The article contains a short bibliographic review on progressive familial intrahepatic cholestasis, which presents not only the classic 3 types of the disease, but also its new variants, as well as other genetic diseases manifested by cholestatic liver damage in young children. The genetic, pathophysiological and clinical aspects of the pathology are considered. Clinical polymorphism of these diseases is shown. A clinical case of the diagnosis of progressive familial cholestasis in a 2-month-old child with genetic verification of the diagnosis and successful treatment, including liver transplantation, is presented. Two mutations in a heterozygous state have been identified: the previously described pathogenic mutation CM033442 and a previously undescribed mutation in the PGM1 gene.
The dynamics of morphological and biochemical parameters of
the blood of broiler chickens when using the Reasil ® Humic Health feed additive was revealed. An increase in protein, hemoglobin, leukocytes and erythrocytes was found
in the experimental groups compared with the intact group by 4 g/l, 12 g/l, 0.8x10 9 /l and 0.8x10 12 /l, respectively
Nikita Dmitriev, Vladimir Salautin, Alexei Vasiliev, Konstantin Korsakov