Adenoviral conjunctivitis is an inflammatory disease of the conjunctiva that spreads at the epidemic level, the main reason for which is explained by the fact that it is rapidly spread by airborne and domestic routes and has a high degree of contagiousness. In clinical practice, viral eye pathologies develop the background of upper and lower respiratory (especially rhinitis, sinusitis, tonsillitis, bronchitis) and antibiotics are often used to treat bacterial complications in this category of patients. As a result, the balance of the immunomicrobiological environment in the intestines of some patients is disturbed [1,2,7] In this contingent of patients, eye pathologies of viral etiology persist for a long time. In modern practice, an integrated approach is used to increase the effectiveness of the prevention and treatment of adenoviral conjunctivitis. In addition, complex treatment of adenoviral conjunctivitis is required that the adequate use of antiviral and immunomodulatory drugs, as well as the inclusion new group of drugs in the treatment algorithm for increasing effectiveness and eliminate symptoms of this disease [3,5]. Probiotics stimulate the body's specific (antibody and immune system) and non-specific (skin, mucous membranes and tears) immunity by restoring the normal intestinal microflora balance, resulting in activation of cellular and humoral immune processes. The use of modern probiotics during treatment period decreased the production of cytokines in the patient's body in the same time increased of endogenous interferon’s concentration in the blood [1,3,4,6]. Even during an epidemic of adinoviral conjunctivitis, the inclusion of multi-component probiotics such as Bifolak Zincum + C + D3 in the complex treatment plan is effective and safe.
Purpose: to study the efficacy and tolerability of the domestic drug cromoviz in the treatment of allergic conjunctivitis.
The state of the organ of vision in 60 patients (120 eyes) with allergic conjunctivitis was studied. Depending on the therapy, the patients were divided into two groups of homogeneous clinical manifestations. At the same time, the patients of the main group (30 patients) were instilled with the drug Cromoviz (Uzbekistan), 2 drops 4 times a day for 4 weeks. Patients of the control group (30 patients) were instilled with Aycrol according to the same scheme.
The obtained research results showed that the use of the domestic drug cromoviz against the background of basic treatment is expressed in a decrease in subjective complaints of patients and a significant clinical effect in 95.9% of cases. The revealed economic efficiency of the drug action indicates the achievement of the maximum level of therapeutic result at an acceptable price for the patient and therapeutic-prophylactic institution. Cases of side effects and intolerance to the domestic drug cromoviz were not identified in our studies.
In the complex treatment of inflammatory eye diseases, anti-inflammatory therapy takes the leading place. The use of glucocortico steroids, which have powerful anti-inflammatory and antiallergic effects, carries the risk of serious side effects. Therefore, it was quite logical to develop and introduce into ophthalmological practice non-steroidal anti-inflammatory drugs, which are only slightly inferior to them in their anti-inflammatory activity. On the basis of a cytological analysis of the state of the conjunctiva, to assess the effectiveness of a new domestic ophthalmic drug "0.5% benzketozone ointment" in the treatment of conjunctivitis and blepharitis of infectious etiology. Materials and methods. To assess the effectiveness of 0.5% benzketozone ophthalmic ointment (Registration certificate No. 06-07.), A study was carried out on 134 (218 eyes) patients. In the control group, patients received traditional treatment, in the main group, 0.5% benzketozone ointment was additionally prescribed to the traditional treatment. Cytological examination was carried out by the method of modified impression cytology. Results. The data of modified impression cytology showed that the inclusion of benzketozone ointment in the traditional treatment significantly reduces the phenomena of exudation and proliferation, which at the subcellular level is manifested by a decrease in the number of basophils and eosinophils, restoration of the structure of epithelial cells and normalization of the nuclear-cytoplasmic ratio at an earlier time than in control groups, a faster decrease in the preparations of protein and tissue detritus. Conclusion. The inclusion of benzketozone eye ointment in the complex of traditional therapy increases regenerative activity, improves metabolic processes and alleviates the symptoms of inflammatory eye lesions
The problem of treating inflammatory diseases of the anterior segment of the eye, in particular chronic allergic conjunctivitis, blepharoconjunctivitis , continues to be relevant. In addition to the pronounced subjective discomfort, cosmetic defect, these diseases pose a danger to the cornea. Our study was aimed at studying the effectiveness of Floxal antibacterial ophthalmic ointment - in the treatment of acute and chronic diseases of the eyelids and conjunctiva.
The study involved 76 patients with children (46 boys and 30 girls) aged from 9 to 15 years, 34 of them - with allergic conjunctivitis and rhinosinusitis, 24 - with chronic recurrent obstructive bronchitis (preasthma), 18 - with asthma. Duration of illness ranged from a few months to 5 years examination. To clarify the rheological properties of blood there were determined electrical breakdown of the membrane, the electrophoretic mobility, the zeta potential of the membrane of erythrocytes and blood viscosity. The extent and intensity of the rheological properties of blood disorders in association with other clinical and laboratory data has prognostic significance in the development of respiratory allergies in children.
The article describes the clinical manifestation and course of pollen bronchial asthma in children. One of the most severe clinical manifestations of pollinosis is seasonal pollen asthma. Her attacks usually begin suddenly and acutely. In some cases, an asthma attack develops against the background of aggravated allergic rhinitis and conjunctivitis. It was determined that almost all patients had symptoms that began with the appearance of sneezing and itching in the nose and coughing, difficulty breathing, and attacks of suffocation. Pollen bronchial asthma in children is characterized by a cyclical course.
Allergic rhinitis is a disease that is based on IgE-mediated inflammation of the nasal mucosa (caused by allergens), characterized by at least two of the following symptoms daily: nasal congestion, nasal discharge (rhinorrhea), sneezing, itching in the nasal cavity. Allergic rhinitis is often combined with other allergic diseases, such as bronchial asthma, allergic conjunctivitis, atopic dermatitis, and certainly is a global medical and social problem. Although allergic rhinitis is a serious, lifethreatening disease, nevertheless, its medical and social significance is due to its high prevalence among children, adolescents and adults, especially in combination with acute and chronic sinusitis, otitis media and bronchial asthma
Актуальность темы: Противовоспалительная терапия является основой лечения пациентов с воспалительными заболеваниями глаз. Хотя глюкокортикостероиды (ГКС) демонстрируют мощный противовоспалительный и противоаллергический эффект, лечение ГКС связано с риском серьезных побочных эффектов. Нестероидные противовоспалительные агенты (НПВП) обладают несколько более низкой противовоспалительной активностью по сравнению с ГКС, и их разработка и внедрение в клиническую офтальмологическую практику кажутся разумными. Цель: оценить эффективность 0,5% бензкетозоновой мази, нового местного глазного препарата, производимого в Узбекистане, при лечении инфекционного конъюнктивита и блефарита. Материалы и методы. В исследование был включен 131 пациент (175 глаз; 64 мужчины и 67 женщин) для оценки эффективности лечения воспалительных заболеваний глаз 0,5% бензкетозоновой мазью (Свидетельство №06-07). Пациенты контрольной группы получали традиционную терапию, в то время как пациенты опытной группы получали 0,5% бензкетозоновую мазь в дополнение к традиционной терапии. Для контроля терапевтического эффекта использовалась модифицированная методика импрессивной цитологии. Результаты: модифицированная импрессионная цитология показала, что включение бензкетозоновой мази в традиционное лечение конъюнктивита или блефарита привело к значительному снижению экссудации и пролиферации клеток, что проявлялось в уменьшении количества базофилов и эозинофилов, восстановлении структуры эпителиальных клеток и более ранняя нормализация средних значений нуклеоцитоплазматического соотношения и более раннее снижение тканевого и белкового детрита в конъюнктивальных образцах опытной группы по сравнению с контролем. Заключение. Модифицированная импрессионная цитология показала, что включение бензкетозоновой мази в традиционное лечение конъюнктивита или блефарита улучшило регенеративную активность, метаболические процессы и симптомы глазного воспаления.
The features of the clinic and treatment of patients with adenoviral keratoconjunctivitis were studied on the example of 112 patients aged 19- 57 years
Intrauterine infections are caused mainly by bacterial and viral pathogens that have penetrated to the fetus from the mother before or during childbirth. Intrauterine infection (IUI) has numerous manifestations, such as conjunctivitis, rhinitis, pyoderma, pneumonia, hepatitis, otitis, meningoencephalitis, up to the development of sepsis. However, intrauterine infection does not always lead to generalized IUI, in some cases infected children do not have any clinical symptoms of the disease. The aim of the study was to study the most common variants of IUI in newborns and to determine their relationship with infectious urogenital and extragenital diseases of the mother. The analysis of the birth histories and the development histories of newborns, including the somatic and obstetric-gynecological anamnesis of the pregnant woman, the course of pregnancy and childbirth, the results of clinical and laboratory studies, as well as the assessment of the child's condition after childbirth, was carried out.