Today, Uzbekistan is opening up to the whole world. One of the factors in the development of any state is that it has its place in the world community within the framework of important organizations. Uzbekistan has introduced various diplomatic mechanisms to accelerate the process of active interaction and mutually beneficial cooperation with the region and the world. One of the most important organizations in our country is the Shanghai Cooperation Organization. The rich history and close cultural ties between the SCO member states predetermine wide cultural and humanitarian cooperation within the organization. In this sense, it is worth noting that a hundred years ago the space of the SCO countries was connected by the ancient routes of the Silk Road. It is also deeply symbolic that by the 21st century, the countries of Eurasia are ready to develop new economic, cultural and humanitarian ties, reviving ancient traditions in the context of globalization. Some political and economic changes in the world require that only interstate cooperation be adapted to the principles of public diplomacy. Cultural and humanitarian cooperation has a growing tendency to develop mutual understanding, mutual enrichment and integration of cultures, creating a solid social basis for disseminating information and knowledge about the traditions and customs of peoples in the SCO space. Uzbekistan has long been associated with the people of the SCO space through ethnic, linguistic, religious and other ties. It was the land of Uzbek that served as a bridge connecting these links. Therefore, the most important direction of Uzbekistan’s foreign policy is cooperation with the SCO membe countries. Therefore, the possibility of further strengthening the role of Uzbekistan in all areas is an urgent problem. This article describes the cultural and humanitarian cooperation between Uzbekistan and the SCO, multilateral diplomacy in this area and the contribution of Uzbekistan to the development of this sector within the organization