Chronic hypertrophic rhinitis lead to the breakdown of the normal functioning of the body because of a violation of respiratory function, leading to circulator}' and tissue hypoxia, biochemical disturbances, including lipid metabolism and activity of the antioxidant system, which is accompanied by the development of the inflammatory reaction of the nasal mucosa; breach of natural immunity, as well as organic lesions of the paranasal sinuses, pharynx, larynx, lower respiratory tract. The examination and treatment of patients with chronic hypertrophic rhinitis who after surgical treatment along with conventional treatment included medication elfunat (ethylmethylhydroxypyridine succinate). Use of the drug has contributed elftinat: reduction of postoperative inflammatory reaction region and improve the activity of reparative tissue of the nose, the normalization of blood lipid peroxidation system and morpho-functional restoration layer of nasal mucosa.