load to failure was used. The initial indicator of animal
performance is the maximum swimming time with a
load, the mass of which is equal to 7% of the animal's
div mass at a water temperature in the container
from + 29 ° C to + 30 ° C. The estimated indicator is the
swimming time to failure, recorded during control tests
in the dynamic observation after the introduction of
the dietary supplement. For this, 12 mice were weighed
and marked. To assess the swimming time, a 20X20X80
cm organic glass container filled with water was used,
the distance from the water surface to the edge of the
container was not less than 10 cm.
The animals were divided into 2 groups of 6 animals
each, the dietary supplements were administered as
follows:
1. Group - control - water;
2. Group - experimental - intravenous dietary
supplement "Black cumin and sesame oil with vitamin
E" at a dose of 5 ml / kg.
The experimental animals of the 1st group were
lowered into water 15 minutes after the introduction
of dietary supplements. The obtained data were
processed using the program "STATISTICS". [16].
2. The results obtained showed that when the dietary
supplement was introduced into the experimental
group, the physical activity of the mice increased,
extending the time the mice spent swimming with a
load by 12% compared to the mice in the control group
(Table 2).
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International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265)
Таблица
2
№
жив.
Вес, г
Доза БАДа
в
мл/кг
Продолжительность
плавания в мин
%
эффекта
Контрольная группа
М ±
m
19-21
5
42,2 ± 0,97
100
БАД «Масло чёрного тмина и кунжут с витамином Е»
М
±m
19-21
5
47,3 ± 1,0
112
Примечание: *
-
достоверность различий в
сравнении с контролем при Р<0,05.
Таким
образом,
проведенные
исслсдования
показали эффективное воздействие биологичсски
активной добавки «Масло черного тмина и кунжута
с витамином Е» при физичсских нагрузках.
CONCLUSION
1. Полученные результаты показали, что при
введении БАДа в опьтной группе физичсская
активность мышей увеличилась, удлинив время
плавания мышей с грузом на 18 % по сравнению с
мышами контрольной группы. Экспериментальное
изучение биологически активной добавки «Масло
черного тмина с витамипом Е» показало, что
биологическая активная добавка к пище обладает
общеукрепляющим действием.
2.Экспериментальное
изучение
биологически
активной добавки «Масло черного тмина
и кунжута
с витамином Е» показало, что биологическая
активная
добавка
к
пише
обладает
обшеукрепляющим действием.
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