There was data on the clinic of polyradiculoneuritis as early as the middle of the 19th century, the exact localization of their foci was unknown. However, the lesion occurs in the central nervous system (CNS). In 1864, Dumesnil recorded the observation of transient paralysis as a result of damage to the peripheral nerves. In addition, Landry also made independent clinical observations. Histopathology of polyradiculoneuritis before 1880 Although data were not available, a group of researchers led by Deger studied the pathological causes of diphtheria paralysis. In the same year, Gombo developed an experimental model for the demyelination of peripheral nerves. Of lead and arsenic poisoning, diabetes, leprosy, alcoholism, and beriberi also cause nerve damage and paralysis [2, 5, 11, 23, 29].