Viruses are the etiological factor in 15% of all oncopathologies in the world and lead to the development of virus-associated tumors. Viral infection contributes to oral potentially malignant disorders that are prone to malignant transformation. The peculiarity of development is that the virus can be in a latent state for many years in the body and then promote in favorable conditions.
The aim of the study is to contribute to the effectiveness of the methods of the early diagnosis of precancers and oncological transformation of the oral mucosa, taking into account the etiopathogcnctic features of the progression of tumors. 457 patients of both sexes aged 18 to 65 years with various diseases of the oral mucosa were examined, of which 14.9% were earners of the human papilloma virus (HPV) and The Epstein-Barr virus (EBV).Methods of research: clinical, analytical, autofluorescent stomatoscopy, liquid cytology, PCR diagnostics of HPV and EBV. The introduction of antiviral drugs into the standard therapy made it possible to achieve the complete decurrence of pathological lesions and achieve a stable and longterm remission.
S Gazhva, J Ibragimova, V Ryabova, Alexandra Navolokina
Precancerous lesions of oral mucosa can be considered as diseases, which tend to maligning in various percent.Clinic picture is the same for such diseases. Pathology changes of oral mucosa are absent on early stages, but in malign process there are histological of oral carcinoma examined. Such diseases cause problems affecting social and daily life of the patient. The aim of the study was to improve the diagnosis of precancerous processes, as well as cancer of the oral mucosa, using minimally invasive examination methods. On the basis of the Department of Hospital Therapeutic Dentistry of the Tashkent State Dental Institute, in 2017- 2020, 50 patients with precancerous diseases of the oral mucosa were examined at the age of 25- 80 years. Early detection of potential precancerous processes allows avoiding interventional diagnostic methods, as well as reducing the risk of developing cancer of the oral mucosa.